The biological functions of europium-containing biomaterials: A systematic review

Wu, Likun; Yang, Fan; Xue, Yijia; Gu, Ranli; Líu, Hao; Xia, Dandan; Liu, Yunsong

doi:10.1016/j.mtbio.2023.100595

Cited by 20 publications

(10 citation statements)

References 109 publications

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“…In this regard, stimuli-responsive materials find useful applications in various fields such as filtration, controlled drug delivery, sensing, and affecting their interaction with water and oil. 16,30–40…”

Section: Introductionmentioning

confidence: 99%

Preparation and application of stimuli-responsive PET TeMs: RAFT graft block copolymerisation of styrene and acrylic acid for the separation of water–oil emulsions

Muslimova,

Zhumanazar,

Melnikova

et al. 2024

RSC Adv.

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Section: Introductionmentioning

confidence: 99%

Preparation and application of stimuli-responsive PET TeMs: RAFT graft block copolymerisation of styrene and acrylic acid for the separation of water–oil emulsions

Muslimova,

Zhumanazar,

Melnikova

et al. 2024

RSC Adv.

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“…[ 19 ] Eu 3+ has been reported to exhibit potent pro‐angiogenic effects on skin and bone repair by stimulating the expression of angiogenesis‐related proteins. [ 20 ] Therefore, we envision that a functionalized platform based on TA, PAs, and Eu 3+ can be built on a CS hydrogel constructed by programmed hydrogen bonding. This combination improves mitochondrial function, scavenges ROS, and promotes vascularization, ultimately promoting MI repair.…”

Section: Introductionmentioning

confidence: 99%

A Strongly Robust Chitosan‐Based Programmed Control Functional Hydrogel Improved Mitochondrial Function and Pro‐Vascularization for Adaptive Repair of Myocardial Infarction

Li,

Cao

et al. 2024

Adv Funct Materials

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Hydrogel‐based engineered cardiac patches (ECP) hold great promise as potential treatment options for myocardial infarction (MI). However, optimizing the preparation of ECP with better biocompatibility, mechanical stability, and adaptation to MI repair remains a challenge. In this study, a chitosan (CS) hydrogel with good mechanical robustness through programmed control of hydrogen bonding is constructed to adapt to the continuous beating of myocardial tissue. With the synergistic effects of lipoic acid (TA), proanthocyanidins (PAs), and Eu3+, a functional platform capable of improving mitochondrial function, antioxidation, and pro‐vascularization is further constructed for the adaptive repair of the MI microenvironment. The fabricated functionalized chitosan hydrogel (CS/TA@PAs‐Eu) possessed good mechanical stability and ionic conductivity, showing the potential for long‐term adaptation to myocardial tissue pulsation. Also, the CS/TA@PAs‐Eu hydrogel promoted cardiomyocytes (CMs) maturation and functionalization, and effectively improved mitochondrial function, scavenged reactive oxygen species (ROS) as well as promoted angiogenesis. Animal studies indicated that the CS/TA@PAs‐Eu hydrogel can perform adaptive repair of MI to prevent left ventricular (LV) remodeling and restore cardiac function. This study highlights a functionalized hydrogel ECP with good biocompatibility and mechanical robustness for the adaptive repair of MI.

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“…9,10,18 The presence of both valence states (+2 and +3) may have an impact on the well-known bone resorption process during bone remodeling. 22 Bone remodeling is executed by osteoclasts that resorb bone and osteoblasts that fill the resorption cavities with a bone matrix that subsequently becomes mineralized through a process of bone mineralization. The stimulation of osteoblasts in the process of bone mineralization is related to the ability of HAp to release phosphorus and calcium ions from their structure.…”

Section: Introductionmentioning

confidence: 99%

“…Most of the rare-earth ions employed when doping HAp possess a valence state of +3 . However, in previous work, we have reported the presence of Eu 2+ and Yb 2+ in calcium-deficient HAp. ,, The presence of both valence states (+2 and +3) may have an impact on the well-known bone resorption process during bone remodeling . Bone remodeling is executed by osteoclasts that resorb bone and osteoblasts that fill the resorption cavities with a bone matrix that subsequently becomes mineralized through a process of bone mineralization.…”

Section: Introductionmentioning

confidence: 99%

Decomposition of Luminescent Hydroxyapatite Scaffolds in Simulated Body Fluid

Martinez-Pallares,

Herrera,

Graeve

2024

ACS Appl. Bio Mater.

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We present a luminescence study investigating the dissolution of rare-earth-doped hydroxyapatite scaffolds in simulated body fluid (SBF), aiming to assess the luminescence stability of Tb-, Ce-, and Eu-doped scaffolds over time. Our findings reveal a consistent decrease in luminescence emission intensity across all samples over a four-week period in which the scaffolds were immersed in the SBF. In addition, energy-dispersive spectroscopy confirms a decrease in rare-earth ion concentration in the scaffolds with respect to time, whereas fluorescence spectroscopy shows the presence of rare-earth ions in the SBF, indicating the partial dissolution of the scaffolds over time. The use of rareearth ions as luminescence markers provides insights into the mechanisms of apatite formation in hydroxyapatites. Thus, these scaffolds may find wider use in regenerative medicine, particularly in targeted drug delivery systems, where their luminescent properties have the potential to noninvasively track drug release.

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The biological functions of europium-containing biomaterials: A systematic review

Cited by 20 publications

References 109 publications

Preparation and application of stimuli-responsive PET TeMs: RAFT graft block copolymerisation of styrene and acrylic acid for the separation of water–oil emulsions

Preparation and application of stimuli-responsive PET TeMs: RAFT graft block copolymerisation of styrene and acrylic acid for the separation of water–oil emulsions

A Strongly Robust Chitosan‐Based Programmed Control Functional Hydrogel Improved Mitochondrial Function and Pro‐Vascularization for Adaptive Repair of Myocardial Infarction

Decomposition of Luminescent Hydroxyapatite Scaffolds in Simulated Body Fluid

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