The biology of HIV-associated lymphomas

Bower, Mark

doi:10.1038/bjc.1992.289

Cited by 6 publications

(1 citation statement)

References 27 publications

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“…Augmented levels of IL-6 and IL-10 have been reported in EBER + BL lines when compared to EBER - BL lines by Brady et al [ 21 ]. Bower [ 22 ], reported that simultaneous infection enhanced growth of EBV transformed lymphoblastoid cell lines in vitro. This implies that cytokines in response to prevailing may participate in the development of BL in-vivo.…”

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confidence: 99%

Cytokines associated with Burkitt’s lymphoma in western Kenya

et al. 2017

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ObjectiveBurkitt’s lymphoma (BL) is a common aggressive non-Hodgkin’s lymphoma in East and Central Africa among children. Persistent infections with Epstein Barr virus or Plasmodium falciparum are associated with immune hyperstimulation. It is hypothesised that inadvertent cytokine responses to infections indirectly or directly influence B cell neoplastic transformation through c-myelocytomatosis (c-myc) gene translocation. We sought to describe cytokines in children and adolescents with BL. Participants were recruited from western Kenya with parental consent, diagnosis confirmed using histology and consensus panel of immunohistochemistry antibodies. T helper1/2/17A and transforming growth factor-β1 (TGF-β1) cytokines were estimated using cytometric bead array in plasma. Complete blood counts (CBC) were determined by Beckman Coulter®.ResultsOut of 104 enrolled participants, 32% were confirmed BL and 68% grouped as non-BL. Mean (pg/ml) levels of cytokines in BL and non-BL were: interleukin (IL)-6 100.3 and 39.4 p = 0.152; IL-10 11.5 and 12.5 p = 0.363; IL-17A 17.8 and 64.9 p = 0.094 respectively. Expressions of interferon-γ, IL-2 and tumour necrosis factor-α were low and TGF-β1 undetectable in both groups. Mean CBC differed between the two groups before and after chemotherapy, WBC being significantly so. Interleukin-6, IL-17A and IL-10 responses to infections in the study area may be associated with pathogenesis and be potential therapeutic targets.

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confidence: 99%