The Burden of Single Virus and Viral Coinfections on Severe Lower Respiratory Tract Infections Among Preterm Infants

Arruda, Eurico; Jones, Marcus Herbert; Paula, Flávia Escremim de; Chong, Débora C; Bugarin, Gabriela; Notario, Gerard; Matsuno, Alessandra Kimie; Pitrez, Paulo Márcio; Vo, Pamela; Suzuki, Claudia Eiko; Filho, Nelson Rosário; Stein, Renato T.

doi:10.1097/inf.0000000000000349

Cited by 33 publications

(41 citation statements)

References 53 publications

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“…Thirty‐four studies from 26 countries that were published between 2002 and 2014, with RSV‐associated ARI hospitalization rates for community‐acquired, medically attended, laboratory‐confirmed severe RSV‐ARI in children <5 years of age, were included in the incidence analysis. The incidence estimates of RSV‐associated ARI hospitalization (per 1,000 children per year) were stratified according to age and region (Table ).…”

Section: Resultsmentioning

confidence: 99%

Respiratory syncytial virus hospitalization and mortality: Systematic review and meta‐analysis

Stein

Bont

Zar

et al. 2016

Pediatric Pulmonology

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267

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SummaryBackground: Respiratory syncytial virus (RSV) is a major public health burden worldwide. We aimed to review the current literature on the incidence and mortality of severe RSV in children globally. Methods: Systematic literature review and meta‐analysis of published data from 2000 onwards, reporting on burden of acute respiratory infection (ARI) due to RSV in children. Main outcomes were hospitalization for severe RSV‐ARI and death. Results: Five thousand two hundred and seventy‐four references were identified. Fifty‐five studies were included from 32 countries. The global RSV‐ARI hospitalization estimates, reported per 1,000 children per year (95% Credible Interval (CrI), were 4.37 (2.98, 6.42) among children <5 years, 19.19 (15.04, 24.48) among children <1 year, 20.01 (9.65, 41.31) among children <6 months and 63.85 (37.52, 109.70) among premature children <1 year. The RSV‐ARI global case‐fatality estimates, reported per 1,000 children, (95% Crl) were 6.21 (2.64, 13.73) among children <5 years, 6.60 (1.85, 16.93) for children <1 year, and 1.04 (0.17, 12.06) among preterm children <1 year. Conclusions: A substantial proportion of RSV‐associated morbidity occurs in the first year of life, especially in children born prematurely. These data affirm the importance of RSV disease in the causation of hospitalization and as a significant contributor to pediatric mortality and further demonstrate gestational age as a critical determinant of disease severity. An important limitation of case‐fatality ratios is the absence of individual patient characteristics of non‐surviving patients. Moreover, case‐fatality ratios cannot be translated to population‐based mortality. Pediatr Pulmonol. 2017;52:556–569. © 2016 The Authors. Pediatric Pulmonology. Published by Wiley Periodicals, Inc.

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Section: Resultsmentioning

confidence: 99%

Respiratory syncytial virus hospitalization and mortality: Systematic review and meta‐analysis

Stein

Bont

Zar

et al. 2016

Pediatric Pulmonology

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267

206

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“…Some studies carried out in the United States show lower hospitalization rates in preterm infants than those reported in previous analyses . Also, the incidence of RSV‐associated hospitalization varies in studies carried out in different countries . In a systematic review that assessed the incidence of RSV hospitalization in healthy preterm infants 29‐35 weeks of age, a wide variation of in hospitalization rates (2.3%‐10%) was observed .…”

Section: Discussionmentioning

confidence: 99%

Respiratory syncytial virus acute respiratory infection‐associated hospitalizations in preterm Mexican infants: A cohort study

Benítez‐Guerra

Piña‐Flores

Zamora‐López

et al. 2020

Influenza Resp Viruses

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Background Respiratory syncytial virus (RSV) is the leading cause of severe acute respiratory infections (ARI) in preterm infants. The incidence of RSV‐associated hospitalizations has not been defined in Mexico. Objectives To determine the incidence of ARI‐ and RSV‐associated hospitalizations in preterm infants during the first year of life. Methods Prospective cohort study of 294 preterm infants followed up through monthly telephone calls and routine outpatient visits. Hospitalized children were identified through daily visits to pediatric wards of participating hospitals and through telephone calls. Respiratory samples were tested for RSV by RT‐PCR. Results Mean gestational age of participating infants was 33 weeks. Ninety‐six infants were diagnosed with bronchopulmonary dysplasia (BPD) and 17 with congenital heart disease (CHD); 11 had both conditions. There were 71 hospitalization episodes in 53 infants. Respiratory samples for RSV detection were available in 44 hospitalization episodes, and the result was positive in 16 (36.3%). At least one hospitalization for ARI was recorded in 33 of 96 participants with BPD, in seven of 17 with CHD, and 18 of 192 infants without these diagnoses. Five (71.4%) of CHD infants who required admission also had BPD. RSV‐confirmed hospitalization rates were 9.4%, 5.9%, and 2.6% for infants with BPD, CHD, and otherwise healthy preterm infants, respectively. Attributable RSV admission frequencies were estimated to be 13.6%, 16.5%, and 4.1%, respectively. Conclusions Mexican preterm infants, particularly those with BPD, have high rates of ARI‐ and RSVassociated hospitalizations. Specific interventions to reduce the incidence of severe infections in this highrisk group are required.

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“…Table 1 summarizes the characteristics of the studies included in the main analysis, such as age, prevalence of coinfection, setting of enrollment, viruses tested through molecular biology techniques, specific combinations of viruses compared and outcomes assessed. Forty-three studies with 17234 patients were included [6,[8][9][10][12][13][14][15][16][17][18][19]21,. Final analyses included the following outcomes: length of stay (24 studies, 3548 patients), need of hospitalization (11 studies, 9637 patients), need of supplemental oxygen (12 studies, 2285 patients) and length of supplemental oxygen (5 Table 2 Summary of findings and quality of evidence for severity of viral coinfections versus single infections in children.…”

Section: Study Selectionmentioning

confidence: 99%

“…The relationship between detection of multiple respiratory viral infections and severity of disease in children has not been well established. Several studies have reported longer length of stay in hospital, an increased risk of hospitalizations, of admission to pediatric intensive care unit (PICU), of need for mechanical ventilation and even higher mortality, when two or more respiratory viruses were detected [11][12][13][14][15][16][17].…”

mentioning

confidence: 99%

Respiratory viral coinfection and disease severity in children: A systematic review and meta-analysis

Scottá

Chakr

Moura

et al. 2016

Journal of Clinical Virology

112

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The Burden of Single Virus and Viral Coinfections on Severe Lower Respiratory Tract Infections Among Preterm Infants

Abstract: This study confirms the association of RSV alone or as a coinfection with severe LRTI and reinforces the importance of providing adequate prophylaxis for susceptible infants.

Cited by 33 publications

References 53 publications

Respiratory syncytial virus hospitalization and mortality: Systematic review and meta‐analysis

Respiratory syncytial virus hospitalization and mortality: Systematic review and meta‐analysis

Respiratory syncytial virus acute respiratory infection‐associated hospitalizations in preterm Mexican infants: A cohort study

Respiratory viral coinfection and disease severity in children: A systematic review and meta-analysis

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