The bromine content of human tissue

Abstract

1. A comparison of human tissue organo-bromine residues has been made from specimens obtained in the UK, West Germany and Holland.2. These findings, in conjunction with previous animal studies and with the geographical differences in the use of brominated vegetable oils as food additives, suggest that the high bromine levels found in the fat of tissues from UK children are due to the use of these compounds.

Bromide and N-acetyl-S-(n-propyl)-l-cysteine in urine from workers exposed to 1-bromopropane solvents from vapor degreasing or adhesive manufacturing

“…Bromide analysis in urine, however, may not be ideal for evaluating very low level occupational exposure to 1-BP because background levels are influenced by dietary sources, especially seafood, certain soft drinks, and food prepared with brominated vegetable oil or flour as well as pharmaceutical medications and over-the-counter products containing bromine (Crampton et al 1971;Horowitz 1997;Ryan and Baumann 1999;Zhang 2001). Mercapturic acid conjugates, which have been used as biomarkers of exposure to halogenated compounds (Van Welie et al 1992;De Rooij et al 1998), may prove more specific for low occupational exposure to 1-BP than urinary Br (-) .…”

Mass spectra of methyl esters of brominated fatty acids and their presence in soft drinks and cocktail syrups

“…Toxicological data on BVO are barely available . However, brominated fatty acids have been shown to accumulate in the body lipids of rats, pigs, and humans . Shorter chain metabolites of brominated fatty acids have also been identified .…”

“…Shorter chain metabolites of brominated fatty acids have also been identified . Lipid‐bound bromine levels were higher in humans from countries using BVO in soft drinks . High consumption of BVO‐containing soft drinks has been found to generate bromism .…”