The Ca2+-Binding S100B Protein: An Important Diagnostic and Prognostic Neurobiomarker in Pediatric Laboratory Medicine

Gazzolo, Diego; Pluchinotta, Francesca Romana; Lapergola, Giuseppe; Franchini, Simone

doi:10.1007/978-1-4939-9030-6_44

Cited by 9 publications

(7 citation statements)

References 149 publications

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“…This finding is also corroborated by increased CSOR ratio values (>1), as expression of a hemodynamic redistribution from the splanchnic to the brain region. Another explanation may lie in the delivery of extra blood volume by the liver, as occurs in other intrauterine conditions such as growth retardation [20,28]. Altogether, it is possible to argue that OMT may reasonably be responsible for a redistribution from the splanchnic to the brain region followed by a significantly improved splanchnic oximetry and function in the presence of a stable increased CNS oximetry and tissue activation levels.…”

Section: Discussionmentioning

confidence: 99%

Osteopathic Manipulation Treatment Improves Cerebro–splanchnic Oximetry in Late Preterm Infants

Marinelli¹,

Pluchinotta

Cozzolino³

et al. 2019

Molecules

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Background: To evaluate the effectiveness/side-effects of osteopathic manipulation treatment (OMT) performed on the 7th post-natal day, on cerebro–splanchnic oximetry, tissue activation and hemodynamic redistribution in late preterm (LP) infants by using near infrared spectroscopy (NIRS). Methods: Observational pretest-test study consisting in a cohort of 18 LPs who received OMT on the 7th post-natal day. NIRS monitoring was performed at three different time-points: 30 min before (T0), (30 min during (T1) and 30 min after OMT (T2). We evaluated the effects of OMT on the following NIRS parameters: cerebral (c), splanchnic (s) regional oximetry (rSO2), cerebro–splanchnic fractional tissue oxygen extraction (FTOE) and hemodynamic redistribution (CSOR). Results: crSO2 and cFTOE significantly (P < 0.001) improved at T0-T2; srSO2 significantly (P < 0.001) decreased and sFTOE increased at T0-T1. Furthermore, srSO2 and sFTOE significantly improved at T1-T2. Finally, CSOR significantly (P < 0.05) increased at T0-T2. Conclusions: The present data show that OMT enhances cerebro–splanchnic oximetry, tissue activation and hemodynamic redistribution in the absence of any adverse clinical or laboratory pattern. The results indicate the usefulness of further randomized studies in wider populations comparing the effectiveness of OMT with standard rehabilitation programs.

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Section: Discussionmentioning

confidence: 99%

Osteopathic Manipulation Treatment Improves Cerebro–splanchnic Oximetry in Late Preterm Infants

Marinelli¹,

Pluchinotta

Cozzolino³

et al. 2019

Molecules

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“…Some researchers have described S100B as "the C-reactive protein (CRP) of the brain." [12] and suggested its use in monitoring fetal distress and other highrisk fetuses [13]. In 2012, Cai et al [14], reported that the S100B expression in women with early-onset preeclampsia was significantly higher than that in the control group and in late-onset preeclampsia group, indicating that S100B may be a risk factor in early-onset preeclampsia.…”

Section: Introductionmentioning

confidence: 99%

Clinical significance of S100B protein in pregnant woman with early- onset severe preeclampsia

Sheng

Zhou

et al. 2024

Ginekol Pol

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“…Several reports demonstrated that S100B is a valuable biomarker of brain damage among high‐risk fetuses and newborns 15–17 . Cord blood S100B level has the highest sensitivity for predicting preterm brain injury 18 .…”

Section: Introductionmentioning

confidence: 99%

“…13 Several reports demonstrated that S100B is a valuable biomarker of brain damage among high-risk fetuses and newborns. [15][16][17] Cord blood S100B level has the highest sensitivity for predicting preterm brain injury. 18 A recent metaanalysis showed that S100B levels in the first 24 h of life predict neurological outcomes in patients with perinatal asphyxia.…”

Section: Introductionmentioning

confidence: 99%

Antenatal corticosteroids‐to‐delivery interval associates cord blood S100B levels

Fuma

Kotani

Ushida

et al. 2023

J of Obstet and Gynaecol

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Aim: Antenatal corticosteroids (ACS) are recommended for women at risk of preterm birth before 34 weeks' gestation. However, adverse effects of ACS on the fetal brain have also been reported. The time interval from ACS administration to delivery (ACS-to-delivery interval) might alter the effect of ACS on the fetal brain. This study aimed to evaluate the effect of ACS-to-delivery interval on cord blood S100 calcium-binding protein B (S100B) levels as a biomarker of brain damage. Methods: Women who delivered between 2012 and 2020 at a tertiary medical center were divided into three groups according to ACS use and ACS-to-delivery interval, retrospectively: non-ACS, ACS ≤7 days, and ACS >7 days. Patients who did not complete the ACS regimen were excluded. The primary outcome was cord blood S100B levels. Results: Cord blood S100B levels were significantly lower in the ACS ≤7 days group than in the non-ACS and ACS >7 days groups. In the multiple regression analysis, birth ≤7 days after ACS showed a significant negative association with S100B level (p < 0.001). Conclusions: Reduced S100B levels were observed in infants born ≤7 days after ACS but not in infants born >7 days after ACS. These findings suggest the importance of ACS timing to optimize its effects on the fetal brain, although further studies are required to identify these mechanisms.

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The Ca2+-Binding S100B Protein: An Important Diagnostic and Prognostic Neurobiomarker in Pediatric Laboratory Medicine

Cited by 9 publications

References 149 publications

Osteopathic Manipulation Treatment Improves Cerebro–splanchnic Oximetry in Late Preterm Infants

Osteopathic Manipulation Treatment Improves Cerebro–splanchnic Oximetry in Late Preterm Infants

Clinical significance of S100B protein in pregnant woman with early- onset severe preeclampsia

Antenatal corticosteroids‐to‐delivery interval associates cord blood S100B levels

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