The butanol fraction of Eclipta prostrata (Linn) increases the formation of brain acetylcholine and decreases oxidative stress in the brain and serum of cesarean-derived rats

Kim, Daeik; Lee, Sung-Hyen; Hong, Joo-Heon; Lillehoj, Hyun S.; Park, Hong-Ju; Rhie, Seung-Gyo; Lee, Gun-Soon

doi:10.1016/j.nutres.2010.08.001

Cited by 25 publications

(19 citation statements)

References 42 publications

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“…These results indicate that RGO application will enhance stem cell viability and improve their effects in cell therapy (13). Butanol extracted from Eclipta prostrata (Linn) has been demonstrated to produce an anti-oxidative effect in cesarean-derived rats, and saponin is a primary ingredient in butanol extract, which has been observed to result in in-vitro anti-oxidative effects (14). Further study is required to determine whether these effects are associated with the effect of BT on improving AGA.…”

Section: Discussionmentioning

confidence: 99%

Hair growth is promoted by BeauTop via expression of EGF and FGF‑7

Lee

Yang

Lin³

et al. 2018

Mol Med Report

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Minoxidil and finasteride have been approved to treat hair loss by the Food and Drug Administration. However, the further elucidation of treatments for hair loss, including those using Chinese herbal medicine, remains important clinically. BeauTop (BT) is a health food supplement which contains Ginseng radix, Astragali radix, Radix Angelicae sinensis, Ligustri fructus, Rehmannia glutinosa and Eclipta prostrata (Linn). Susbsequent to oral administration of BT at 0.6 g/kg/day to wax/rosin-induced alopecia in C57BL/6 mice, BT significantly induced hair growth at day 8 compared with control treatment (P<0.05). The expression levels of epidermal growth factor (EGF), and fibroblast growth factor (FGF)-7 were increased compared with control animals on day 8. In contrast, levels of FGF-5 of the BT group were reduced compared with the control on day 12. There were no effects on the expression of insulin-like growth factor 1. The results demonstrated that the mechanism of BT improving alopecia is potentially associated with modulation of EGF and FGF-7 levels. Taken together, it is suggested that BT may have a potential effect of the promotion of hair growth.

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Section: Discussionmentioning

confidence: 99%

Hair growth is promoted by BeauTop via expression of EGF and FGF‑7

Lee

Yang

Lin³

et al. 2018

Mol Med Report

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“…Previously, it had been reported that the long-term administration of the butanolic fraction of E. prostrata increases the formation of brain acetylcholine (Kim et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

“…Thus, E. prostrata has been used for whole body nourishment and nervine tonic in Asia. Recently, it has been also reported that the chronic administration of E. prostrata increases the formation of acetylcholine in the brain (Kim et al, 2010). Based on traditional knowledge and recent findings by Kim et al, we hypothesized that E. prostrata would improve cognitive function and be useful for the treatment against dementia.…”

Section: Introductionmentioning

confidence: 89%

The ethanolic extract of the Eclipta prostrata L. ameliorates the cognitive impairment in mice induced by scopolamine

Jung

Kim

Park

et al. 2016

Journal of Ethnopharmacology

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“…Flavonoids act in this plant as natural antioxidants 19 . Previous studies revealed that a butanol fraction of the whole plant could increase the level of acetylcholine and attenuate oxidative stress in the brain and serum of rats, suggesting its use to prevent memory impairment 20 . A hydroalcoholic extract obtained from the aerial parts markedly ameliorates ischaemiainduced neuronal loss of the rat brain 21 .…”

Section: Introductionmentioning

confidence: 99%

Protective effects of ethyl acetate extract of Eclipta prostrata against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells

Jaisin¹,

Ratanachamnong²,

Prachayasittikul³

et al. 2016

ScienceAsia

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ABSTRACT:Oxidative stress plays an important role in the pathogenesis of Parkinson's disease. The neurotoxin 6-hydroxydopamine initiates cellular oxidative stress which has been implicated in neurodegenerative conditions related to Parkinson's disease. Eclipta prostrata, also known as false daisy, is a plant belonging to the sunflower family. It is a rich source of phenolic compounds that confer the plant an antioxidant activity. In this study, we investigated the protective effects of ethyl acetate extract of E. prostrata against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells. Pretreatment with the ethyl acetate extract of E. prostrata before exposing the cells to 6-hydroxydopamine significantly increased cell survival and reduced intracellular reactive oxygen species formation in a concentrationdependent manner. In addition, the ethyl acetate extract of E. prostrata suppressed the Bax/Bcl-2 ratio and reduced caspase-3 activity, a key modulator of cell apoptosis. Our finding clearly shows that the ethyl acetate extract of E. prostrata possesses a potential antioxidant capacity and attenuates SH-SY5Y cell death by blocking apoptotic signalling caused by 6-hydroxydopamine. E. prostrata could therefore be used as a potential herb to prevent oxidative stress-induced neurodegeneration in Parkinson's disease.

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The butanol fraction of Eclipta prostrata (Linn) increases the formation of brain acetylcholine and decreases oxidative stress in the brain and serum of cesarean-derived rats

Cited by 25 publications

References 42 publications

Hair growth is promoted by BeauTop via expression of EGF and FGF‑7

Hair growth is promoted by BeauTop via expression of EGF and FGF‑7

The ethanolic extract of the Eclipta prostrata L. ameliorates the cognitive impairment in mice induced by scopolamine

Protective effects of ethyl acetate extract of Eclipta prostrata against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells

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