The biological effect of 125I seed continuous low dose rate irradiation in CL187 cells

Abstract

Background: To investigate the effectiveness and mechanism of 125 I seed continuous low-doserate irradiation on colonic cell line CL187 in vitro.

Iodine-125 irradiation inhibits invasion of gastric cancer cells by reactivating microRNA-181c expression

“…Several studies have indicated that 125 I seed irradiation is effective in inducing cell apoptosis in pancreatic and colonic cancer cells (4,11,32 Previous studies have revealed that altered DNA methylation patterns may be critical in tumor inhibition resulting from consecutive low-energy 125 I irradiation (11). Ma et al (11) demonstrated that low-dose (4 Gy) 125 I irradiation causes a significant decrease in DNMT expression in pancreatic cancer cells.…”

“…Iodine-125 ( 125 I) seeds have a long half-life and low energy with excellent stability, which has resulted in their extensive clinical use (4). Brachytherapy with low-dose 125 I seeds has been demonstrated to be an effective salvage therapy for gastric cancer and other malignant carcinomas (5)(6)(7)(8)(9)(10).…”

Continuous low-dose irradiation by I-125 seeds induces apoptosis of gastric cancer cells regardless of histological origin

“…However, this remains controversial 18,23 and, moreover, this was reported in only one histological type of gastric cancer or cancer of other organs [24][25][26][27] Undifferentiated cancer cells are generally more sensitive to radiation. Thus, radiation effects may vary with cancer histology.…”

“…In recent years, I-125 seed implantation providing continuous low-dose-rate irradiation has been widely used to treat prostate cancer and other kinds of tumors in several Asian countries because of little trauma, strong effect, and fewer complications, [18][19][20][21] The efficacy of conventional radiation therapy for gastric cancer is controversial. In this study, we evaluated the in vitro and in vivo effects of continuous low-dose-rate irradiation by I-125 seeds on different histological types of gastric cancer cell lines.…”

Differential Gene Expression Profiles of Radioresistant Non–Small-Cell Lung Cancer Cell Lines Established by Fractionated Irradiation: Tumor Protein p53-Inducible Protein 3 Confers Sensitivity to Ionizing Radiation

“…Apoptosis after G2/M cell cycle arrest is either the main or a very important mechanism of the cell-killing effects of irradiation (21)(22)(23). Newly established radioresistant H460R cells showed decreased G2/M arrest in response to irradiation compared with parental H460R cells (Fig.…”