The classical distinction between the natural and the artificial is gradually losing its original sharpness. Biotechnology can be used not only for therapeutic purposes but also to enhance human cognitive, emotional, moral, or physical abilities. This article discusses three of the most important socio-ethical issues related to the impact of neuroenhancement on individuals and on society. It closely examines threats to the principle of autonomy in the case of two selected technologies for neuroenhancement: the Brain – Computer Interface and gene technologies applied to the enhancement of other beings. The article also discusses the influence of social pressure on autonomous decision-making by individuals and whether social pressure is a sufficient reason for not accepting neuroenhancement. Finally, within the context of many concerns about the widening of social inequality as the result of the spread of enhancement practices, this article examines whether such disparities can be avoided and whether the principle of equal opportunities can be regarded as a sufficient criterion of equality.