The cameroon mobile phone sms (CAMPS) trial: a protocol for a randomized controlled trial of mobile phone text messaging versus usual care for improving adherence to highly active anti-retroviral therapy

Mbuagbaw, Lawrence; Thabane, L.; Ongolo‐Zogo, Pierre; Lester, Richard; Mills, Edward J.; Volmink, Jimmy; Yondo, David; Essi, Marie José; Bonono-Momnougui, Renee-Cecile; Thomas, Robert; Ndongo, Jean Serge; Nkoa, Francois C; Ondoa, Henri Atangana

doi:10.1186/1745-6215-12-5

Cited by 55 publications

(46 citation statements)

References 29 publications

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“…The Cameroon Mobile Phone SMS trial focused on ensuring compliance with antiretroviral treatment in patients from Cameroon. 23 This study confirmed that mobile telephones were an effective tool for remaining in contact with patients. The importance of biobanks in health development is understood in Africa.…”

Section: Discussionsupporting

confidence: 83%

Biobank–Short Message Service for Linking Patients and Samples

Tebbakha

2013

Telemedicine and e-Health

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A biobank is a biorepository that stores biological samples (usually of human origin) for use in research. Since the late 1990s, biobanks have become a key resource, supporting contemporary research in many fields, including genomics and personalized medicine. The ethical requirement for anonymity currently results in irreversible severing of the link between patients and their biobank samples. However, the maintenance of an anonymous link would increase patients' control over their samples and the efficacy of sample management. We propose a system for anonymous, real-time communication between the biobank and the patients providing samples based on the short message service (SMS) of mobile telephones. The patient and the biobank communicate via a cryptographic protocol, using a trusted third-party server. The biobank-SMS (BioK-SMS) communication system provides answers to certain persistent ethical questions relating to biobanking. BioK-SMS makes it easier to obtain renewed consent when required, gives patients more control over their samples, and protects their privacy.

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Section: Discussionsupporting

confidence: 83%

Biobank–Short Message Service for Linking Patients and Samples

Tebbakha

2013

Telemedicine and e-Health

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“…To date, published literature of larger studies using SMS has focused on antiretroviral therapy adherence for patients with HIV/AIDS, including sending a text message asking “how are you?” 37 and sending automatic text medication reminders. 12,14 A study protocol outlined how researchers proposed to use reminders with a motivational message, 38 but do not describe how the motivational messages were designed.…”

Section: Discussionmentioning

confidence: 99%

mHealth intervention development to support patients with active tuberculosis

et al. 2014

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Background Mobile Health (mHealth) based interventions have been increasingly used to improve a broad range of health outcomes. However, few researchers have reported on the process or the application of theory to guide the development of mHealth based interventions, or specifically for tuberculosis (TB) treatment management. Aims To describe the steps, process, and considerations in developing a text messaging-based intervention to promote treatment adherence and provide support to patients with active TB. Methods Traditional qualitative techniques, including semi-structured interviews, field notes, content analysis, iterative coding, and thematic analysis, were used to design and document the intervention development with a multidisciplinary team of researchers, clinicians, administrators, and patients who were in active TB treatment. The Information-Motivation-Behavioral Skills (IMB) model was used to guide the coding scheme for content analysis of patient-directed TB educational material and intervention development. Results The development steps included: a) establishing intervention components, including justifications, considerations, timing and frequency of components; b) developing educational messages, including cultural adaption, text or short message service (SMS) formatting, and prioritizing message delivery order; and c) determining implementation protocol. A set of 16 IMB-based messages were developed for the educational component. Final intervention development was achieved in 3 months. Conclusion A collaborative approach and application of a theory to guide the intervention design and development is supported. Although a collaborative approach was more time consuming, it resulted in a more responsive, culturally appropriate, and comprehensive intervention. Considerations for developing a text messaging based intervention are provided and may serve as a guide for similar interventions. Further empirical evidence is needed for applying the IMB model for adherence-promotion in TB efforts.

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“…Details can be obtained from the published protocol [13]. Using a parallel group design, eligible and consenting patients were randomized to intervention and control arms with a 1∶1 allocation ratio.…”

Section: Methodsmentioning

confidence: 99%

The Cameroon Mobile Phone SMS (CAMPS) Trial: A Randomized Trial of Text Messaging versus Usual Care for Adherence to Antiretroviral Therapy

et al. 2012

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BackgroundMobile phone technology is a novel way of delivering health care and improving health outcomes. This trial investigates the use of motivational mobile phone text messages (SMS) to improve adherence to antiretroviral therapy (ART) over six months.Methodology/Principal FindingsCAMPS was a single-site randomized two-arm parallel design trial in Yaoundé, Cameroon. We enrolled and randomized HIV-positive adults on ART, aged 21 years and above to receive a weekly standardized motivational text message versus usual care alone. The primary outcome was adherence measured using a visual analogue scale (VAS), number of doses missed (in the week preceding the interview) and pharmacy refill data. Outcomes were measured at 3 and 6 months. Service providers and outcome assessors were blinded to allocation. Analysis was by intention-to-treat. Between November and December 2010, 200 participants were randomized, with 101 in the intervention group and 99 in the control group. At 6 months, overall retention was 81.5%. We found no significant effect on adherence by VAS>95% (risk ratio [RR] 1.06, 95% confidence interval [CI] 0.89, 1.29; p = 0.542; reported missed doses (RR 1.01, 95% CI 0.87, 1.16; p>0.999) or number of pharmacy refills (mean difference [MD] 0.1, 95% CI: 0.23, 0.43; p = 0.617. One participant in the intervention arm reported a possible disclosure of status.Conclusions/SignificanceStandardized motivational mobile phone text messages did not significantly improve adherence to ART in this study. Other types of messaging or longer term studies are recommended.Registration1. Pan-African Clinical Trials Registry; PACTR201011000261458 2. Clinicaltrials.gov; NCT01247181

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The cameroon mobile phone sms (CAMPS) trial: a protocol for a randomized controlled trial of mobile phone text messaging versus usual care for improving adherence to highly active anti-retroviral therapy

Cited by 55 publications

References 29 publications

Biobank–Short Message Service for Linking Patients and Samples

Biobank–Short Message Service for Linking Patients and Samples

mHealth intervention development to support patients with active tuberculosis

The Cameroon Mobile Phone SMS (CAMPS) Trial: A Randomized Trial of Text Messaging versus Usual Care for Adherence to Antiretroviral Therapy

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