“…After removing duplicates and irrelevant articles, 412 full-text articles were assessed for eligibility. Fifty articles were considered eligible for the final synthesis of evidence in a systematic review and meta-analysis, 3 , 4 , 5 , 6 , 7 , 8 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 representing a total of 435,768 patients with PE, of whom 288,258 presented with isolated PE. Systematic DNA analysis was performed in 13 studies.…”