The Biology of Vascular Endothelial Growth Factor

Interleukin-6 promotes cervical tumor growth by VEGF-dependent angiogenesis via a STAT3 pathway

“…Supporting evidences were obtained from previous works on head and neck cancer, multiple myeloma, basal cell carcinoma, and Kaposi's sarcoma (Aoki et al, 1999;Dankbar et al, 2000;Jee et al, 2001). VEGF is a potent angiogenic factor that is pivotal in the transition from an avascular tumor to a vascularizing phenotype tumor (Ferrara and Davis-Smyth, 1997). VEGF expression has been reported to be associated with the progression of cervical intraepithelial neoplasia (Guidi et al, 1995;Dobbs et al, 1997), the angiogenesis and early invasion of cervical cancer, and the prognosis of patients with early-stage cervical cancer (Kodama et al, 1999;Cheng et al, 2000).…”

Molecular basis of angiogenesis and cancer

“…In addition, VEGF expression is induced by growth factors and cytokines such as PDGF, EGF, TNF-a, TGF-b1, and IL-1 (Ferrara and Davis-Smyth, 1997;Neufeld et al, 1999).…”

Mechanisms of angiogenesis and their use in the inhibition of tumor growth and metastasis

“…Inhibition of VEGF signaling either by dominant-negative VEGFR-2, soluble forms of the VEGFR-1 or anti-VEGF antibody decreases tumor growth in experimental models (Millauer et al, 1994;Kong et al, 1998;Kim et al, 1993). VEGF mRNA is known to be upregulated in most human tumors and expression of VEGF and its receptors correlates with the degree of vascularization of many experimental and clinical tumors (Ferrara and Davis-Smyth, 1997). Loss of VEGF expression also can lead to tumor regression Benjamin and Keshet, 1997).…”