The Biological Functions and Clinical Applications of Integrins in Cancers

Su, Chaoyue; Li, Jingquan; Zhang, Lingling; Wang, Hui; Wang, Fenghua; Tao, Yiwen; Wang, Yuqing; Guo, Qiaoru; Li, Jiajun; Liu, Yun; Yan, Yanyan; Zhang, Jianye

doi:10.3389/fphar.2020.579068

Cited by 86 publications

(107 citation statements)

References 119 publications

Supporting

Mentioning

104

Contrasting

Unclassified

Order By: Relevance

“…Given the wide clinical use of vinca alkaloids and taxanes, currently, the microtubules represent the best target to date for cancer chemotherapy 69 . However, several clinical trials have proved integrins to be a promising therapeutic target to battle cancer cells, though no specific drug was found to be exceptionally effective 71 . We believe the experimental techniques used in our study and the results provided by them to be of aid to develop novel integrin targeting drugs.…”

Section: Discussionmentioning

confidence: 99%

Single-cell adhesion strength and contact density drops in the M phase of cancer cells

Ungai-Salánki

Haty

Gerecsei

et al. 2021

Sci Rep

View full text Add to dashboard Cite

The high throughput, cost effective and sensitive quantification of cell adhesion strength at the single-cell level is still a challenging task. The adhesion force between tissue cells and their environment is crucial in all multicellular organisms. Integrins transmit force between the intracellular cytoskeleton and the extracellular matrix. This force is not only a mechanical interaction but a way of signal transduction as well. For instance, adhesion-dependent cells switch to an apoptotic mode in the lack of adhesion forces. Adhesion of tumor cells is a potential therapeutic target, as it is actively modulated during tissue invasion and cell release to the bloodstream resulting in metastasis. We investigated the integrin-mediated adhesion between cancer cells and their RGD (Arg-Gly-Asp) motif displaying biomimetic substratum using the HeLa cell line transfected by the Fucci fluorescent cell cycle reporter construct. We employed a computer-controlled micropipette and a high spatial resolution label-free resonant waveguide grating-based optical sensor calibrated to adhesion force and energy at the single-cell level. We found that the overall adhesion strength of single cancer cells is approximately constant in all phases except the mitotic (M) phase with a significantly lower adhesion. Single-cell evanescent field based biosensor measurements revealed that at the mitotic phase the cell material mass per unit area inside the cell-substratum contact zone is significantly less, too. Importantly, the weaker mitotic adhesion is not simply a direct consequence of the measured smaller contact area. Our results highlight these differences in the mitotic reticular adhesions and confirm that cell adhesion is a promising target of selective cancer drugs as the vast majority of normal, differentiated tissue cells do not enter the M phase and do not divide.

show abstract

Section: Discussionmentioning

confidence: 99%

Single-cell adhesion strength and contact density drops in the M phase of cancer cells

Ungai-Salánki

Haty

Gerecsei

et al. 2021

Sci Rep

View full text Add to dashboard Cite

show abstract

“… 190 Exosomal tenascin C interacted with integrin α5β1 and αvβ6 on T cells, subsequently attenuated the expression of p-mTOR signaling. 190 , 191 It was worth noting that another study reported that GSCs-derived exosomes did not directly interact with T cells to suppress T cell immune responses, but induced monocytic myeloid-derived suppressor cells and inhibited the maturation of monocytes. 192 When CD14 + monocytes were removed from PBMC, the inhibitory effect of GSCs-exosomes on T cell proliferation could be partially rescued.…”

Section: The Biological Roles Of Cscs-derived Evsmentioning

confidence: 99%

The key roles of cancer stem cell-derived extracellular vesicles

Zhang

Yarden

et al. 2021

Sig Transduct Target Ther

View full text Add to dashboard Cite

Cancer stem cells (CSCs), the subpopulation of cancer cells, have the capability of proliferation, self-renewal, and differentiation. The presence of CSCs is a key factor leading to tumor progression and metastasis. Extracellular vesicles (EVs) are nano-sized particles released by different kinds of cells and have the capacity to deliver certain cargoes, such as nucleic acids, proteins, and lipids, which have been recognized as a vital mediator in cell-to-cell communication. Recently, more and more studies have reported that EVs shed by CSCs make a significant contribution to tumor progression. CSCs-derived EVs are involved in tumor resistance, metastasis, angiogenesis, as well as the maintenance of stemness phenotype and tumor immunosuppression microenvironment. Here, we summarized the molecular mechanism by which CSCs-derived EVs in tumor progression. We believed that the fully understanding of the roles of CSCs-derived EVs in tumor development will definitely provide new ideas for CSCs-based therapeutic strategies.

show abstract

“…This is due to the fact, that the ECM of the TME can be different for certain tumor entities [ 111 ] and for different stages of tumor progression [ 30 ]. Likewise, the role of the ECM receptors is diverse and not entirely defined for each cell type within the TME at any stage of tumor progression and dissemination [ 72 , 75 , 78 , 112 ]. However, the ECM contacts of cells in the TME affect inter alia the secretion and deposition, as well as the remodeling of ECM components.…”

Section: The “Give and Take” Between The Ecm And Cells Within The mentioning

confidence: 99%

Hold on or Cut? Integrin- and MMP-Mediated Cell–Matrix Interactions in the Tumor Microenvironment

Niland

Eble

2020

IJMS

View full text Add to dashboard Cite

The tumor microenvironment (TME) has become the focus of interest in cancer research and treatment. It includes the extracellular matrix (ECM) and ECM-modifying enzymes that are secreted by cancer and neighboring cells. The ECM serves both to anchor the tumor cells embedded in it and as a means of communication between the various cellular and non-cellular components of the TME. The cells of the TME modify their surrounding cancer-characteristic ECM. This in turn provides feedback to them via cellular receptors, thereby regulating, together with cytokines and exosomes, differentiation processes as well as tumor progression and spread. Matrix remodeling is accomplished by altering the repertoire of ECM components and by biophysical changes in stiffness and tension caused by ECM-crosslinking and ECM-degrading enzymes, in particular matrix metalloproteinases (MMPs). These can degrade ECM barriers or, by partial proteolysis, release soluble ECM fragments called matrikines, which influence cells inside and outside the TME. This review examines the changes in the ECM of the TME and the interaction between cells and the ECM, with a particular focus on MMPs.

show abstract

The Biological Functions and Clinical Applications of Integrins in Cancers

Cited by 86 publications

References 119 publications

Single-cell adhesion strength and contact density drops in the M phase of cancer cells

Single-cell adhesion strength and contact density drops in the M phase of cancer cells

The key roles of cancer stem cell-derived extracellular vesicles

Hold on or Cut? Integrin- and MMP-Mediated Cell–Matrix Interactions in the Tumor Microenvironment

Contact Info

Product

Resources

About