The Bronchial Circulation

Aviado, Domingo M.

doi:10.1016/b978-0-08-010988-6.50014-7

Cited by 26 publications

(30 citation statements)

References 130 publications

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“…The changes of PVD and PVR after the injection of atropine appear consonant with this suggestion for the following reasons: 1) Relaxation resulting from the parasympatholytic action of atropine is probably important for the bronchial musculature, but, on the basis of present knowledge (80), cannot be postulated for the human lung vessels. Even a direct action of atropine on pulmonary vessels appears unlikely, since no evidence has been collected in man or dog that indicates pulmonary vasodilatation after atropine administration (81)(82)(83).…”

Section: Discussionmentioning

confidence: 71%

Pulmonary vascular distensibility and lung compliance as modified by dextran infusion and subsequent atropine injection in normal subjects.

Giuntini¹,

Maseri²,

Bianchi³

1966

J. Clin. Invest.

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Little information is available on the pressurevolume relationship of the human pulmonary circulation. Observations have been almost exclusively confined to limited groups of cardiac patients (1-6) in whom coexistence of extravascular alterations, such as interstitial perivascular edema (7, 8), may hinder the interpretation of the results. On the other hand, extrapolation to man of animal studies on the pressure-volume characteristics of the whole pulmonary vascular bed or part of it is not always warranted because of species variation and wide experimental differences. Finally, the combined evaluation of pulmonary vascular resistance and transmural pressure may provide information on the distensibility of resistive vessels but does not allow deductions on the distensibility of the pulmonary circulation as a whole, since the distribution of volume does not parallel that of resistance.Previous reports have shown that the infusion of a plasma expander raised the pulmonary arterial and wedge pressures to the same extent (9); if the change in pressure was assumed to be practically uniform throughout the bed, such an infusion seemed to provide an opportunity to assess the compliance of the pulmonary vascular bed by determining the ratio of the change in volume to the change in pressure.The values of the distensibility of the pulmonary circulation obtained with dextran infusion during the first studies were thought to be exceedingly low. We then decided to test some drug that could enhance the distensibility of the pulmonary vascular bed. Atropine sulfate, which was

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Section: Discussionmentioning

confidence: 71%

Pulmonary vascular distensibility and lung compliance as modified by dextran infusion and subsequent atropine injection in normal subjects.

Giuntini¹,

Maseri²,

Bianchi³

1966

J. Clin. Invest.

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“…Aviado (1965) described a dual effect of acetylcholine: vasodilatation at low concentrations and vasoconstriction with high doses. In our study, only contractile actions were recorded irrespective of the basal tone of the vessel strip, although high concentrations of carbachol were required (>1 x 10-4 M).…”

Section: Discussionmentioning

confidence: 99%

“…It delivers nutrients and oxygen to the lung parenchyma, nervous structures and the conducting airways (Aviado, 1965). An efficient bronchial circulation is essential for proper functioning of the lung tissue.…”

Section: Introductionmentioning

confidence: 99%

Preliminary Pharmacological Characterization of the Bovine Isolated Bronchial Artery Strip: A New Preparation

Arowolo

Eyre

1980

British J Pharmacology

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1This paper describes a preliminary pharmacological study of the isolated helical strip of bovine bronchial artery under isotonic conditions in Krebs-Henseleit solution. 2 The tissue contracted to histamine and 5-hydroxytryptamine (5-HT), actions which were selectively antagonized by mepyramine and methysergide respectively. Histamine was not inhibited by metiamide and 5-HT was not affected by morphine.3 Slow reacting substance of anaphylaxis (SRS-A), prostaglandin F2. (PGF2X) and PGE2 were spasmogenic, whereas PGE1 caused relaxation. No potential antagonists of these agents were tested. 4 Carbachol, at all concentrations, caused contractions of the bronchial artery which were completely, irreversibly blocked by atropine. 5 The spasmogenic action of phenylephrine was selectively blocked by dibenamine. Vessel strips which were partially contracted to histamine, relaxed to isoprenaline and salbutamol. The action of isoprenaline was inhibited similarly by either propranolol or practolol. The evidence therefore suggests the presence of functional a, I, and #2-adrenoceptors.

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“…There have been several suggestions that the bronchial artery may participate in obstructive pulmonary disease (Deletonia de la Mata & Aviado, 1961;McLaughlin, Tyler & Canada, 1961;Aviado, 1965;Holm, 1972;Arowolo & Eyre, 1979;1980), i.e. local inflammation might occlude the vessel and reduce the blood supply (oxygen and nutrients) to the airways and parenchyma.…”

mentioning

confidence: 99%

Anaphylactic contraction (Schultz‐Dale reaction) of the bovine bronchial artery in vitro

Alexander

Eyre

Gordon

1983

British J Pharmacology

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Bronchial arteries from sensitized calves contracted on antigenic challenge in the absence and presence of selected anti-allergic drugs and autonomic agents in vitro. Anaphylactic reactivity was inhibited by tripelennamine, isoprenaline and aminophylline, and potentiated by indomethacin and dopamine. Disodium cromoglycate, compound FPL 55712 and ketanserin failed to inhibit anaphylactic contraction.

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The Bronchial Circulation

Cited by 26 publications

References 130 publications

Pulmonary vascular distensibility and lung compliance as modified by dextran infusion and subsequent atropine injection in normal subjects.

Pulmonary vascular distensibility and lung compliance as modified by dextran infusion and subsequent atropine injection in normal subjects.

Preliminary Pharmacological Characterization of the Bovine Isolated Bronchial Artery Strip: A New Preparation

Anaphylactic contraction (Schultz‐Dale reaction) of the bovine bronchial artery in vitro

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