While considerable attention has been directed to the national-level impacts of global value chains, far less attention has been focused on the way in which global production fragmentation has affected regional economies. Using some measures derived from a multiregional, multisectoral input-output model, this paper analyzes the position and share of EU regions in Global Value Chains (GVC). The spatial determinants of these two dimensions are explored using spatial econometric methods to capture the influence of neighboring regions on these outcomes. Empirically, the focus is on a set of NUTS2 European regions for the most recent year (2010) of the EUREGIO database. Our results confirm the hypothesis of spatial dependence between regions conditioning the engagement and position GVCs, suggesting that global production processes are influenced by regional and local factors. In particular, spatial spillover effects play a significant role conditioned by both geographical proximity and similarity of production structures. The results show that sharing certain characteristics, some of them associated to their degree of proximity and the neighbouring situation of regions condition their specialization, participation and positioning in GVC, generating some