The carcinoembryonic antigen assay in bronchogenic carcinoma

Concannon, Joseph P.; Dalbow, Milton H.; Liebler, George A.; Blake, Karl E.; Weil, Carol S.; Cooper, J.

doi:10.1002/1097-0142(197407)34:1<184::aid-cncr2820340128>3.0.co;2-e

Cited by 69 publications

(4 citation statements)

References 12 publications

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“…The LUNX gene was mapped to a peri‐centromeric region of chromosome 20, where chromosomal aberrations have been reported in a variety of cancers, such as breast cancer, leukemia, pancreatic cancer and colon cancer 19–22. Furthermore, semi‐quantitative RT‐PCR showed that LUNX expression was more enhanced in most tumors compared with normal background lung tissues.…”

Section: Discussionmentioning

confidence: 99%

Isolation of a novel human lung-specific gene,LUNX, a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer

et al. 2001

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We have isolated a novel human lung‐specific gene, LUNX (lung‐specific X protein), by differential‐display mRNA analysis. The full‐length cDNA contained 1,015 nucleotides including an open reading frame of 768 nucleotides encoding 256 amino acids. We localized the gene to chromosomal region 20p11.1‐q12 by radiation hybrid mapping. Using an RT‐PCR assay specific for LUNX mRNA, 35 non‐small‐cell lung‐cancer (NSCLC) tumors and 0 of 16 normal lymph nodes were positive. Furthermore, LUNX mRNA expression was enhanced in 26 (84%) of 31 NSCLC tumors vs. corresponding cancer‐free lung tissues by semi‐quantitative analyses with multiplex RT‐PCR. We assessed the possibility of LUNX mRNA as a molecular marker for detection of micrometastasis in dissected lymph nodes obtained from 20 patients with NSCLC tumors. LUNX mRNA was detected in 16 (80%) of 20 histologically positive lymph nodes and 21 (25%) of 84 histologically negative lymph nodes. Comparative analyses of the conventional histological examination and the RT‐PCR detection assay for LUNX mRNA showed that the detection rate of metastases in lymph nodes by the RT‐PCR assay was higher in 12 and consistent in 6 of the total 20 NSCLC patients. We demonstrate that the LUNX RT‐PCR assay is a potential diagnostic method for detection of micrometastases in lymph nodes of NSCLC patients. © 2001 Wiley‐Liss, Inc.

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Section: Discussionmentioning

confidence: 99%

Isolation of a novel human lung-specific gene,LUNX, a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer

et al. 2001

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“…If it is intended to use the marker as a screening or diagnostic test, then it must be present in virtually 100% of cases. In this context, Concannon et al (1974) concluded that CEA is of no value in bronchial carcinoma. Similarly, if the marker is to be applied as a test for disseminated disease, and thus exclude patients who are unsuitable for surgery, it must correlate very closely with the presence of metastases.…”

Section: Discussionmentioning

confidence: 99%

Biochemical markers in bronchial carcinoma

McKenzie¹,

Evans²,

Hillyard³

et al. 1977

Br J Cancer

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“…Hansen6 in 1970 described the use of zirconylphosphate gel, the method that we have used for radioimmunoassay of CEA. 4 We believe it is now possible to give some appraisal of the value of CEA in the assessment of the lung cancer patient. In this investigation we are looking to answer, in part, the following questions: 1) Based on data from various control population groups, what concentration of CEA should be regarded as normal?…”

Section: E Increasing Incidence Of Lung Cancermentioning

confidence: 99%

Carcinoembryonic antigen in 228 patients with carcinoma of the lung

Vincent

Chu

Fergen

et al. 2010

Cancer

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Two hundred and twenty-eight patients who were treated for carcinoma of the lung were followed a n d their plasma CEA levels assessed at intervals during the course of the disease. In addition, plasma samples were taken from 487 healthy blood donors for comparison as a control. CEA assay is not selective or specific enough, at this time, to be used for screening purposes even though 68% of the patients who have lung cancer will have a n elevated concentration of CEA regardless of the histological cell type. In patients with plasma levels of CEA above 15 ng/ml the prognosis is uniformly poor. CEA in the authors' view does have value as a prognostic marker capable of suggesting the successful resection of a tumor and to a lesser degree confirming the clinical objective response to the radiotherapy or chemotherapy. It was found that the presence of CEA was not necessarily related to the volume of the tumor or the site of organ metastasis, but reflects the metabolic properties and characteristics of the individual tumor as it occurs in the patient.

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The carcinoembryonic antigen assay in bronchogenic carcinoma

Cited by 69 publications

References 12 publications

Isolation of a novel human lung-specific gene,LUNX, a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer

Isolation of a novel human lung-specific gene,LUNX, a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer

Biochemical markers in bronchial carcinoma

Carcinoembryonic antigen in 228 patients with carcinoma of the lung

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