The burden of SARS-CoV-2 among healthcare workers across 16 hospitals of Kashmir, India—A seroepidemiological study

Haq, Inaamul; Qurieshi, Mariya Amin; Khan, Muhammad Salim; Majid, Sabhiya; Bhat, Arif Akbar; Kousar, Rafiya; Chowdri, Iqra Nisar; Qazi, Tanzeela Bashir; Lone, Abdul Aziz; Sabah, Iram; Kawoosa, Misbah Ferooz; Nabi, Syed Ashfaq; Sumji, Ishtiyaq Ahmad; Ayoub, Shifana; Khan, Mohammad Ashraf; Anjum, Asma; Ismail, Shaista

doi:10.1371/journal.pone.0259893

Cited by 3 publications

(2 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, the seropositivity to SARS-CoV-2 may noticeably fluctuate depending on different parameters such as geographical location and the time when the research was conducted (stage of the pandemic), timeliness and the enforcement of infection control measures, the sampling strategies and type of serological test used, and may progressively increase over time. Therefore, it is not surprising that in our study, which was conducted later during the pandemic, after the sixth epidemic wave of COVID-19 and more than one year since the beginning of the vaccination campaigns in Serbia and elsewhere, the observed prevalence was much higher compared to the prevalence rates obtained in various populations of HCWs in several other SARS-CoV-2 seroprevalence studies that were performed before the period of our research [2,[16][17][18][19][20][21][22][23][24][25]. In addition, numerous previous studies reported that the seroprevalence to SARS-CoV-2 among HCWs was higher in comparison with the general population [4,17,26,27].…”

Section: Discussionmentioning

confidence: 51%

Seroepidemiology of SARS-CoV-2 Virus in Healthcare Workers before Circulation of the Omicron Sublineages BA.4/BA.5 in Vojvodina, Serbia

et al. 2022

View full text Add to dashboard Cite

Healthcare workers (HCWs) are a vulnerable and critical population in the ongoing response to the SARS-CoV-2 pandemic. We aimed to estimate the seroprevalence in HCWs considering all of their previous contacts with the SARS-CoV-2 virus and/or the immunity acquired through their immunization against COVID-19 before the advent of the Omicron variants BA.4/BA.5. Serum samples were collected from 28 March to 10 June 2022. We covered 25% out of all the people who worked in some of the government healthcare centers (primary, secondary, and tertiary level) across the entire Autonomous Province of Vojvodina (Northern Serbia). Two serological tests (Anti-SARS-CoV-2 QuantiVac ELISA and LIAISON® SARS-CoV-2 TrimericS) were used to detect anti-spike IgG antibodies. The overall prevalence of the SARS-CoV-2 antibody among the 6936 HCWs was 92.96% [95% CI 92.33–93.55]. Regarding the type of serological test, there was a statistically significant (p = 0.0079) difference of the seropositivity obtained by the LIAISON® SARS-CoV-2 TrimericS (93.87%, 95% CI 92.97–94.69) and Anti-SARS-CoV-2 QuantiVac ELISA (92.23%, 95% CI 91.34–93.06) tests. Seropositivity to SARS-CoV-2 significantly (p < 0.0001) increased with the number of SARS-CoV-2 infections combined with the number of doses of the SARS-CoV-2 vaccines received. A vast majority of the HCWs in Vojvodina had detectable levels of antibodies to the spike protein of SARS-CoV-2, but despite this high seropositivity, it is unknown whether this herd immunity among HCWs is protective against the new variants of concern. Further research should evaluate the rates of reinfections and the associated severity of COVID-19 caused by the Omicron sublineages and/or new variants of SARS-CoV-2 among HCWs.

show abstract

Section: Discussionmentioning

confidence: 51%

Seroepidemiology of SARS-CoV-2 Virus in Healthcare Workers before Circulation of the Omicron Sublineages BA.4/BA.5 in Vojvodina, Serbia

et al. 2022

View full text Add to dashboard Cite

show abstract

“…All vaccines follow the same basic principle, pre-exposing the immune system of a person to either killed or weakened pathogens, or some of the pathogen's structural parts, which leads the body to elicit an immune response (9). Similar to infection, vaccines result in early production of serum immunoglobulin (Ig)A, IgM and IgG antibodies, and also induce long-lasting memory B-and T-cell responses (10)(11)(12). Adenoviral vaccines are those in which viral gene delivery systems rely on a host viral genome (e.g., adenovirus) that typically lacks the genetic components necessary to produce new virions and that encodes antigenic components of the virus of interest to elicit a protective immune response, primarily through virus-neutralizing antibodies specific for spike protein of SARS-CoV-2.…”

Section: Introductionmentioning

confidence: 99%

Impact of clinico-biochemical and inflammatory biomarkers on the immunogenicity and efficacy of SARS-CoV-2 adenoviral vaccine: a longitudinal study

Majid,

Khan,

Nisar

et al. 2023

J Circ Biomark

Self Cite

View full text Add to dashboard Cite

Purpose: Due to a lack of effective antiviral treatment, several vaccines have been put forth to curb SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection and to reduce the mortality and morbidity rate by eliciting a protective immune response, primarily through virus-neutralizing antibodies specific for SARS-CoV-2 spike protein. This longitudinal study was designed to evaluate the vaccine effectiveness and immune response following the administration of adenoviral vaccine, COVISHIELD, in Indian population who were previously uninfected with SARS-CoV-2 and to reveal the effect of various sociodemographic, inflammatory and biochemical factors on antibody response. Methods: Briefly, the total immunoglobulin G (IgG) against SARS-CoV-2 spike and nucleocapsid protein along with the immunological markers were estimated by chemiluminescent microparticle immunoassay (CMIA) technology. Biochemical parameters were estimated by spectrometry. Results: A total of 348 subjects received two doses of COVISHIELD (224 males, 124 females). The mean age of the study subjects was 42.03 ± 13.54 years. Although both the doses of COVISHIELD against SARS-CoV-2 spike protein induced a robust immune response that lasted for months in all the subjects, the total IgG titer against SARS-CoV-2 spike protein was found significantly higher in subjects ≥50 years of age, and those with obesity, elevated triglycerides and elevated lactate dehydrogenase levels. Conclusions: There is a definite effect of age and biochemical factors on the immunogenicity of COVISHIELD. An understanding of these factors could not only impact the design of vaccines and help improve vaccine immunogenicity and efficacy but also assist in decisions on vaccination schedules, in order to combat this deadly pandemic.

show abstract

A multi-site cross-sectional study on the burden of SARS-CoV-2 in healthcare workers in Madagascar

Abrokwa,

Ravaoarisoa,

Briesemeister

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

The prevalence of infections and risk factors that go along with them give insights into the burden of disease and effectiveness of infection prevention and control strategies. In this study we investigated the burden of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and associated epidemiological factors in three regions of Madagascar among healthcare workers. Between May and June 2021, we conducted a multi-site cross-sectional study among healthcare workers in eight University Hospital Centers, during the local second wave and before the coronavirus disease 2019 vaccination campaign in three regional capitals of Madagascar. We collected demographic information and relevant SARS-CoV-2 exposure history and tested for both immunoglobulin G antibodies to SARS-CoV-2 spike protein, using enzyme-linked immunosorbent assay and active SARS-CoV-2 infection using real-time reverse transcription-polymerase chain reaction. A total of 1006 healthcare workers enrolled in the study out of which 53.8% tested positive for either acute infection or SARS-CoV-2 antibodies. Approximately 50% of the participants reported receiving inadequate training on SARS-CoV-2 and associated infection prevention and control measures, inadequate supply of Personal Protective Equipment (PPE) and discomfort when using available PPE. Prevalence of acute infection was 3.4% without statistically significant variation in the different regions or health facilities as well as the different profession groups and units of work. Average seroprevalence of SARS-CoV-2 IgG antibodies was 52.0%, varying between 47.8% and 53.3% across the different regions. No significant difference was observed for region, gender, profession, and different risk groups. Predictive multivariable model showed significant association between seropositivity and healthcare facility and age (p<0.05). Our results revealed high infection rate of SARS-CoV-2 in HCWs in all three selected regions of Madagascar. The high disease burden identified in the study population might characterize the extent of high undocumented infection rates in HCWs in other regions of Madagascar.

show abstract

The burden of SARS-CoV-2 among healthcare workers across 16 hospitals of Kashmir, India—A seroepidemiological study

Cited by 3 publications

References 19 publications

Seroepidemiology of SARS-CoV-2 Virus in Healthcare Workers before Circulation of the Omicron Sublineages BA.4/BA.5 in Vojvodina, Serbia

Seroepidemiology of SARS-CoV-2 Virus in Healthcare Workers before Circulation of the Omicron Sublineages BA.4/BA.5 in Vojvodina, Serbia

Impact of clinico-biochemical and inflammatory biomarkers on the immunogenicity and efficacy of SARS-CoV-2 adenoviral vaccine: a longitudinal study

A multi-site cross-sectional study on the burden of SARS-CoV-2 in healthcare workers in Madagascar

Contact Info

Product

Resources

About