The booming business of hair loss

Castro, Ana Rita; Portinha, Carlos; Logarinho, Elsa

doi:10.1016/j.tibtech.2022.12.020

Cited by 6 publications

(2 citation statements)

References 13 publications

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“…The worldwide market for alopecia reached $7.6 billion in 2020 and is forecasted to reach $13 billion by 2028. 33 In spite of the tremendous market size, the curative effect of current alopecia treatment is unsatisfactory.…”

Section: Discussionmentioning

confidence: 99%

Hair regeneration using microneedle-assisted human basic fibroblast growth factor

Xin,

Hei,

Lai

et al. 2023

JAPLR

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Hair loss has afflicted numerous patients for several decades. However, the current drug treatment is only effective for specific types of alopecia and their efficacy is limited. Additionally, the cost of hair transplant surgery is relatively high, making it unaffordable for some patients. In this study, we propose a new treatment method using microneedles and growth factors to alleviate alopecia. The results of our study demonstrate that patients receiving human basic fibroblast growth factor (hbFGF) therapy experienced significant hair regeneration. Both male and female patients responded positively to the growth factor treatment, with males showing better results. Importantly, microneedle-assisted hbFGF therapy can be universally applied to androgenetic alopecia, alopecia areata, and telogen effluvium. In summary, this study presents a novel and highly effective method that shows great potential for treating alopecia, with high levels of safety and efficacy.

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Section: Discussionmentioning

confidence: 99%

Hair regeneration using microneedle-assisted human basic fibroblast growth factor

Xin,

Hei,

Lai

et al. 2023

JAPLR

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“…It may also cause hypertrichosis, which is unacceptable to many women. Given the significant negative effects that AGA on patient quality of life, it is unsurprising that billions of dollars are spent yearly on hair loss remedies globally [6] and that patients turn to the media for updates on advancements in hair loss treatments [7]. There is an established need for alternative therapies for AGA that demonstrates clinical efficacy, ease of use, and minimal side effects to improve patient compliance.…”

Section: Introductionmentioning

confidence: 99%

Increased Interest in Oral Minoxidil for Hair Loss Treatment Following Publication of August 2022 New York Times Article: A Google Trends Analysis

Desir,

Desai,

Lipner

2023

Skin Appendage Disord

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Introduction: Androgenetic alopecia (AGA) is the most common form of hair loss, with negative impact on patient quality of life. Oral minoxidil is used off-label for AGA treatment. We hypothesized increased public interest in oral minoxidil for hair loss treatment following the New York Times (NYT) Article on oral minoxidil: “An Old Medicine Grows New Hair for Pennies a Day, Doctors Say.” The objective of this study was to quantify interest in oral minoxidil for hair loss treatment before and after the NYT article and help inform dermatologists about treatments of interest to their patients. Method: We performed a cross-sectional analysis of Google Trends evaluating relative prevalence of “oral minoxidil,” “minoxidil,” “hair loss,” and “Rogaine®” 2/2022–5/2023. t tests compared mean search volume and linear regression analysis quantified changes in public interest over time. Results: Oral minoxidil and minoxidil search volumes increased from 0.86 to 3.00 and 22.43 to 32.60, respectively, before and after the NYT article (both p < 0.05). Minoxidil searches continually increased by 500,000 searches per month (p < 0.001). Conclusions: There was a significant and sustained increase in Google searches for oral minoxidil after publication of the NYT article, indicating increased patient interest. Larger clinical trials are needed to provide evidence-based care to AGA patients.

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Rational Design of Human Hair Keratin−Driven Proteins for Hair Growth Promotion

Zhang,

Qing,

et al. 2024

Adv Healthcare Materials

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Keratins, the most abundant proteins in human hair, are excellent hair nutrients for growth. However, the complex components of keratin extract hinder their mechanism investigation, and the pure recombinant keratin with poor solubility limited its hair growth promotion efficiency. Here, the water−soluble recombinant keratins (RKs) of K31 and K81 are rationally designed through QTY Code methodology, which are then used to fabricate the microneedles to study the effect of keratin on hair growth. Interestingly, it is discovered that more than 40% of the hair follicles (HFs) in the RK81QTY group entered the anagen on day 12 and the diameter of new hair is 15.10 ± 2.45 µm, which significantly promoted growth and development of HFs and improved new hair quality compared to RK31QTY. Water‐soluble RKs significantly enhanced HFs activity and de novo regeneration of robust hairs compared to extract and minoxidil by upregulating the PI3K/AKT/Nf−κB signaling axis. These findings highlight the potential of designing solubilized recombinant keratins with distinct properties to improve therapeutical effects and open new avenues to designing keratin−based proteins.

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The booming business of hair loss

Cited by 6 publications

References 13 publications

Hair regeneration using microneedle-assisted human basic fibroblast growth factor

Hair regeneration using microneedle-assisted human basic fibroblast growth factor

Increased Interest in Oral Minoxidil for Hair Loss Treatment Following Publication of August 2022 New York Times Article: A Google Trends Analysis

Rational Design of Human Hair Keratin−Driven Proteins for Hair Growth Promotion

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