The calcium channel blocker used with cyclosporin has an effect on gingival overgrowth

James, J A; Marley, John; Jamal, Sundos; Campbell, Babatunde; Short, Colin D.; Johnson, Raymond F.; Hull, Peter; Spratt, Heidi; Irwin, Christopher; Boomer, S.; Maxwell, Alexander P.; Linden, Gerard J.

doi:10.1034/j.1600-051x.2000.027002109.x

Cited by 37 publications

(44 citation statements)

References 24 publications

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“…The differences in these investigations depend in part on culture conditions (James et al, 1998(James et al, , 2000. While cyclosporin A was found to increase glycosaminoglycan secretion by fibroblasts (Newell and Irwin, 1997), and nifedipine and phenytoin increased heparan levels (Saito et al, 1996), other studies failed to report any differences in vivo (Romanos et al, 1992(Romanos et al, , 1993Rocha et al, 2000;Martins et al, 2003).…”

Section: Direct Effects Of Phenytoin Cyclosporin and Nifedipine On mentioning

confidence: 92%

Connective Tissue Metabolism and Gingival Overgrowth

Trackman

Kantarcı

2004

Critical Reviews in Oral Biology & Medicine

136

152

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Gingival overgrowth occurs mainly as a result of certain anti-seizure, immunosuppressive, or antihypertensive drug therapies. Excess gingival tissues impede oral function and are disfiguring. Effective oral hygiene is compromised in the presence of gingival overgrowth, and it is now recognized that this may have negative implications for the systemic health of affected patients. Recent studies indicate that cytokine balances are abnormal in drug-induced forms of gingival overgrowth. Data supporting molecular and cellular characteristics that distinguish different forms of gingival overgrowth are summarized, and aspects of gingival fibroblast extracellular matrix metabolism that are unique to gingival tissues and cells are reviewed. Abnormal cytokine balances derived principally from lymphocytes and macrophages, and unique aspects of gingival extracellular matrix metabolism, are elements of a working model presented to facilitate our gaining a better understanding of mechanisms and of the tissue specificity of gingival overgrowth.

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Section: Direct Effects Of Phenytoin Cyclosporin and Nifedipine On mentioning

confidence: 92%

Connective Tissue Metabolism and Gingival Overgrowth

Trackman

Kantarcı

2004

Critical Reviews in Oral Biology & Medicine

136

152

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“…In 57.3%, cyclosporine A was administered in combination with calcium channel blockers. Higher prevalence of gingival hyperplasia was observed in the combina-binaciji ciklosporina A s amlodipinom, negoli u kombinaciji CSA s nifedipinom (28).…”

Section: Gašpar I Surmentioning

confidence: 97%

“…Naši rezultati pokazali su da je samo 48 posto naših pacijenata bilo kod tion of drugs cyclosporine A with amlodipine than in nifedipine with cyclosporine A (28).…”

Section: Gašpar I Surunclassified

The Oral Cavity State in Renal Transplant Recipients

Gašpar¹,

Glavina²,

Grubišić³

et al. 2015

Acta Stomatol Croat

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“…Patients undergoing monotherapy with amlodipine had less gingival overgrowth than those taking nifedipine. 8 A cohort study of 135 renal-transplantation patients demonstrated that the combined use of cyclosporine and nifedipine caused less gingival overgrowth (53%) than that in patients treated with cyclosporine and amlodipine (72%). 8 Many studies showed that the combined use of CCBs and immunosuppressants enhanced the risk and severity of gingival overgrowth.…”

Section: Discussionmentioning

confidence: 98%

Phenytoin- and amlodipine-induced gingival overgrowth

Chang

Yang

Lai

2012

Journal of Dental Sciences

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Drug-induced gingival overgrowth is an adverse event associated with three types of drugs, i.e., anticonvulsants, immunosuppressants, and calcium-channel blockers. It was shown that the combined use of an immunosuppressant (cyclosporine) and a calciumchannel blocker increases the prevalence and severity of gingival overgrowth. However, few reports discussed the effects of the combination of an anticonvulsant (phenytoin) and a calcium-channel blocker (amlodipine). In this case report, we present an epilepsy patient who was using both phenytoin and amlodipine, which caused extensive gingival overgrowth. After periodontal treatment and a gingivectomy, the gingival overgrowth was significantly reduced. A postoperative drug-substitution regimen and intensive professional care ensured a stable result 1 year after surgery.

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The calcium channel blocker used with cyclosporin has an effect on gingival overgrowth

Abstract: The prevalence of gingival overgrowth in renal transplant recipients maintained on cyclosporin A and nifedipine is lower than those treated with cyclosporin A and amlodipine.

Cited by 37 publications

References 24 publications

Connective Tissue Metabolism and Gingival Overgrowth

Connective Tissue Metabolism and Gingival Overgrowth

The Oral Cavity State in Renal Transplant Recipients

Phenytoin- and amlodipine-induced gingival overgrowth

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