The burden of <scp>Helicobacter pylori</scp> infection in Europe

O'Connor, H.J.; Sebastian, Shaji

doi:10.1046/j.0953-0673.2003.01726.x

Cited by 15 publications

(11 citation statements)

References 52 publications

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“…Strong birth‐cohort phenomenon in H. pylori infection (from the time of the end of the Second World War) has been found in developed countries [65–71]. Given the cross‐sectional nature of our study where all age groups were investigated at the same point in time, we cannot formally investigate birth‐cohort effects on H. pylori infection in our study.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of Helicobacter pylori Infection in the Czech Republic

et al. 2006

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This is a unique study based on a representative sample of the general population in a Central European country. The overall prevalence of H. pylori is lower than previously assumed and could partly reflect a substantial recent decrease in H. pylori prevalence in the Czech Republic. Consistent with earlier studies, H. pylori infection is strongly influenced by socioeconomic conditions and childhood poverty.

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Section: Discussionmentioning

confidence: 99%

Epidemiology of Helicobacter pylori Infection in the Czech Republic

et al. 2006

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“…Only five studies were found to examine the subject in any significant detail, 512 651-654 and even in these varied in the topics and diseases covered. Among those included in this review, are the prevention of H pylori, 654 traveller's diarrhoea, 653 and NSAID related morbidity and mortality. 512 Muller and Sonnenberg emphasise the beneficial effects of endoscopy for reducing mortality due to colorectal cancer and cancers of the large bowel, and outline its crucial role as a preventative procedure.…”

Section: Preventionmentioning

confidence: 99%

Gastroenterology services in the UK. The burden of disease, and the organisation and delivery of services for gastrointestinal and liver disorders: a review of the evidence

Roberts

Ali

Cheung

et al. 2007

Gut

137

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“…Helicobator pylori is linked causally to gastric cancer and we know that the production of reactive oxygen species (ROS) is one way that the bacterium exerts its effect on gastric cells (Correa, 1988;Asaka et al, 1997;Chan et al, 1999;Obst et al, 2000). Indeed, O'Connor and Sebastian (2003) suggested that H. pylori infection may account for 60% of all gastric cancers worldwide. There is now a large body of evidence linking H. pylori to gastric cancer with epidemiological studies showing a 3 -12-fold increased risk of gastric cancer in those people infected with H. pylori (Cover and Blaser, 1995).…”

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confidence: 99%

Fluorescence in situ hybridisation analysis of chromosomal aberrations in gastric tissue: the potential involvement of Helicobacter pylori

et al. 2005

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In this series of experiments, a novel protocol was developed whereby gastric cells were collected using endoscopic cytology brush techniques, and prepared, such that interphase fluorescence in situ hybridization (FISH) could be performed. In total, 80 distinct histological samples from 37 patients were studied using four chromosome probes (over 32 000 cells analysed). Studies have previously identified abnormalities of these four chromosomes in upper GI tumours. Using premalignant tissues, we aimed to determine how early in Correa's pathway to gastric cancer these chromosome abnormalities occurred. Aneuploidy of chromosomes 4, 8, 20 and 17(p53) was detected in histologically normal gastric mucosa, as well as in gastritis, intestinal metaplasia, dysplasia and cancer samples. The levels of aneuploidy increased as disease severity increased. Amplification of chromosome 4 and chromosome 20, and deletion of chromosome 17(p53) were the more common findings. Hence, a role for these abnormalities may exist in the initiation of, and the progression to, gastric cancer. Helicobactor pylori infection was determined in premalignant tissue using histological analysis and PCR technology. Detection rates were comparable. PCR was used to subtype H. pylori for CagA status. The amplification of chromosome 4 in gastric tissue was significantly more prevalent in H. pylori-positive patients (n ¼ 7) compared to H. pylori-negative patients (n ¼ 11), possibly reflecting a role for chromosome 4 amplification in H. pylori-induced gastric cancer. The more virulent CagA strain of H. pylori was associated with increased disease pathology and chromosomal abnormalities, although numbers were small (CagA þ n ¼ 3, CagAÀ n ¼ 4). Finally, in vitro work demonstrated that the aneuploidy induced in a human cell line after exposure to the reactive oxygen species (ROS) hydrogen peroxide was similar to that already shown in the gastric cancer pathway, and may further strengthen the hypothesis that H. pylori causes gastric cancer progression via an ROS-mediated mechanism.

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The burden of Helicobacter pylori infection in Europe

Cited by 15 publications

References 52 publications

Epidemiology of Helicobacter pylori Infection in the Czech Republic

Epidemiology of Helicobacter pylori Infection in the Czech Republic

Gastroenterology services in the UK. The burden of disease, and the organisation and delivery of services for gastrointestinal and liver disorders: a review of the evidence

Fluorescence in situ hybridisation analysis of chromosomal aberrations in gastric tissue: the potential involvement of Helicobacter pylori

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