The burden of chronic kidney disease in Australian patients with type 2 diabetes (the NEFRON study)

Thomas, Merlin C.; Weekes, Andrew; Broadley, Olivia J; Cooper, Mark E.; Th, Mathew

doi:10.5694/j.1326-5377.2006.tb00574.x

Cited by 25 publications

(54 citation statements)

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“…In several studies, when compared with the albuminuric renal insufficiency group, nonalbuminuric renal insufficiency group was marked by showing a preponderance of female sex, older age, higher HDL-C, and possibly better prognosis [73031]. In our study, nonalbuminuric stage ≥3 CKD group had shorter diabetic duration, lower concentrations of HbA1c, HDL-C, and hsCRP, lower prevalent rates of retinopathy and previous CVD, and higher rate of treatment with ACEIs/ARBs compared with albuminuric stage ≥3 CKD group.…”

Section: Discussionmentioning

confidence: 99%

“…Although it may occur even if not have significant renal damages, microalbuminiuria is considered to be a clinically reliable marker for renal microvascular lesions [3233]. On the other hand, eGFR had an inverse association with the indicators of both extrarenal and intrarenal atherosclerotic lesions [734]. Vascular cell dysfunction and resulting atherosclerotic changes are specious pathophysiologic mechanism for the connection between declined renal function with albuminuria and cardiovascular death [2533].…”

Section: Discussionmentioning

confidence: 99%

“…Lately, Soveri et al [6] showed that it may be possible to detect a rise in the risk of CVD development and cardiovascular death in those with eGFR of <90 mL/min/1.73 m 2 . On the average, 30% of diabetic patients will develop chronic renal disease [7], and nonalbuminuric form of renal insufficiency is also found [89]. The two large-scale clinical trials have analyzed and shown the self-determining influences of both increased degree of albuminuria and decreased renal function on the development of CVD and cardiovascular death [1011].…”

Section: Introductionmentioning

confidence: 99%

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Prevalent Rate of Nonalbuminuric Renal Insufficiency and Its Association with Cardiovascular Disease Event in Korean Type 2 Diabetes

Lee

et al. 2016

Endocrinol Metab

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BackgroundNonalbuminuric renal insufficiency is a unique category of diabetic kidney diseases. The objectives of the study were to evaluate prevalent rate of nonalbuminuric renal insufficiency and to investigate its relationship with previous cardiovascular disease (CVD) event in Korean patients with type 2 diabetes mellitus (T2DM).MethodsLaboratory and clinical data of 1,067 subjects with T2DM were obtained and reviewed. Study subjects were allocated into four subgroups according to the CKD classification. Major CVD events were included with coronary, cerebrovascular, and peripheral vascular events.ResultsNonalbuminuric stage ≥3 CKD group, when compared with albuminuric stage ≥3 CKD group, had shorter diabetic duration, lower concentrations of glycated hemoglobin, high density lipoprotein cholesterol, and high-sensitivity C-reactive protein, lower prevalent rates of retinopathy and previous CVD, and higher rate of treatment with angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers. Nonalbuminuric stage ≥3 CKD group showed a greater association with prior CVD events than no CKD group; however, albuminuric stage ≥3 CKD group made addition to increase prevalence of prior CVD events significantly when CKD categories were applied as covariates. Association of prior CVD events, when compared with normal estimated glomerular filtration rate (eGFR) and nonalbuminuria categories, became significant for declined eGFR, which was higher for eGFR of <30 mL/min/1.73 m2, and albuminuria.ConclusionThe results show that subjects with nonalbuminuric stage ≥3 CKD is significantly interrelated with occurrence of prior CVD events than those with normal eGFR with or without albuminuria. Comparing with normal eGFR and nonalbuminuria categories, the combination of increased degree of albuminuria and declined eGFR is becoming significant for the association of prior CVD events.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prevalent Rate of Nonalbuminuric Renal Insufficiency and Its Association with Cardiovascular Disease Event in Korean Type 2 Diabetes

Lee

et al. 2016

Endocrinol Metab

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“…For example, the renal function of some patients with diabetes is characterized by a decreased GFR and little or no albuminuria. 74,75 …”

Section: Pathogenesis Of Diabetic Nephropathymentioning

confidence: 99%

Contrast-induced acute kidney injury and diabetic nephropathy

2010

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“…Consequenctly, DN is associated with reduced life expectancy and increased morbidity, thereby imposing a significant burden on national healthcare system in diabetic care [2,3]. …”

Section: Introductionmentioning

confidence: 99%

Aberrant DNA methylation patterns in diabetic nephropathy

Maghbooli

Larijani

Emamgholipour

et al. 2014

J Diabetes Metab Disord

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BackgroundThe aim of this study was to evaluate whether global levels of DNA methylation status were associated with albuminuria and progression of diabetic nephropathy in a case-control study of 123 patients with type 2 diabetes- 53 patients with albuminuria and 70 patients without albuminuria.MethodsThe 5-methyl cytosine content was assessed by reverse phase high pressure liquid chromatography (RP-HPLC) of peripheral blood mononuclear cells to determine individual global DNA methylation status in two groups.ResultsGlobal DNA methylation levels were significantly higher in patients with albuminuria compared with those in normal range of albuminuria (p = 0.01). There were significant differences in global levels of DNA methylation in relation to albuminuria (p = 0.028) and an interesting pattern of increasing global levels of DNA methylation in terms of albuminuria severity.In patients with micro- and macro albuminuria, we found no significant correlations between global DNA methylation levels and duration of diabetes (p > 0.05). In both sub groups, there were not significant differences between global DNA methylation levels with good and poor glycaemic control (p > 0.05). In addition, in patients with albuminuria, no differences in DNA methylation levels were observed between patients with and without other risk factors including age, gender, hypertension, dyslipidaemia and obesity.ConclusionsThese data may be helpful in further studies to develop novel biomarkers and new strategies for clinical care of patients at risk of diabetic nephropathy.

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The burden of chronic kidney disease in Australian patients with type 2 diabetes (the NEFRON study)

Cited by 25 publications

References 0 publications

Prevalent Rate of Nonalbuminuric Renal Insufficiency and Its Association with Cardiovascular Disease Event in Korean Type 2 Diabetes

Prevalent Rate of Nonalbuminuric Renal Insufficiency and Its Association with Cardiovascular Disease Event in Korean Type 2 Diabetes

Contrast-induced acute kidney injury and diabetic nephropathy

Aberrant DNA methylation patterns in diabetic nephropathy

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