The cannabinergic system is implicated in the upregulation of central NGF protein by psychotropic drugs

Hassanzadeh, Parichehr; Rahimpour, Sina

doi:10.1007/s00213-010-2120-4

Cited by 27 publications

(22 citation statements)

References 57 publications

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“…The reduced expression of neurotrophins in tissues, serum and plasma has been demonstrated through the normalization of these values after clinical treatment (Hashimoto, 2010;Hassanzadeh and Rahimpour, 2011).…”

Section: Discussionmentioning

confidence: 97%

“…In an experimental study, chronic treatment with nortriptyline and citalopram antidepressants increased brain NGF levels (Hassanzadeh and Rahimpour, 2011). On the other hand, Martino et al (2013) demonstrated that patients with MDD had NGF serum levels reduced when compared with healthy controls, not being reversed by duloxetine antidepressant, possibly reflecting functional impairment in the adaptive neuroplasticity of stress in depressive disorders (Martino et al, 2013).…”

Section: Discussionmentioning

confidence: 98%

“…A study with suicide victims found a decrease in NGF levels in the hippocampus of suicide victims when compared with healthy controls (Banerjee et al, 2013). In addition, treatment with certain antidepressants has increased NGF levels in both clinical and experimental studies (Hassanzadeh and Rahimpour, 2011). Few studies have been performed to examine an association between NGF and suicide risk in a human population.…”

Section: Introductionmentioning

confidence: 97%

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Serum levels of nerve growth factor (NGF) in patients with major depression disorder and suicide risk

Wiener

Ferreira

Moreira

et al. 2015

Journal of Affective Disorders

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 97%

See 1 more Smart Citation

Serum levels of nerve growth factor (NGF) in patients with major depression disorder and suicide risk

Wiener

Ferreira

Moreira

et al. 2015

Journal of Affective Disorders

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“…We found no association between suicide risk and NGF levels; one possible explanation might be the characteristics of our sample, in which almost no one was taking any medication and probably was seeking attendance for the first time. However, treatment with antidepressants and electroconvulsive therapy increased NGF levels in both clinical and experimental studies 44,45. The psychopathology that was more prevalent included MDD, and the pathogenesis of these disorders is related to the regulation of multiple neurotrophic factors and associated NGF levels decreased in the early stages 46.…”

Section: Discussionmentioning

confidence: 99%

Mental disorders, functional impairment, and nerve growth factor

Salles¹,

Soares²,

Wiener³

et al. 2016

PRBM

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Nerve growth factor (NGF) is an important member of the neurotrophin family and its alteration has been associated with psychiatric disorders. Functionality consists of the activities that an individual can perform, as well as their social participation, which is an important factor in analyzing the carrier living conditions of subjects with psychiatric suffering. Several studies have evaluated functionality in bipolar disorder; however, no studies have evaluated the functionality in other mental disorders. There are also few studies investigating the association between functionality and the biological bases of mental disorders. This study aimed to evaluate the serum NGF levels in psychiatric patients and to verify a possible association between the serum neurotrophic levels and functionality. This was a cross-sectional study with a convenient sample obtained from the Public Mental Health Service from the south of Brazil. The final sample was composed of 286 patients enrolled from July 2013 to October 2014. Data was collected using a sociodemographic questionnaire, and the diagnosis was confirmed using the Mini International Neuropsychiatric Interview (M.I.N.I) and a Functioning Assessment Short Test. The serum NGF levels were determined using the enzyme-linked immunosorbent assay method. Statistical analyses were performed using IBM SPSS Statistic 21.0 software. NGF serum levels were increased significantly in patients with obsessive–compulsive disorder compared with patients with no obsessive–compulsive disorder (P=0.015). An increase in serum NGF levels in generalized anxiety disorder patients was observed compared with patients with no generalized anxiety disorder (P=0.047). NGF was negatively associated with autonomy (P=0.024, r=−0.136), work (P=0.040, r=−0.124), and cognition (P=0.024, r=−0.137), thereby showing that changes in serum levels of NGF are associated with functionality in mental disorders.

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“…Firstly, the lack of a control for the use of treatments of mood disorders, including antipsychotic and other medications, could have influenced the results 29–31. In addition, psychotic symptoms and cognitive impairments were not assessed.…”

Section: Discussionmentioning

confidence: 99%

Nerve growth factor variations in patients with mood disorders: no changes in eight weeks of clinical treatment

Liu

Zhang

Shen

et al. 2014

NDT

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BackgroundNerve growth factor (NGF) has received much attention for its role in mood disorders. The primary objective of the present study was to examine serum NGF levels in Chinese inpatients with depressive or manic episodes in the acute phase and to explore the changes in NGF levels after effective clinical treatments.MethodsOne hundred and seven consecutive inpatients and outpatients with mood disorders (30 with unipolar depression, 23 with bipolar depression, and 54 with bipolar mania), and 50 healthy controls were recruited. The serum NGF levels were detected by enzyme-linked immunosorbent assay.ResultsPatients with bipolar mania presented higher serum NGF levels compared to those of healthy controls. After 8 weeks of medical treatment, there were significant improvements in symptoms in patients, but no significant changes in NGF levels.ConclusionThe present findings may help to strengthen and expand the understanding of the role of NGF in the acute stages of mood disorders.

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The cannabinergic system is implicated in the upregulation of central NGF protein by psychotropic drugs

Abstract: The cannabinergic system is implicated in the mechanisms of action of certain psychotropic drugs including the upregulation of brain NGF levels. This provides a better understanding of the pathophysiological mechanisms underlying neuropsychiatric disorders, leading to novel drug design.

Cited by 27 publications

References 57 publications

Serum levels of nerve growth factor (NGF) in patients with major depression disorder and suicide risk

Serum levels of nerve growth factor (NGF) in patients with major depression disorder and suicide risk

Mental disorders, functional impairment, and nerve growth factor

Nerve growth factor variations in patients with mood disorders: no changes in eight weeks of clinical treatment

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