The carbon dioxide hydration activity of purified teleost red cell carbonic anhydrase. Inhibition by sulfonamides and anions

Novel inhibition of carbonic anhydrase isozymes I, II and III by carbamoyl phosphate

“…A concencarbonic anhydrase yet discovered. It is contration of 25 mM achieved total inhibition of siderably more inhibitory than Cl- [19,20] and its human red cell CA I and CA II, CA activity in a potency of CA III inhibition is comparable to that total human red cell lysate, and CA III from of acetazolamide [9,21].…”

“…The CA II isozymes have substantially the highest levels of CO2 hydratase and esterase @-nitrophenyl acetate) activities. In contrast, the CA III isozymes, abundant in red skeletal muscle and also present in liver of * To whom reprint requests should be addressed Urea cycie some mammals [6,7,9,12], possess notably low activities, whilst additionally possessing a novel low acid phosphatase activity [13], which tempts speculation that they fulfill an as yet unknown physiologic~ role other than the catalysis of CO2-hydration.…”

Association of Carbonic Anhydrase Activity with Carboxysomes Isolated from the Cyanobacterium Synechococcus PCC7942

“…11), or animal CAs, e.g. human CA II, which has an 15o of 2 nm (26). The sensitivity of CAcbx to EZ (Table II) and the fact that a lesion in CAcbx appears to produce a high C02-requiring phenotype (19) Fig.…”

Effects of pH and inhibitors on the absorption spectrum of cobalt(II)‐substituted carbonic anhydrase III from bovine skeletal muscle

“…Absorption spectrum Inhibitor aromatic and heterocyclic sulfonamides that are potent and specific inhibitors of isoenzymes I and II are rather poor inhibitors of the muscle isoenzyme [3,5]. Recently, it was shown [6] that rat muscle isoenzyme III is identical with the 'sulfonamide-resistant' carbonic anhydrase discovered in lper of male rats .…”

“…Carbonic anhydrase III has a much lower turnover number for CO2 hydration than isoenzymes I and II [2,3,5]. Furthermore, while isoenzymes I and II are effective catalysts of 4-nitrophenyl acetate hydrolysis, isoenzyme III has a very low esterase activity [2,3].…”