The Canges of Burned Wounds Microbiocenosis Under Intratissue Electrophoresis of Antibacterial Remedies

Petriuk, B. V.; Sydorchuk, Ruslan; Khomko, O. Y.; Sydorchuk, Larysa; Petriuk, Tatiyana A.; Khomko, Bogdan O.

doi:10.13187/ejm.2015.7.29

Cited by 3 publications

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“…Преобладание грамотрицательных бактерий, в част ности НФБ (P. aeruginosa и A. baumannii), в структуре микрофлоры биологических сред у пациентов различ ных отделений реанимации многопрофильных стациона ров отмечают и другие исследователи, определяя для этой группы бактерий наиболее важное этиологическое значение [15,18,19]. Авторы объясняют это контами нацией госпитальной микрофлорой, что особенно харак терно для ран, которые являются наиболее значимым источником инфекционных осложнений у ожоговых па циентов [18,20]. Факт присоединения внутрибольнич ной флоры дополнительно объясняется обнаружением в половине биологических образцов обследованных паци ентов (ран, ОДП и мочи) смешанных микробных ассоци аций с участием преимущественно НФБ.…”

Section: Discussionunclassified

“…является спорным. Частота обнаружения стафилококков у ожоговых па циентов в отделении интенсивной терапии по данным различных авторов составляет от 11,9%, 17,9 % [19,20] до 44,6%, 56,3% [18,22]. В нашем исследова нии Staphylococcus spp.…”

Section: Discussionunclassified

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Local microbiological monitoring as a basis for determining etiological significance of conditional pathogens: data from a burn intensive care unit

Yarets

Шевченко

et al. 2021

CMAC

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Objective. To assess the etiology of infections, microbial associations and antimicrobial resistance in a burn intensive care unit. Materials and Methods. A microbiological study of 1322 biological samples from 195 patients with extensive burns included 479 blood samples, 82 respiratory samples, 326 urine samples, and 435 wound samples. Antimicrobial susceptibility testing was performed, and coefficients of constancy and associativity (CA), as well as the Jaccard coefficient were calculated. Results. The etiology of infections was represented by: Pseudomonas aeruginosa – 23%, Acinetobacter baumannii – 19.1%, Enterococcus faecalis – 18.6%, Klebsiella pneumoniae – 8.2%, CoNS (coagulasenegative staphylococci) – 8.2%, Staphylococcus aureus – 7.1%, Candida albicans – 7.1%, Candida non-albicans – 3%, other species were isolated with a frequency of less than 2%. Majority of the above mentioned pathogens showed high associativity: non-fermenting rods (NFR), S. aureus, Enterobacterales, E. faecalis, Candida non-albicans formed associations in 60.0%, 88.8%, 83.0%, 83.3% and 65% of cases, respectively. The prevalence of methicillin-resistant strains of S. aureus and CoNS was 71% and 81%, respectively. CoNS showed higher resistance to fluoroquinolones and gentamicin compare to S. aureus: 42% vs 23%, 46% vs 29%, respectively (χ2 = 6.91; p = 0.086; χ2 = 6.58; p = 0.013). E. faecalis showed high resistance rates to aminoglycosides and fluoroquinolones (> 60%). All Gram-positive isolates were completely susceptible to vancomycin, linezolid, tigecycline, and teicoplanin. Resistance rates of Gram-negative bacteria (NFR, K. pneumoniae) to penicillins, cephalosporins, carbapenems (for NFR), and aminoglycosides were high (from 60% to 100%). The most active antimicrobial against NFR was colistin. Resistance of K. pneumoniae isolates to carbapenems was 23%, while other enterobacteria were highly susceptible to carbapenems. Conclusions. The implementation of the local microbiological monitoring made it possible to characterize the qualitative pathogen structure and antimicrobial resistance in our burns intensive care unit. This data will serve as the basis for improving of the infection control and antimicrobial stewardship.

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Section: Discussionunclassified

Local microbiological monitoring as a basis for determining etiological significance of conditional pathogens: data from a burn intensive care unit

Yarets

Шевченко

et al. 2021

CMAC

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“…Thermal burns remain an important problem in the clinic of surgical diseases. Particularly problematic are extensive and profound lesions that are accompanied by the development of burn disease, the presence of severe intoxication syndrome, determined by various factors, including the intestinal factor [1,2,3,4]. Along with other methods of detoxification, this presupposes the use of enterosorption [5,6].…”

Section: Introductionmentioning

confidence: 99%

Application of Galvanoenterosorption in Multimodal Treatment of Patients With Thermal Burns

Khomko¹,

Petryuk²,

Khomko³

et al. 2021

Khark. Surg. Sch.

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Abstract. Aim – to investigate the influence of enterosorption and its combination with intra-tissue electrophoresis (ITE) of antibacterial preparations on the proteolytic and fibrinolytic activity of blood plasma in patients with common thermal burns. Material and methods. Enterosorbtion detoxification by enterosgel was used in the multimodal treatment of 28 patients with thermal burns of II-IV stages. The drug was prescribed from 2-3 days after burn for 7-14 days, depending on the severity of the injury and manifestations of the intoxication syndrome. In 24 patients the treatment was complemented by galvanization of burn wounds with the preliminary introduction of antibacterial drugs. ITE began with 3-4 days after burn, taking into account the sensitivity of the microflora to antibiotics. The comparison group was made up of 30 patients with similar areas and depths of thermal burns receiving traditional treatment. Results and discussion. It was discovered that the inclusion of enterosorption in multimodal therapy of burns diminished the level of unlimited proteolysis, favoured the increase of the level of blood plasma fibrinolytic activity. Its combination with ITE of antibacterial agents (galvanoenterosorption) ensured a higher therapeutic effect. Common deep thermal burns are accompanied by a significant increase in proteolytic and fibrinolytic activity (FA) of blood. Inclusion of enterosorbtion in the integrated therapy of burns provides reduction of proteolytic activity and maintenance of a high level of FA of plasma, which reduces the risk of thromboembolic complications. Conclusion. Combined use of enterosorption and ITE of antibacterial agents (galvanoentersorption) with thermal burns provides a higher therapeutic effect.

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The results of bacterial contamination of dangerous and borderline cases of burns

Толстов

Novikov

Milyudin

et al. 2022

vmirvz

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The aim is to study the microbiological picture of purulent inflammation of superficial local burns in the center of thermal lesions of Samara.Material and methods. The etiological structure of local burn infection was analyzed in 29 patients with limited, borderline burns of I-II degree in all phases of the wound process. The collection of wound material was carried out in accordance with the requirements of the Methodological Guidelines of MU 4.2.2039-05 "Technique of collecting and transporting biomaterials to microbiological laboratories". The material was delivered to the laboratory in test tubes with a transport medium under isothermal conditions at a temperature of 20–22 °C within a day after collection.Results. The analysis of the etiological structure of burn infection showed that staphylococcus (St. aureus, St. warneri, St. gallinarium, St. spp, St. epidermidis) plays a leading role in microbiological examination – in 26 patients (89.6 %) and E. coli (E. coli) in 11 (37.9 %). There were no significant differences in the studied signs in the comparison groups (p > 0.05, p = 0.55, χ2 = 3.841).Conclusion. The obtained results of the etiological structure of purulent inflammation of limited burns are statistically reliable and can be used in the development of antibacterial agents for the treatment of burn infection.

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The Canges of Burned Wounds Microbiocenosis Under Intratissue Electrophoresis of Antibacterial Remedies

Cited by 3 publications

References 1 publication

Local microbiological monitoring as a basis for determining etiological significance of conditional pathogens: data from a burn intensive care unit

Local microbiological monitoring as a basis for determining etiological significance of conditional pathogens: data from a burn intensive care unit

Application of Galvanoenterosorption in Multimodal Treatment of Patients With Thermal Burns

The results of bacterial contamination of dangerous and borderline cases of burns

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