The bone mass (BM) and chronic cardiac decompensation (CCD) in an elderly population

Sant’Angelo, Antonino; Testai, M.; Mamazza, Grazia; Zuccaro, Carmela; Albani, Salvatore; Pavano, Salvatore; Cappello, Antonella; Sambataro, Domenico; Atteritano, Marco; Maugeri, D.

doi:10.1016/j.archger.2010.05.003

Cited by 4 publications

(2 citation statements)

References 40 publications

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“…Both fractures and CHF cause severe disability in elderly patients with repeated hospitalizations and longer hospital treatment periods, thus increasing economic costs significantly. According to some authors, over half of CHF patients (even relatively young) have low BMD, whilst the risk of osteoporosis-related fractures is 1.5-6 times higher with CHF versus the overall population [7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Bone Mineral Density and Metabolism in Very Elderly Patients with Congestive Heart Failure

Topolyanskaya

Osipovskaya²,

Lifanova

et al. 2019

SN Compr. Clin. Med.

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The study purpose was investigation of bone mineral density (BMD) and metabolism in very elderly patients with heart failure. The study enrolled 125 patients (aged 75-98 years) hospitalized with coronary artery disease (CAD). The study group comprised 61 patients with clinically significant congestive heart failure (CHF) and the control group-64 age-matched patients without CHF symptoms. The main exclusion criteria were any other diseases that could cause osteoporosis and administration of medications reducing BMD. Lumbar spine and proximal femur BMD was measured by dual-energy X-ray absorptiometry. Serum osteocalcin concentration was measured by immunechemiluminescence, beta-Cross Laps levelby electrochemiluminescence. BMD in the CHF patients was lower versus the control group. Largest differences were recorded in proximal femur: BMD in the CHF patients was 719.8 ± 188.2 mg/cm 3 versus 797.7 ± 161.7 mg/cm 3 (p = 0.02) in the control group. Greater differences in BMD were detected in female patients. Proximal femur BMD had normal values only in 5% of the CHF patients, in the control groupin 31% of cases (p = 0.003). Reduced osteoblast function was observed in CHF patients: the mean osteocalcin level in the CHF patients was 1.2 ± 1.7 ng/ml versus 4.2 ± 4.1 ng/ml (р = 0.03) in the control group. Mean β-Cross Laps level in the CHF patients reached 0.73 ± 0.4 ng/ml versus 0.4 ± 0.1 ng/ml (p = 0.003) in the control group. These study findings suggest that bone mineral density in very elderly CHF patients is noticeably lower versus the patient group similar in age and main diseases. This study has demonstrated significantly reduced osteoblast function in CHF patients and slight increase in bone resorption.

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Section: Introductionmentioning

confidence: 99%

Bone Mineral Density and Metabolism in Very Elderly Patients with Congestive Heart Failure

Topolyanskaya

Osipovskaya²,

Lifanova

et al. 2019

SN Compr. Clin. Med.

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“…Как переломы, так и ХСН, приводят к выраженной инвалидизации лиц пожилого возрас-та с неоднократными госпитализациями и удлинени-ем сроков стационарного лечения, что обусловливает весьма существенное увеличение экономических за-трат. По данным ряда авторов, более чем у половины больных ХСН (даже относительно молодого возраста) отмечены низкие показатели минеральной плотно-сти костной ткани, тогда как риск переломов, связан-ных с остеопорозом, при ХСН повышен в 1,5-6 раз, по сравнению с показателями в общей популяции [6][7][8][9][10].…”

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Mineral Density and Metabolism of Bone Tissue in Patients With Chronic Heart Failure Insufficiency of Senior Age

et al. 2017

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Heart Failure as a Risk Factor for Osteoporosis and Fractures

Aluoch

Jessee

Habal

et al. 2012

Curr Osteoporos Rep

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Although heart failure (HF) and osteoporosis are common diseases, particularly in elderly populations, patients with HF have an increased risk for osteoporosis. The relationship of HF with osteoporosis is modified by gender and the severity of HF. In addition, shared risk factors, medication use, and common pathogenic mechanisms affect both HF and osteoporosis. Shared risk factors for these 2 conditions include advanced age, hypovitaminosis D, renal disease, and diabetes mellitus. Medications used to treat HF, including spironolactone, thiazide diuretics, nitric oxide donors, and aspirin, may protect against osteoporosis. In contrast, loop diuretics may make osteoporosis worse. HF and osteoporosis appear to share common pathogenic mechanisms, including activation of the renin-angiotensin-aldosterone system, increased parathyroid hormone levels, and/or oxidative/nitrosative stress. HF is a major risk factor for mortality following fractures. Thus, in HF patients, it is important to carefully assess osteoporosis and take measures to reduce the risk of osteoporotic fractures.

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The bone mass (BM) and chronic cardiac decompensation (CCD) in an elderly population

Cited by 4 publications

References 40 publications

Bone Mineral Density and Metabolism in Very Elderly Patients with Congestive Heart Failure

Bone Mineral Density and Metabolism in Very Elderly Patients with Congestive Heart Failure

Mineral Density and Metabolism of Bone Tissue in Patients With Chronic Heart Failure Insufficiency of Senior Age

Heart Failure as a Risk Factor for Osteoporosis and Fractures

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