The blood copper isotopic composition is a prognostic indicator of the hepatic injury in Wilson disease

Abstract

Wilson disease (WD) is an autosomal recessive disorder of copper (Cu) metabolism. The gene responsible for WD, ATP7B, is involved in the cellular transport of Cu, and mutations in the...

Isotopic composition of serum zinc and copper in healthy children and children with autism spectrum disorder in North America

“…To our knowledge this is one of the first studies to measure copper and zinc isotopic fractionation in the serum of both children (25–46 months old) with and without autism spectrum disorder. While there has been a study that measured the δ 65 Cu in children with Wilson’s Disease and those without Wilson’s Disease, δ 66 Zn values were not measured ( Lamboux et al, 2020 ). Additionally, it is unclear if these samples were age and gender matched as was the case in our study.…”

“…In mice, an antibiotic treatment was shown to modulate the expression levels of copper transporter 1 (CTR-1) in intestinal epithelial cells, which induced a large isotope fractionation compared to wild type mice ( Miller et al, 2019 ). In humans, analyses have been done on the serum of adult patients and differences in serum copper isotopic composition have been observed in several types of cancers, Wilson’s disease, amyotrophic lateral sclerosis, liver cirrhosis, non-alcoholic liver fatty liver disease, and for those females with increased risk of preterm birth ( Balter et al, 2015 ; Télouk et al, 2015 ; Bondanese et al, 2016 ; Sauzéat et al, 2018 ; Lamboux et al, 2020 ; García-Poyo et al, 2021 ; Kazi Tani et al, 2021 ; Wang et al, 2022 ).…”

Metallome deregulation and health-related impacts due to long-term exposure to recent volcanic ash deposits: New chemical and isotopic insights

“…Independent of the amount of metals, the Cu and Zn isotopic compositions ( 65 Cu,  66 Zn) are promising tools that recently offer a more comprehensive view of several biological processes than concentrations alone such as aging 20,21,66 . They also turned out to be very promising tools for pointing out a disruption in the oxidative stress status 67 , a major pathogenetic event occurring in several liver disorders 68 , and more broadly for the diagnosis, prognosis and follow-up of patients suffering from severe pathologies like cancers 22,69 , neurodegenerative diseases 23,70,71 as well as severe hepatic syndromes [72][73][74][75] ; with the amplitude of the variations being likely linked to the severity of the disease 73,75 . Despite this proven interest, the use of  65 Cu and  66 Zn as a potential marker for health prevention have never been investigated in a volcanically active context.…”

A “turn-on” ESIPT fluorescence probe of 2-(aminocarbonyl)phenylboronic acid for the selective detection of Cu(ii)

“…Especially aer biological enrichment, excessive Cu(II) causes metabolic and neurological disorders, leading to rheumatoid arthritis, Wilson's syndrome, Parkinson's disease, and Alzheimer's disease. [1][2][3] Therefore, it is of great signicance to develop an efficient detection assay for Cu(II) in clinical diagnosis and disease prevention.…”