The Blood Platelet Release Reaction

Abstract

LIST OF ABBREVIATIONS ATP, ADP and AMP = adenosine tri-, di-and monophosphate. IMP = Inosine monophosphate. NEM = N-ethyl maleimide. EDTA = Ethylenediamino tetraacetate. NADPH = Nicotine adenine dinucleotide phosphate, reduced form. TCA = Trichloroacetic acid.

Current Concepts on Normal and Modified Platelet Aggregation

“…Simultaneously, Parmeggiani ( 1 7) was first to demonstrate the disappearance of the typical, osmiophilic storage organelles within the platelets under the influence of thrombin. This obviously correlates with the appearance in the surrounding medium of serotonin, adrenaline, adenine nucleotides, platelet factor 4, potassium, and calcium under the same conditions (9).…”

Effects of platelet release products on neutrophilic activity in human whole blood

“…Depending on the type of stimulus and experimental conditions, platelets have shown to either inhibit or stimulate neutrophillc functions [18,19]. Stimulated platelets release many low-molecular weight substances, such as ATP, ADP, GTP, GDP, 5HT, and calcium ions from their dense bodies [6,20] and also high-molecular weight substances such as platelet-derived growth factor, fibronectin, and b-TG from their agranules [6], and MAPPs [9 -14]. In addition, these platelets produce and release prostaglandins [21].…”

Platelet Function and Platelet Phospholipids in Patients With Hyperbetalipoproteinemia

“…Thrombosis often represents the final occluding event in atherosclerotic arteries, and there is good evidence for the transformation of mural thrombi into atherosclerotic lesions (9). During thrombiis formation a series of events take place, including 25-712993 adhesion and aggregation of platelets, release of platelet nucleotides and exposure of coagulation active phospholipids on the platelet surface (10). These platelet lipids participate in the coagulation process, eventually leading to fibrin formstion and consolidation of the thrombus.…”