The cardiac effects of carbon nanotubes in rat

Hosseinpour, Mina; Azimirad, Vahid; Alimohammadi, M.; Shahabi, Parviz; Sadighi, Mehrnoosh; Nejad, Ghazaleh Ghamkhari

doi:10.15171/bi.2016.11

Cited by 30 publications

(10 citation statements)

References 40 publications

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“…Depending on the doses of CNTs, some studies showed the persistent pulmonary inflammation 9 – 14 , transient inflammation 15 – 17 , and no inflammation 11 , 18 , 19 . It has been confirmed that CNTs can cause the cardiovascular toxicity 20 and increase susceptibility to cardiovascular diseases 21 such as ischemia 22 as well as an increase in the resting heart rate 23 . A very low neurotoxicity of CNTs was observed by Chen et al .…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: The toxicity and therapeutic effects of single-and multi-wall carbon nanotubes on mice breast cancer

Kavosi

Noei

Madani

et al. 2018

Sci Rep

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Herein, we have investigated the toxicity of SWCNTs and MWCNTs in vitro and in vivo, and assessed their therapeutic effects on a typical animal model of breast cancer in order to obtain: first, the cytotoxicity effects of CNTs on MC4L2 cell and mice, second the impact of CNTs on ablation of breast tumor. CNTs especially SWCNTs were toxic to organs and induced death at high dosages. In this case, some of the liver cells showed a relative shrinkage which was also confirmed by Annexin test in MC4L2 cells. Moreover, CNTs decreased the tumor volume. BCL2 gene was down-regulated, and BAX and Caspase-3 were also up-regulated in the treated groups with CNTs. As a result, CNTs especially MWCNT in lower dosages can be used as a promising drug delivery vehicle for targeted therapy of abnormal cells in breast cancer.

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Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: The toxicity and therapeutic effects of single-and multi-wall carbon nanotubes on mice breast cancer

Kavosi

Noei

Madani

et al. 2018

Sci Rep

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“…CNTs which are used today in the manufacture of cellular scaffolds and tissue engineering as well as in the circulatory system can cause significant toxicity in this organ. Studies showed that CNT increases the heart rate of rats and blocks the potassium channel leading to impaired blood pressure and uncoordinated heartbeat [121].…”

Section: Cntmentioning

confidence: 99%

“…The effects of SWCNTs on keratinocyte cells has been examined; they cause oxidative stress, increase ROSs and cytotoxicity by increasing the accumulation of peroxidation products, free radical production, and loss of macrophages [208,212]. Also, CNTs induce morphological changes in the skin and increase NF-kB [121]; [213], toxicity of these NPs being dosedependent. In a study of the toxicity of SWCNTs, increased (IL)-8 and cytokine expression and decreased cell viability has been reported; toxicity effects on skin cells in in vitro models were reported to be the toxicity of skin fibroblasts [129].…”

Section: Carbon-based Nanostructuresmentioning

confidence: 99%

Health concerns of various nanoparticles: A review of their in vitro and in vivo toxicity

Ajdari¹,

Moosavi²,

Rahmati³

et al. 2018

Preprint

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Nanoparticles (NPs) are widely used in diverse disciplines, including biology, medicine science. The central question that need to be answered is whether NPs have toxic effects on biological cells and molecules or are they safe. The safety of NPs including targeted drug delivery is critical and so is their toxicity in the environment. In recent years, in vitro and in vivo research on animals has generated abundant information about the toxicity of NPs.However, due to varying laboratory conditions, the comparison of the results from ensuing studies is somewhat unreliable. It should be noted that, depending on the type of production, NPs can enter the body through inhalation, skin and via digestive routes. Due to the diversity of NPs and their properties, there is paucity of accurate information on their toxicological effects; particle size, shape, surface area and the chemical levels are considered as key factors in creating health and toxicological effects. Consequently, there is a need for reliable information about their effects on various organs so as to deal with NPs effectively and their impact on health and the environment. This review covers the existing knowledge base on the subject that hopefully prepares us better to address these challenges.

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“…Use of stem cells or biologically compatible, synthetic compounds have been studied extensively, although with greater focus on effects on myocardial contractility and ventricular function rather than arrhythmogenicity. Certain compounds, such as carbon nanotubes, have been studied in a variety of biological approaches, including as a means of potentially enhancing myocardial health (5)(6)(7)(8)(9)(10)(11). One promising aspect of carbon nanotubes is that they are highly conductive.…”

Section: Introductionmentioning

confidence: 99%

Injectable conductive hydrogel restores conduction through ablated myocardium

Zyl

Pedrotty

Karabalut

et al. 2020

Preprint

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Introduction: Therapies for substrate-related arrhythmias include ablation or drugs targeted at altering conductive properties or disruption of slow zones in heterogeneous myocardium. Conductive compounds such as carbon nanotubes may provide a novel personalizable therapy for arrhythmia treatment by allowing tissue homogenization. Methods: A nanocellulosecarbon nanotube conductive hydrogel was developed to have conduction properties similar to normal myocardium. Ex vivo perfused canine hearts were studied. Electroanatomic activation mapping of the epicardial surface was performed at baseline, after radiofrequency ablation, and after uniform needle injections of the conductive hydrogel through the injured tissue. Gross histology was used to assess distribution of conductive hydrogel in the tissue. Results: The conductive hydrogel viscosity was optimized to decrease with increasing shear rate to allow expression through a syringe. The DC conductivity under aqueous conduction was 4.3•10-1 S/cm. In 4 canine hearts, when compared to the homogeneous baseline conduction, isochronal maps demonstrated sequential myocardial activation with a shift in direction of activation to surround the edges of the ablated region. After injection of conductive hydrogel, isochrones demonstrated conduction through the ablated tissue with activation similar to baseline in all 4 hearts. Gross specimen examination demonstrated retention of the hydrogel within the tissue. Conclusions: This proof-of-concept study demonstrates that conductive hydrogel can be injected into acutely disrupted myocardium to restore conduction. Future experiments should focus on evaluating long-term retention and biocompatibility of the hydrogel through in vivo experimentation.

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The cardiac effects of carbon nanotubes in rat

Cited by 30 publications

References 40 publications

RETRACTED ARTICLE: The toxicity and therapeutic effects of single-and multi-wall carbon nanotubes on mice breast cancer

RETRACTED ARTICLE: The toxicity and therapeutic effects of single-and multi-wall carbon nanotubes on mice breast cancer

Health concerns of various nanoparticles: A review of their in vitro and in vivo toxicity

Injectable conductive hydrogel restores conduction through ablated myocardium

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