The building blocks of mammalian lung development

Abstract

Progress has recently been made in identifying progenitor cell populations in the embryonic lung. Some progenitor cell types have been definitively identified by lineage-tracing studies. However, others are not as well characterized and their existence is inferred on the basis of lung morphology, or mutant phenotypes. Here, I focus on lung development after the specification of the initial lung primordium. The evidence for various lung embryonic progenitor cell types is discussed and future experiments are suggested. The regulation of progenitor proliferation in the embryonic lung, and its coordinate control with morphogenesis, is also discussed. In addition, the relationship between embryonic and adult lung progenitors is considered. Developmental Dynamics 240:463-476,

SoxF Transcription Factors Are Positive Feedback Regulators of VEGF Signaling

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EngineeringDe NovoAssembly of Fetal Pulmonary Organoids

“…25,[52][53][54][55][56][57] The central role of VEGF-A among these signals has been demonstrated in numerous experimental contexts. 21,23,33,34,[58][59][60] In line with findings from embryological studies, endothelial network morphogenesis in our in vitro constructs is critically dependent on VEGF-A, as evidenced by near-complete ablation of network formation with 2 mg/mL of sVEGFR1-Fc (Fig.…”

Gpr177 regulates pulmonary vasculature development

“…The proximal-distal patterning of the epithelial progenitor cells seems unaffected, as shown by normal distribution of Sox2 + and Sox9 + cells in the E14.5 mutant lungs ( Fig. 2A) (Que et al, 2009;Rawlins, 2011). Similarly, Sox2 expression is maintained in the proximal airways, while Sox9 is lost in the distal lung in both mutants and controls at E18.5 (Fig.…”