The BIOSAFEPAPER project for in vitro toxicity assessments: Preparation, detailed chemical characterisation and testing of extracts from paper and board samples

Bradley, Emma; Honkalampi-Hämäläinen, Ulla; Weber, Assi; Andersson, Maria A.; Bertaud, Frédérique; Castle, Laurence; Dahlman, Olof; Hakulinen, Pasi; Hoornstra, Douwe; Lhuguenot, Jean-Claude; Mäki‐Paakkanen, Jorma; Salkinoja‐Salonen, Mirja; Speck, D.R.; Séverin, Isabelle; Stammati, Annalaura; Turco, Laura; Zucco, Flavia; Wright, Atte von

doi:10.1016/j.fct.2008.04.017

Cited by 51 publications

(32 citation statements)

References 21 publications

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“…Therefore, some interdisciplinary studies have tried to screen paper and board FCMs by using both chemical analysis and in vitro tests (Vinggaard et al 2000;Binderup et al 2002;Lopez-Espinosa et al 2007;Bradley et al 2008;Koster et al 2014). This process is used as a fast screening, excluding irrelevant samples and enabling further investigations on only toxicologically relevant samples.…”

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confidence: 99%

“…This approach leads to high demands on the extraction method, as it should be both comprehensive and compatible with in vitro assays. Even after an initial screening phase, the analysis of toxicologically relevant extracts by chromatographic methods will still give complex results, described as a forest-of-peaks analysis (Bradley et al 2008Koster et al 2014). By fractioning the raw extracts into a number of fractions, and subsequently testing these in in vitro assays, the number of substances relevant for identification will be further reduced.…”

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confidence: 99%

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Fractionation of extracts from paper and board food contact materials forin vitroscreening of toxicity

Bengtström

Trier

Granby

et al. 2014

Food Additives & Contaminants: Part A

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Paper and board used as food contact materials (FCMs) are chemically complex matrices, partly due to the naturally occurring substances in paper and board, but also due to the chemical treatment of the paper used to make it suitable for food contact. In order to assure the safety of packaging materials, information on the exposure as well as on the toxicity of substances in the packaging must be obtained. This study describes a comprehensive method for the extraction and fractionation of substances present in paper and board FCMs for further investigation by in vitro testing and chemical analysis. The extraction efficiency and the fractionation process were validated by determining recoveries in extracts from paper and board fortified with five surrogates of known concentration. The recoveries for the five surrogates were between 20% and 104% in the raw extract and between 21% and 109% after extraction and fractionation. The fractionation both reduces the number of compounds to be identified and works as a sample clean-up by reducing matrix effects. Raw extracts and fractions from two paper and board FCMs were furthermore tested in the aryl hydrocarbon receptor (AhR) reporter gene assay. Both raw extracts and two of the fractions of the raw extracts gave a positive response in the AhR assay. The strategy of extraction followed by fractionation offers a powerful tool in order to make the workflow for screening FCMs for potentially adverse effects more efficient.

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confidence: 99%

Section: Please Scroll Down For Articlementioning

confidence: 99%

Fractionation of extracts from paper and board food contact materials forin vitroscreening of toxicity

Bengtström

Trier

Granby

et al. 2014

Food Additives & Contaminants: Part A

View full text Add to dashboard Cite

show abstract

“…-Derivatisation of non-volatile substances to make these substances amenable (more volatile) to analysis by GC-MS (for example Koek et al (2006) and Bradley et al (2008));…”

Section: Complex Mixture Safety Assessment Strategy (Comsas )mentioning

confidence: 99%

A novel safety assessment strategy applied to non-selective extracts

Koster¹,

Leeman²,

Verheij³

et al. 2015

Food and Chemical Toxicology

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“…Only recently whole packaging migrates from different FCMs have been studied for their overall toxicity [15,16,47,[52][53][54]. It is noteworthy that in all studies effects of the whole leacheate were observed that could not be explained only by the known toxicity of identified or putative mixture components.…”

Section: New Toxicological Paradigms Of Relevance For Fcm Effect Assementioning

confidence: 99%

Endocrine disrupting chemicals and other substances of concern in food contact materials: An updated review of exposure, effect and risk assessment

Muncke

2011

The Journal of Steroid Biochemistry and Molecular Biology

199

114

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The BIOSAFEPAPER project for in vitro toxicity assessments: Preparation, detailed chemical characterisation and testing of extracts from paper and board samples

Cited by 51 publications

References 21 publications

Fractionation of extracts from paper and board food contact materials forin vitroscreening of toxicity

Fractionation of extracts from paper and board food contact materials forin vitroscreening of toxicity

A novel safety assessment strategy applied to non-selective extracts

Endocrine disrupting chemicals and other substances of concern in food contact materials: An updated review of exposure, effect and risk assessment

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