The bite-raised condition in aged SAMP8 mice induces dendritic spine changes in the hippocampal region

Kubo, Kin‐ya; Kojo, Akiko; Yamamoto, Toshiharu; Onozuka, Minoru

doi:10.1016/j.neulet.2008.05.027

Cited by 20 publications

(18 citation statements)

References 23 publications

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“…The bite-raised condition in aged SAMP8 mice decreases Fos induction following a learning task 50) , and decreases the number of spines in the hippocampus 53) . Occlusal disharmony also affects catecholaminergic activities.…”

Section: Effects Of Occlusal Disharmony On Cognitive Functionmentioning

confidence: 94%

“…In SAMP8 mice, raising the bite by approximately 0.1 mm using dental materials (bite-raised condition) induces age-dependent deficits in spatial learning in the Morris water maze [46][47][48][49][50][51][52][53] . Especially in aged SAMP8 mice, the bite-raised condition decreases neuron number 48) and increases hypertrophy and hyperplasia of glial fibrillary acid protein-labeled astrocytes 52) in the hippocampal CA3 region, suggesting that the bite-raised condition accelerates the hippocampal aging process.…”

Section: Effects Of Occlusal Disharmony On Cognitive Functionmentioning

confidence: 99%

“…In rodents and monkeys, application of dental materials to the upper molars [46][47][48][49][50][51][52][53] , attaching acrylic caps to the incisors [54][55][56] , or inserting occlusal splints in the maxilla 57,58) to raise the bite increases urinary cortisol excretion rates and plasma corticosterone levels by inducing acute and chronic stress. In monkey, the increased urinary cortisol levels induced by occlusal splints return to basal values when the splints are removed 58) .…”

Section: Effects Of Occlusal Disharmony On Cognitive Functionmentioning

confidence: 99%

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Masticatory function and cognitive function

Kubo

Ichihashi²,

Kurata³

et al. 2010

Okajimas Folia Anat. Jpn.

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Section: Effects Of Occlusal Disharmony On Cognitive Functionmentioning

confidence: 94%

Section: Effects Of Occlusal Disharmony On Cognitive Functionmentioning

confidence: 99%

Section: Effects Of Occlusal Disharmony On Cognitive Functionmentioning

confidence: 99%

See 1 more Smart Citation

Masticatory function and cognitive function

Kubo

Ichihashi²,

Kurata³

et al. 2010

Okajimas Folia Anat. Jpn.

Self Cite

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“…Previous studies have shown that occlusal disharmony induces chronic stress, which results in learning deficits in association with the morphologic changes in the hippocampus, for example, neuronal degeneration and increased hypertrophied GFAP–positive cells . Moreover, the aged bite‐raised mice showed decreased acetylcholine release in the hippocampus and a reduced number of choline acetyltransferase‐immunopositive neurons in the medial septal nucleus compared to age‐matched control mice .…”

Section: Resultsmentioning

confidence: 83%

The biological effects of occlusal trauma on the stomatognathic system – a focus on animal studies

Liu

Jiang

Wang

2012

J of Oral Rehabilitation

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The aim of this review of the literature was to assess the biological effects of occlusal trauma on the stomatognathic system focusing on animal studies. However, there are no conclusive explanations on the association between occlusal trauma and disease of the stomatognathic system. A literature survey was performed using the Medline database, covering the period from 1967 to 2012. Over 300 abstracts were reviewed, and 70 manuscripts were selected. Additional references from citations within the articles were obtained, and current textbooks were also used. This review does not include the effects of occlusal trauma on dental implants or dental prostheses/appliances. A total of 70 full articles were included for the final analysis. The selected 70 articles were classified into the following five categories, including the effects of occlusal trauma on the pulp tissues, periodontal tissues, masticatory muscle, temporomandibular joint (TMJ) and central nervous system (CNS). It was demonstrated that occlusal trauma caused a variety of harmful biological effects on stomatognathic system. Additionally, occlusal trauma could lead to some pain substance changes in the pulp, periodontal tissues, masticatory muscle, TMJ and CNS, which was possibly related to the peripheral and the central neuronal sensitisation. However, these findings demonstrate that there are remaining disagreements by various authors. More randomised trials are needed to validate these effects.

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“…In addition, impairment of special memory formation has been identified in senescenceaccelerated mice [13,18,34]. These results suggest that OD causes chronic stress, which affects the central nervous system, including the hypothalamic-pituitary-adrenocortical (HPA) axis and the sympathetic-adrenergic-medullary (SAM) system.…”

Section: Introductionmentioning

confidence: 96%

Occlusal disharmony suppresses long-term potentiation in the rat hippocampal CA1 region

Katö

Ono

Kubo

et al. 2010

J. Stomat. Occ. Med.

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Purpose: Recent studies have shown that occlusal disharmony (OD) causes deterioration in learning and memory via neuropathological processes in the mouse hippocampus.Methods: To elucidate the mechanism(s) by which this deterioration occurs, we examined the effect of a bite-raised condition, which induced OD, on long-term potentiation (LTP) in the rat hippocampal CA1 region. In addition, plasma levels of corticosterone and catecholamines, body weight, and food intake were measured to evaluate the involvement of the hypothalamic-pituitary-adrenal (HPA) axis and/or the sympathetic-adrenergic-medullary (SAM) system.Results: Ten days after bite-raising surgery, the amplitude of LTP was reduced by 62% in rats that underwent OD compared to sham-operated rats. The OD condition also caused a significant elevation in plasma levels of corticosterone and norepinephrine compared to control rats. Body weight decreased in OD rats, but the amount of food intake was not different between bite-raised and control conditions.Conclusion: These findings suggest that a disharmonious occlusal condition in rats induces not only impaired hippocampal plasticity but also chronic activation of the HPA axis and modulation of the autonomic nervous system.

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The bite-raised condition in aged SAMP8 mice induces dendritic spine changes in the hippocampal region

Cited by 20 publications

References 23 publications

Masticatory function and cognitive function

Masticatory function and cognitive function

The biological effects of occlusal trauma on the stomatognathic system – a focus on animal studies

Occlusal disharmony suppresses long-term potentiation in the rat hippocampal CA1 region

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