The Burden of Repeated Mood Episodes in Bipolar I Disorder

Peters, Amy T.; West, Amy E.; Eisner, Lori; Baek, Jihyun; Deckersbach, Thilo

doi:10.1097/nmd.0000000000000425

Cited by 40 publications

(14 citation statements)

References 34 publications

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“… Clinical and neurocognitive characteristics of persons with BD were predictive of work functioning over the 5-year study. Peters et al, 2016 64 Cross-sectional survey [N=909 (BD-I)] NA Multivariate models showed increases in the total number of lifetime mood episodes were associated with small, but significantly higher likelihood of permanent disability ( b =0.01) and unemployment ( b =0.01). Recurrent mood episodes and repeated depressive episodes (vs mania) were a consistent predictor of functional impairments in patients with BD-I.…”

Section: Resultsmentioning

confidence: 99%

“… 63 – 65 Moreover, an increased number of lifetime mood episodes was associated with higher likelihood of permanent disability and unemployment. 64 …”

Section: Resultsmentioning

confidence: 99%

“…Functional impairments among individuals with BD-I were associated with increased risk of unemployment or becoming disabled. 31 , 60 , 64 This risk was higher in persons who experienced recurrent mood episodes. 64 High direct medical costs, particularly for acute care, were reported for patients with BD-I specifically.…”

Section: Discussionmentioning

confidence: 95%

“… 31 , 60 , 64 This risk was higher in persons who experienced recurrent mood episodes. 64 High direct medical costs, particularly for acute care, were reported for patients with BD-I specifically. 31 , 33 , 34 , 40 Among those with greater HCRU, nonadherence to pharmacotherapy and presence of comorbid conditions (eg, substance use disorder, hypertension) contributed to higher cost burden.…”

Section: Discussionmentioning

confidence: 95%

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<p>The Economic Burden of Bipolar Disorder in the United States: A Systematic Literature Review</p>

Bessonova

Ogden

Doane

et al. 2020

CEOR

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Bipolar disorder (BD) is a mood disorder with subtypes characterized by episodes of mania, hypomania, and/or depression. BD is associated with substantial economic burden, and the bipolar I disorder (BD-I) subtype is associated with high medical costs. This review further evaluated the economic burden of BD and BD-I in the United States (US), describing health-care resource utilization (HCRU) and sources of direct medical and indirect costs. Data were obtained from systematic searches of MEDLINE ® , EMBASE ® , and National Health Service Economic Evaluation Database. Citations were screened to identify primary research studies (published 2008–2018) on the economic burden of BD/BD-I or its treatment in real-world settings. Reported costs were converted to 2018 US dollars. Of identified abstracts (N=4111), 56 studies were included. The estimated total annual national economic burden of BD/BD-I was more than $195 billion, with approximately 25% attributed to direct medical costs. Individuals with BD/BD-I used health-care services more frequently and had higher direct medical costs than matched individuals without the disease. Drivers of higher direct costs included frequent psychiatric interventions, presence of comorbid medical/psychiatric conditions, and both suboptimal medication adherence and clinical management. Indirect costs (eg, unemployment, lost work productivity for patients/caregivers) accounted for 72–80% of the national economic burden of BD/BD-I. Different definitions for study populations and cost categories limited comparisons of economic outcomes. This review builds on existing literature describing the economic burden of BD and confirmed cost drivers of BD/BD-I. Improved clinical management of BD/BD-I and associated comorbidities, together with better medication adherence, may reduce health-care costs and improve patient outcomes.

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Section: Resultsmentioning

confidence: 99%

“… 63 – 65 Moreover, an increased number of lifetime mood episodes was associated with higher likelihood of permanent disability and unemployment. 64 …”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 95%

See 2 more Smart Citations

<p>The Economic Burden of Bipolar Disorder in the United States: A Systematic Literature Review</p>

Bessonova

Ogden

Doane

et al. 2020

CEOR

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“… 3 – 5) The frequent recurrences of bipolar disorders are associated with poorer functioning, psychiatric and medical comorbidities, and increased odds of suicidality, disability, unemployment, and re-hospitalization. 6) …”

Section: Introductionmentioning

confidence: 99%

Predictors of a Shorter Time to Hospitalization in Patients with Bipolar Disorder: Medication during the Acute and Maintenance Phases and Other Clinical Factors

Shim

Woo

Wang

et al. 2017

Clin Psychopharmacol Neurosci

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ObjectiveThe present study was conducted to compare the effects of pharmacological treatments during the acute and maintenance phases of mood episodes, sociodemographic, and clinical characteristics between a shorter time to hospitalization group (<12 months) and a longer time to hospitalization group (≥12 months).MethodsThe discharge medication for the first hospitalization was considered the acute treatment and the medication used during the week prior to the second hospitalization at the outpatient clinic was considered the maintenance treatment. Additionally, the charts were reviewed to examine a variety of demographic and clinical characteristics.ResultsPatients in the shorter time to hospitalization group were more likely to be unmarried and/or unemployed, have had a previous hospital admission for a mood episode, and have used antidepressant during the acute phase than those in the longer time to hospitalization group. Patients in the shorter time to hospitalization group were also less likely to use olanzapine, serotonin-norepinephrine reuptake inhibitors, or mood stabilizer monotherapy as a maintenance treatment than were patients in the longer time to hospitalization group.ConclusionPredictors for shorter time to hospitalization were associated with number of previous hospital admissions for a mood episode, being unmarried and/or unemployed, and antidepressant use during the acute phase.

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Composite immune marker scores associated with severe mental disorders and illness course

Ormerod¹,

Ueland²,

Werner³

et al. 2022

Brain, Behavior, & Immunity - Health

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The Burden of Repeated Mood Episodes in Bipolar I Disorder

Cited by 40 publications

References 34 publications

<p>The Economic Burden of Bipolar Disorder in the United States: A Systematic Literature Review</p>

<p>The Economic Burden of Bipolar Disorder in the United States: A Systematic Literature Review</p>

Predictors of a Shorter Time to Hospitalization in Patients with Bipolar Disorder: Medication during the Acute and Maintenance Phases and Other Clinical Factors

Composite immune marker scores associated with severe mental disorders and illness course

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