The Brain-Derived Neurotrophic Factor Val66Met Polymorphism, Delivery Method, Birth Weight, and Night Sleep Duration as Determinants of Obesity in Vietnamese Children of Primary School Age

Trang

et al. 2023

Preprint

Background: The Beta-3 adrenergic receptor (ADRB3) gene codes for the β3 adrenergic receptor involved in control of energy balance by altering lipolysis and thermogenesis in adipocytes. A missense mutation in codon 64 of this gene caused the replacement Trp with Arg (Trp64Arg/rs4994). A cross-sectional study was performed with the joining of 708 non-obese children and 304 obese children in Hanoi. The objective of our study was to find out the association between rs4994 polymorphism of ADRB3 and obesity in Hanoi preschool-age children, considering their eating behaviors. Results: The frequency of C allele in obese group was 16.4%, higher than that in the control group (11.7%, p = 0.003). After conducting univariate analysis, and multivariate analysis adjusted for eating behaviors, a significant association between rs4994 polymorphism and obesity was observed (p < 0.05). Conclusions: This study indicated that ADRB3-rs4994 polymorphism can be considered as an independent risk factor for obesity in Vietnamese preschool children.

Section: Introductionsupporting

confidence: 54%

The association between rs4994 polymorphism of the Beta3-Adrenergic Receptor with obesity in Vietnamese preschool-age children, independently of eating behaviors

Trang

et al. 2023

Preprint

“…The remaining 393 articles were read in full, with 281 excluded: 120 did not meet the age criteria (5‐13 years); 8 were of clinical or nonfree‐living population groups; 8 did not measure weight status objectively; 68 did not analyze the association between sleep‐obesity; and 77 were excluded either due to being non‐English, not peer‐reviewed, review/meta‐analysis, duplicate data, or a conference abstract/other unpublished data. This left 112 articles deemed relevant and included in the analysis (Table ) …”

Section: Resultsmentioning

confidence: 99%

Sleep and obesity among children: A systematic review of multiple sleep dimensions

et al. 2020

Summary The objectives were to systematically investigate the multiple dimensions of sleep and their association with overweight or obesity among primary school‐aged children. CINHAL, PsycINFO, SPORTDiscus, Medline, Cochrane, Embase, and PubMed databases were searched for papers reporting on an association between children's sleep and weight status. Studies on clinical populations, published in languages other than English, without objectively measured weight status, or where weight status was reported outside the outlined age bracket (5‐13 years) were excluded. A total of 34 248 citations were extracted from our systematic search protocol, of which 112 were included for detailed review. Compared with sleep duration, of which 86/103 articles found a significant inverse association between sleep duration and measured weight status, few studies examined other dimensions of sleep, such as quality, efficiency and bed/wake times, and relationship with weight status. Where studies existed, variation in defining and measurement of these dimensions restricted comparison and potentially influenced discrepancies across results. Overall, the findings of this review warrant the need for further research of the outlined dimensions of sleep. Future research would benefit from clarity on definitions across the different dimensions, along with the use of valid and reliable tools.

“…The Ethics Committee of the National Institute of Nutrition approved this study No. 12-01/HĐĐĐ in 2011 [13].…”

Section: Subjects Of Studymentioning

confidence: 99%

Associations of single nucleotide polymorphism rs17782313 in melanocortin 4 receptor gene with anthropometric indices in normal and obesity primary school children in Hanoi

Tuyet¹

2018

MPS

Melanocortin-4 receptor (MC4R) has roles in regulating food intake and energy balance. A number of studies have reported that variant rs17782313 is significantly associated with obesity in many populations. However, their contribution to obesity in the Vietnamese population is not fully described. The purpose of the present study was to evaluate the association of rs17782313 with anthropometric indices and obesity in the Vietnamese children population. A case-control study was conducted on 559 children aged 6-11 years (278 obese cases and 281 normal controls). The nutrition status of the children was classified using both criteria of International Obesity Task Force 2000 and World Health Organization 2007. The results showed that in normal group, the data of z score of weight for age was highest in CC genotype group and was lowest in TT genotype group (0.11 and -0.38 respectively, P=0.023). In obese group, the waist hip ratio was lowest in TT genotype group and the highest one was in CC genotype group (0.93 and 0.97 respectively, P=0.031). Our findings indicate that the variant rs17782313 near MC4R is likely to have an impact on the changing of weight and central obesity in the Vietnamese children.