The Body Mass Index, Blood Pressure, and Fasting Blood Glucose in Patients With Methamphetamine Dependence

Lv, Dezhao; Zhang, Meijuan; Jin, Xuru; Zhao, Jinbing; Han, Bong-Ho; Su, Hang; Zhang, Jie; Zhang, Xiangyang; Ren, Wenwei; He, Jincai

doi:10.1097/md.0000000000003152

Cited by 22 publications

(16 citation statements)

References 24 publications

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“…The levels of GLU and BMI were also significantly decreased in MA-dependent patients, which is in line with our literature published before. [ 17 ] Besides, various researches indicated that MA may contribute to lower BMI. [ 16 , 18 ] The decrease in the above indicators could be explained as below: first, MA-dependent patients suffer cognitive deficits and abnormal metabolic activity, which affect nutritional status.…”

Section: Discussionmentioning

confidence: 99%

The levels of triglyceride and total cholesterol in methamphetamine dependence

Zhang

Lv²,

Zhou³

et al. 2017

Medicine

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The serum triglyceride (TG) and total cholesterol (TC) levels have been reported altered in the traditional drug-dependence (such as marijuana and heroin). However, studies assessing the relationships among serum TC, TG, and methamphetamine (MA)-dependence have not been described well. In this study, our aim is to explore the serum TG and TC levels in large sample of MA-dependent patients. A retrospective study was conducted in 938 MA-dependent patients who were recruited between February 2, 2008 and March 11, 2013, with social characteristics and drug-dependence history (duration of MA use, routes of drug administration, and daily dose were collected). Then, the serum levels of TC, TG, glucose (GLU), body mass index (BMI), and blood pressure were measured among the participants. Meanwhile, 985 age- and gender-matched healthy people in the physical examination center were selected as control group. Compared with the control group, significant decreases of TC, TG, GLU, and BMI were observed in MA-dependent patients (P < 0.05). Besides, we found that the daily dose of MA use was associated with TC (β = −0.079, P = 0.015) and the duration of MA use was independently related to BMI (β = −0.071, P = 0.031). This study demonstrated that the levels of TC, TG, GLU, and BMI factors altered in the MA-dependent patients. In addition, there is a negative association between MA dependence and TC and BMI.

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Section: Discussionmentioning

confidence: 99%

The levels of triglyceride and total cholesterol in methamphetamine dependence

Zhang

Lv²,

Zhou³

et al. 2017

Medicine

Self Cite

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“…However, these did not account for observed HPA axis dysregulation among METH + HIV+ MSM. One previous study observed that meth users display lower blood glucose levels (Lv et al, 2016), but it did not measure insulin or account for HIV status. Results of the present study build upon these findings by demonstrating the meth-using MSM display lower HOMA-IR scores irrespective of HIV status compared to METH-HIV− men.…”

Section: | Discussionmentioning

confidence: 99%

“…Finally, some animal research demonstrates that acute meth administration stimulates the pancreas to secrete insulin (McMahon, Andersen, Feldman, & Schanberg, 1971), an effect that is augmented by a hyperthyroid state (McMahon, Feldman, & Schanberg, 1975). Although rising insulin levels lead to robust increases in plasma cortisol (Fehm et al, 1984), in one prior study chronic meth users displayed a lower blood glucose and body mass index (BMI) compared to nonusers (Lv et al, 2016). Taken together, syndemic burden and measures of glycemic metabolic functioning remain important possible confounders in examining HPA dysregulation among chronic meth users.…”

Section: | Introductionmentioning

confidence: 99%

Short circuit: Disaggregation of adrenocorticotropic hormone and cortisol levels in HIV‐positive, methamphetamine‐using men who have sex with men

Rodriguez

Jones

Kumar

2017

Human Psychopharmacology

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Results: There were no group differences in prevailing adrenocorticotropic hormone (ACTH) or cortisol levels, but the association between ACTH and cortisol was moderated by METH + HIV+ group (β = −0.19, p < .05). Compared to METH-HIV− men, METH + HIV+ MSM displayed 10% higher log 10 cortisol levels per standard deviation lower ACTH. Both groups of methamphetamine-using MSM had lower insulin resistance and greater syndemic burden (i.e., sleep disturbance, severe depression, childhood trauma, and polysubstance use disorder) compared to METH-HIV− men. However, the disaggregated functional relationship between ACTH and cortisol in METH + HIV+ MSM was independent of these factors. Conclusions:Further research is needed to characterize the bio-behavioral pathways that explain dysregulated HPA axis functioning in HIV-positive, methamphetamine-using MSM.

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“…This might be due to cognitive deficits, abnormal metabolic activity, duration of MA use, and improper oral health that affects food chewing and, thus, intake. 48 , 49 More frequent use of other types of drugs such as marijuana or sedatives showed a weak association with a lower BMI, although this association is statistically not significant. 39 , 50 …”

Section: Introductionmentioning

confidence: 85%

“…Methylamphetamine (MA), a relatively new psychostimulant (the second most widely used drug now after heroin, marijuana, and others) is associated with cardiac and hepatic pathology, neurological impairment, mood disorders, and malnutrition. 48 People dependent on MA have a lower BMI as compared with that of healthy individuals. This might be due to cognitive deficits, abnormal metabolic activity, duration of MA use, and improper oral health that affects food chewing and, thus, intake.…”

Section: Introductionmentioning

confidence: 99%

Nutritional status and eating habits of people who use drugs and/or are undergoing treatment for recovery: a narrative review

et al. 2020

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A comprehensive overview is presented of the nutritional issues faced by people who use drugs or are undergoing treatment for recovery. Chronic substance use affects a person’s nutritional status and body composition through decreased intake, nutrient absorption, and dysregulation of hormones that alter the mechanisms of satiety and food intake. Anthropometrics alone is not the best indicator of nutritional status, because this population has hidden deficiencies and disturbed metabolic parameters. Socioeconomic factors (eg, higher education, higher income, presence of a partner, living at home) positively affect nutritional status. Scarce available data on users undergoing treatment indicate improvement in anthropometric and metabolic parameters but with micronutrient intake remaining suboptimal. Weight gain is noted especially among women who use drugs and potentially increases their risk of relapse. Finally, specific amino acids and omega-3 fatty acids are promising in decreasing relapse and improving mental health during treatment; however, additional high-quality studies are needed. Nutrition intervention for people who use drugs or are undergoing treatment for recovery is underused; comprehensive programs addressing this population’s unique needs are necessary. Future research will identify which components are needed.

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The Body Mass Index, Blood Pressure, and Fasting Blood Glucose in Patients With Methamphetamine Dependence

Cited by 22 publications

References 24 publications

The levels of triglyceride and total cholesterol in methamphetamine dependence

The levels of triglyceride and total cholesterol in methamphetamine dependence

Short circuit: Disaggregation of adrenocorticotropic hormone and cortisol levels in HIV‐positive, methamphetamine‐using men who have sex with men

Nutritional status and eating habits of people who use drugs and/or are undergoing treatment for recovery: a narrative review

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