2018
DOI: 10.1016/j.immuni.2018.12.001
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The Biology of T Regulatory Type 1 Cells and Their Therapeutic Application in Immune-Mediated Diseases

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Cited by 271 publications
(277 citation statements)
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“…Besides its role in regulating cytotoxic activity of CD4 + T-cells, the importance of EOMES in the generation of T R 1 T-cells was recently shown (7, 8). T R 1 T-cells do not constitutively express FOXP3, produce the immunosuppressive cytokine IL-10, express co-inhibitory receptors such as PD-1, and are able to suppress the function of effector immune cells (10). The expression of IL-10 and other cytokines and their receptors, in combination with increased expression levels of inhibitory receptors are shared features of CD4 + EOMES + T-cells in B-NHL and T R 1 cells.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Besides its role in regulating cytotoxic activity of CD4 + T-cells, the importance of EOMES in the generation of T R 1 T-cells was recently shown (7, 8). T R 1 T-cells do not constitutively express FOXP3, produce the immunosuppressive cytokine IL-10, express co-inhibitory receptors such as PD-1, and are able to suppress the function of effector immune cells (10). The expression of IL-10 and other cytokines and their receptors, in combination with increased expression levels of inhibitory receptors are shared features of CD4 + EOMES + T-cells in B-NHL and T R 1 cells.…”
Section: Discussionmentioning
confidence: 99%
“…Despite abundant data characterizing CD4 + T-cells and their subsets in B-cell Non-Hodgkin lymphoma (B-NHL) (1), and in particularly chronic lymphocytic leukemia (CLL) (2-6), their role in disease development and progression is poorly understood. Besides well-known T helper (Th) cell subsets (5), interleukin (IL-)10 producing, FOXP3 - conventional CD4 + T-cells, named type 1 regulatory (T R 1) cells, are gaining attention in mouse models as well as patients harboring chronic inflammatory conditions such as inflammatory bowel disease (7-10). T R 1 cells were initially described as IL-10-induced cells that produce IL-10 and IFNγ and harbor cytotoxic activity, but also express several co-inhibitory receptors such as programmed cell death protein-1 (PD-1).…”
Section: Introductionmentioning
confidence: 99%
“…Co-expression analysis of the expression levels of immune cells obtained in this study showed that the correlation between T cells regulatory (Tregs) [10][11][12][13]and Neutrophils [14][15][16][17] was the strongest, with a coe cient of 0.78, and the two cells with the weakest correlation were Macrophages [18][19] and T cells follicular helper [20][21], the correlation coe cient is -0.59 (Figure 3). After obtaining the matrix of immune cells, we wondered whether these immune cells could distinguish between the normal group and the tumor group.…”
Section: Co-expression Analysis Between Immune Cellsmentioning
confidence: 77%
“…This transcriptomic signature seems to be disease-specific, although similarities with other pathogenic CD4 T cells involved in several autoimmune disorders were observed. Indeed, in autoimmune disorders, distinct pathogenic CD4 T cell molecular signatures have been reported, including a TFH and TPH signature 5,6,9,18,22,24,25 , a TH10 and Tr1/Treg 23,48,49 (regulatory T cell) signature, and a TH17-like signature 16,19,20,38,50 . Here, we have shown that SLA-specific CD4 T cells had a transcriptomic signature close to the TPH signature 22,24,25 (IFNG, IL21, MAF, CD200, ICOS, CTLA4, ITM2A, TIGIT and SLAMF6).…”
Section: Discussionmentioning
confidence: 99%