The Brain Connectome for Chinese Reading

Guo, Wanwan; Geng, Shujie; Cao, Miao; Feng, Jianfeng

doi:10.1007/s12264-022-00864-3

Cited by 10 publications

(4 citation statements)

References 157 publications

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“…Remarkably, the middle frontal gyrus (MFG) emerged as the most prominently engaged area, showing consistent activation during language and semantic processing across all subjects in this study. This observation reinforces existing literature that positions the MFG as a pivotal hub for Chinese reading [20][21][22][23] and semantic representations [24]. Specifically, the left hemisphere's MFG is closely associated with the orthographic processing required for lexical decision-making tasks, reflecting the unique structure of Chinese characters that incorporate strokes and radicals into a square form to represent syllables and morphemes of the spoken language [25].…”

Section: Identifying Cortical Regions Engaged In Semantic Processingsupporting

confidence: 84%

“…The cognitive processing of these characters involves visuospatial analysis and memory areas where the MFG is actively engaged [24, 42, 43]. Previous studies also suggested that the MFG’s involvement in visuospatial processing might be more pronounced in Chinese due to the logographic nature of its writing system [21, 23, 44, 45], whereas its role in phonological and syntactic processing might be more emphasized in English. These observations confirmed the effectiveness of our approach in tracking the voxel-wise contributions to language production and semantic processing, which also enhances our comprehension of the underlying decoding mechanisms.…”

Section: Discussionmentioning

confidence: 99%

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Decoding Continuous Character-based Language from Non-invasive Brain Recordings

Zhang,

Zheng,

Yin

et al. 2024

Preprint

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Deciphering natural language from brain activity through non-invasive devices remains a formidable challenge. Previous non-invasive decoders either require multiple experiments with identical stimuli to pinpoint cortical regions and enhance signal-to-noise ratios in brain activity, or they are limited to discerning basic linguistic elements such as letters and words. We propose a novel approach to decoding continuous language from single-trial non-invasive fMRI recordings, in which a three-dimensional convolutional network augmented with information bottleneck is developed to automatically identify responsive voxels to stimuli, and a character-based decoder is designed for the semantic reconstruction of continuous language characterized by inherent character structures. The resulting decoder can produce intelligible textual sequences that faithfully capture the meaning of perceived speech both within and across subjects, while existing decoders exhibit significantly inferior performance in cross-subject contexts. The ability to decode continuous language from single trials across subjects demonstrates the promising applications of non-invasive language brain-computer interfaces in both healthcare and neuroscience.

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Section: Identifying Cortical Regions Engaged In Semantic Processingsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Decoding Continuous Character-based Language from Non-invasive Brain Recordings

Zhang,

Zheng,

Yin

et al. 2024

Preprint

Self Cite

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“…2022 ; Feng et al. 2022 ; Guo et al. 2022 ), which suggest the potential involvement of these regions in comprehensive processes such as visual word form analysis and character–syllable conversion.…”

Section: Discussionmentioning

confidence: 99%

Phonological properties of logographic words modulate brain activation in bilinguals: a comparative study of Chinese characters and Japanese Kanji

Lin,

Li,

et al. 2024

Cerebral Cortex

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The brain networks for the first (L1) and second (L2) languages are dynamically formed in the bilingual brain. This study delves into the neural mechanisms associated with logographic–logographic bilingualism, where both languages employ visually complex and conceptually rich logographic scripts. Using functional Magnetic Resonance Imaging, we examined the brain activity of Chinese–Japanese bilinguals and Japanese–Chinese bilinguals as they engaged in rhyming tasks with Chinese characters and Japanese Kanji. Results showed that Japanese–Chinese bilinguals processed both languages using common brain areas, demonstrating an assimilation pattern, whereas Chinese–Japanese bilinguals recruited additional neural regions in the left lateral prefrontal cortex for processing Japanese Kanji, reflecting their accommodation to the higher phonological complexity of L2. In addition, Japanese speakers relied more on the phonological processing route, while Chinese speakers favored visual form analysis for both languages, indicating differing neural strategy preferences between the 2 bilingual groups. Moreover, multivariate pattern analysis demonstrated that, despite the considerable neural overlap, each bilingual group formed distinguishable neural representations for each language. These findings highlight the brain’s capacity for neural adaptability and specificity when processing complex logographic languages, enriching our understanding of the neural underpinnings supporting bilingual language processing.

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“…The left middle frontal gyrus is crucial for literacy development. In Chinese reading, the left middle frontal gyrus serves as a specialized hub region that connects ventral and dorsal pathways ( Guo et al, 2022 ). In dyslexic Chinese readers, structural and functional impairments in the left middle frontal gyrus contrast with the left temporoparietal regions in alphabetic languages ( Yang Y. et al, 2013 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of the SNAP-25 Mnll variant on hippocampal functional connectivity in children with attention deficit/hyperactivity disorder

Huang

Fateh

Zhao

et al. 2023

Front. Hum. Neurosci.

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ObjectivesAttention-deficit/hyperactivity disorder (ADHD) is one of the most widespread and highly heritable neurodevelopmental disorders affecting children worldwide. Although synaptosomal-associated protein 25 (SNAP-25) is a possible gene hypothesized to be associated with working memory deficits in ADHD, little is known about its specific impact on the hippocampus. The goal of the current study was to determine how variations in ADHD’s SNAP-25 Mnll polymorphism (rs3746544) affect hippocampal functional connectivity (FC).MethodsA total of 88 boys between the ages of 7 and 10 years were recruited for the study, including 60 patients with ADHD and 28 healthy controls (HCs). Data from resting-state functional magnetic resonance imaging (rs-fMRI) and clinical information were acquired and assessed. Two single nucleotide polymorphisms (SNP) in the SNAP-25 gene were genotyped, according to which the study’s findings separated ADHD patients into two groups: TT homozygotes (TT = 35) and G-allele carriers (TG = 25).ResultsBased on the rs-fMRI data, the FC of the right hippocampus and left frontal gyrus was evaluated using group-based comparisons. The corresponding sensitivities and specificities were assessed. Following comparisons between the patient groups, different hippocampal FCs were identified. When compared to TT patients, children with TG had a lower FC between the right precuneus and the right hippocampus, and a higher FC between the right hippocampus and the left middle frontal gyrus.ConclusionThe fundamental neurological pathways connecting the SNAP-25 Mnll polymorphism with ADHD via the FC of the hippocampus were newly revealed in this study. As a result, the hippocampal FC may further serve as an imaging biomarker for ADHD.

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The Brain Connectome for Chinese Reading

Cited by 10 publications

References 157 publications

Decoding Continuous Character-based Language from Non-invasive Brain Recordings

Decoding Continuous Character-based Language from Non-invasive Brain Recordings

Phonological properties of logographic words modulate brain activation in bilinguals: a comparative study of Chinese characters and Japanese Kanji

Effects of the SNAP-25 Mnll variant on hippocampal functional connectivity in children with attention deficit/hyperactivity disorder

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