The biology of malaria transmission

Sinden, Robert E.

doi:10.1002/9781118493816.ch4

Cited by 4 publications

(3 citation statements)

References 211 publications

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“…The molecular and genetic bases of mosquito competence for malaria parasites have been well characterized for a number of mosquito–parasite associations (Aly, Vaughan, & Kappe, ; Beier, ; Bennink, Kiesow, & Pradel, ; Cirimotich, Dong, Garver, Sim, & Dimopoulos, ; Li et al., ; Molina‐Cruz et al., ; Redmond et al., ; Severo & Levashina, ; Sinden, ; Sinden, Alavi, & Raine, ). For example, different strains or families of Anopheles gambiae , the primary vector of malaria in Africa, display a wide range of susceptibility for a given parasite genotype (Blandin et al, ; Harris et al, ) and different Plasmodium isolates also vary in their infectivity to a given mosquito strain (Molina‐Cruz et al., ).…”

Section: Mosquito Competence (V)mentioning

confidence: 99%

“…An important assumption of this hypothesis is that there must be a positive relationship between sporozoite burden in the salivary glands and infection of the vertebrate host, something that has long been disputed (Beier, Davis, Vaughan, Noden, & Beier, ; Beier et al., ; Ponnudurai, Lensen, Vangemert, Bolmer, & Meuwissen, ; Sinden, ). A recent study using rodent parasites provides strong support for this relationship by showing that mosquitoes with higher numbers of sporozoites in salivary glands are indeed more likely to transmit malaria (Churcher et al., ).…”

Section: Mosquito Competence (V)mentioning

confidence: 99%

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Transmission traits of malaria parasites within the mosquito: Genetic variation, phenotypic plasticity, and consequences for control

Lefèvre

Ohm

Dabiré

et al. 2017

Evolutionary Applications

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Evaluating the risk of emergence and transmission of vector‐borne diseases requires knowledge of the genetic and environmental contributions to pathogen transmission traits. Compared to the significant effort devoted to understanding the biology of malaria transmission from vertebrate hosts to mosquito vectors, the strategies that malaria parasites have evolved to maximize transmission from vectors to vertebrate hosts have been largely overlooked. While determinants of infection success within the mosquito host have recently received attention, the causes of variability for other key transmission traits of malaria, namely the duration of parasite development and its virulence within the vector, as well as its ability to alter mosquito behavior, remain largely unknown. This important gap in our knowledge needs to be bridged in order to obtain an integrative view of the ecology and evolution of malaria transmission strategies. Associations between transmission traits also need to be characterized, as they trade‐offs and constraints could have important implications for understanding the evolution of parasite transmission. Finally, theoretical studies are required to evaluate how genetic and environmental influences on parasite transmission traits can shape malaria dynamics and evolution in response to disease control.

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Section: Mosquito Competence (V)mentioning

confidence: 99%

Section: Mosquito Competence (V)mentioning

confidence: 99%

Transmission traits of malaria parasites within the mosquito: Genetic variation, phenotypic plasticity, and consequences for control

Lefèvre

Ohm

Dabiré

et al. 2017

Evolutionary Applications

View full text Add to dashboard Cite

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“…Additionally, some parasites take an alternative route, developing into gametocytes, a crucial stage for mosquito transmission. Understanding the molecular details of this process is fundamental to devising strategies for malaria control and elimination [6].…”

Section: Introductionmentioning

confidence: 99%

Plasmodial Transcription Factors and Chromatin Modifiers as Drug Targets

Sepulveda,

de Oliveira,

Chagas

et al. 2023

Future Pharmacology

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The complex life cycle of the malaria parasite Plasmodium requires the parasite to adequately adapt to different conditions. For this reason, Plasmodium strictly controls its gene expression, and given its evolutionary distance from the human host, the involved factors may figure as attractive potential drug targets. In recent years, several unique transcription factors and chromatin modifiers have been identified and partially characterized in Plasmodium falciparum and in the murine species P. yoelii and P. berghei. This review unites data from studies focusing on drug development against enigmatic plant-like AP2-transcription factors and chromatin modifiers, such as histone acetyl transferases and deacetylases and histone methyltransferases and demethylases. Considering the reported success of inhibition of both factors, these may be included as targets to effectively combat the parasite by perturbing its control of gene expression.

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