The biology of human hair: A multidisciplinary review

Koch, Sandra; Tridico, Silvana R.; Bernard, Bruno; Shriver, Mark D.; Jablonski, Nina G.

doi:10.1002/ajhb.23316

Cited by 38 publications

(24 citation statements)

References 139 publications

(220 reference statements)

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“…• кутикула волоса -оточує кіркову речовину і складається з клітин, які перетворюються на рогові лусочки і розташовуються у вигляді черепиці [3,4].…”

Section: анатомія і розвиток волосяних фолікулів і сальних залозunclassified

Androgen-associated and androgen-independent causes of alopecia and acne in women. Literature review

Сидорова

Тутченко

Бурка

et al. 2020

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This article refers to the issues of alopecia and acne pathogenesis: anatomy of hair and sebaceous glands, biological factors affecting the stages of hair development and function of sebaceous glands. Alopecia is divided into two large groups: scaring and non-scaring alopecia, the later is represented by alopecia areata, telogen effluvium, and female pattern hair loss/androgenetic alopecia (FPHL/AGA). Before starting the search for systemic causes it is necessary to predetermine the type of alopecia on the basis of medical history and external manifestations. FPHL /AGA as a most common form of alopecia can often coexist with another common pathology – telogen effluvium, this fact determines therapeutic approaches and their results.Main pathogenetic mechanisms, approaches to differential diagnostics and treatment of the main specified types of non-scarring alopecia are reviewed. FPHL/AGA is a main type of alopecia which is often referred to gynecologists/endocrinologists. It is now regarded a multifactorial pathology with the involvement of a genetic component, androgen receptor gene expression, dihydrotestosterone synthesis and local low grade inflammation specifics. FPHL/AGA can be with and without hyperandrogenism, in both cases it can be accompanied by an increased risk of metabolic syndrome. In case of FPHL/AGA with hyperandrogenism the success of treatment depends on the consistent coordinated work of gynecologist/endocrinologist and dermatologist/trichologist, which allows combining systemic and local therapy in a timely manner.Also contemporary views on the acne pathogenesis are reviewed. Given the complex nature of acne its therapy is also complex and stepwise. According to current clinical guidelines and recent studies of the microbial component of acne pathogenesis the following conclusions are formulated. Patients with acne require assessment of androgen status, determination of the hyperandrogenism source, including evaluation of tissue androgens; phenotype of the syndrome and cardio-metabolic risks should be determined in patients with polycystic ovary syndrome; it is advisable to determine antimicrobial susceptibility of pathogens isolated from the inflamed pilosebaceous unit if acne form requires the local or systemic antibacterial therapy.

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Section: анатомія і розвиток волосяних фолікулів і сальних залозunclassified

Androgen-associated and androgen-independent causes of alopecia and acne in women. Literature review

Сидорова

Тутченко

Бурка

et al. 2020

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“…Hair morphology can be examined at multiple scales, from characterization of the cortical cells, medulla, and cuticle to descriptions of overall macroscopic “texture” perceived when considering a head of hair in its entirety. Variations in hair morphology have been linked to variation in DNA sequence, as well as in cellular, protein, and chemical structure 1 . However, focus on investigating the underlying causes of the perceived macroscopic variation has come at the expense of developing language and methodology for describing the phenotype itself.…”

Section: Introductionmentioning

confidence: 99%

High-throughput phenotyping methods for quantifying hair fiber morphology

Lasisi

Zaidi

Webster

et al. 2020

Preprint

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Quantifying the continuous variation in human scalp hair morphology is of interest to anthropologists, geneticists, dermatologists and forensic scientists, but existing methods for studying hair form are time-consuming and not widely used. Here, we present a high-throughput sample preparation protocol for the imaging of both longitudinal (curvature) and cross-sectional scalp hair morphology. Additionally, we describe and validate a new Python package designed to process longitudinal and cross-sectional hair images, segment them, and provide measurements of interest. Lastly, we apply our methods to an admixed African-European sample (n=140), demonstrating the benefit of quantifying hair morphology over qualitative classification or racial categories, and providing evidence against the long-held belief that cross-sectional morphology predicts curvature.

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“…The pigment granules can be ~100–800 nm in size [11,14]. In addition to pigment granules, cortical fusi are irregularly shaped air pockets, and ovoid bodies are dark structures that may also be found in the hair's cortex [10,15]. The spacing and distribution of the pigment granules, cortical fusi, and ovoid bodies can be used to describe the hair's cortical texture.…”

Section: Introductionmentioning

confidence: 99%

“…Similarly, color is usually described by general color categories (e.g., red, blond, brown, and black) [15,16]. Variations in hair color and texture are dependent on the melanosome size, type, and shape, which can differ by ancestry [10].…”

Section: Introductionmentioning

confidence: 99%

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Analysis of hair color and texture for forensic examinations

Funes

Bridge

2020

Journal of Forensic Sciences

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Efforts have been conducted to evaluate hair features empirically, for example, color; however, a review of current literature showed few studies investigating cortical texture analysis. The development of high‐resolution digital microscopes allows researchers to obtain more accurate measurements of hair features. In this study, digital microscopy was used to explore variance within the cortical texture, color, and density characteristics throughout hair strands. In this study, 20–25 naturally shed hairs from 12 individuals of different ancestries were collected. Measurements of three different features were collected: entropy texture measurements, that is, measurement of the randomness of pigment granules and cortical fusi; color distributions of the hairs via a red–green–blue (RGB) color model; and the calculation of the pigment density ratio using hue–saturation–value color model. Analysis of variance was performed on data collected from each analysis type to assess inter‐ and intra‐person variability. The F‐ratios obtained, which compares inter‐person to intra‐person variability, ranged from 9.29 to 69.24. Cortical texture and color measurements showed promising results in differentiating between inter‐person samples. Although density ratios showed the least potential for discrimination, it provided another level for differentiating inter‐person hair samples. The location that provided the best differentiation of strands from different donors could be made at a 20.0 mm distance from the strand's proximal end for all three features measured. The methods proposed in this study show the potential to quantify hair features that exhibit better differentiation of hair from different individuals.

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The biology of human hair: A multidisciplinary review

Cited by 38 publications

References 139 publications

Androgen-associated and androgen-independent causes of alopecia and acne in women. Literature review

Androgen-associated and androgen-independent causes of alopecia and acne in women. Literature review

High-throughput phenotyping methods for quantifying hair fiber morphology

Analysis of hair color and texture for forensic examinations

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