The cardioprotective effect of total flavonoids on myocardial ischemia/reperfusion in rats

Lv, Dongling; Cheng, Xuansheng; Tang, Lingyi; Jiang, Meng

doi:10.1016/j.biopha.2017.01.060

Cited by 49 publications

(35 citation statements)

References 20 publications

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“…Many other nutraceuticals have been found to possess therapeutic potential in the treatment of cardiovascular diseases by attenuation of the NLRP3 inflammasome, such as luteolin [ 57 ] and dihydromyricetin [ 56 ] in atherosclerosis; and colchicine [ 58 ], triptolide [ 59 ], total flavones [ 60 ], umbelliferone [ 61 ] in ischemic myocardial disease.…”

Section: Nutraceutical Compounds the Nlrp3 Inflammasome And Cardimentioning

confidence: 99%

Nutraceutical Compounds Targeting Inflammasomes in Human Diseases

Castejón-Vega

Giampieri

Álvarez-Suarez

2020

IJMS

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The macromolecular complex known as “inflammasome” is defined as an intracellular multi-protein complex composed of a sensor receptor (PRR), an adaptor protein and an effector enzyme (caspase-1), which oligomerize when they sense danger, such as how the NLR family, AIM-2 and RIG-1 receptors protect the body against danger via cytokine secretion. Within the NLR members, NLRP3 is the most widely known and studied inflammasome and has been linked to many diseases. Nowadays, people’s interest in their lifestyles and nutritional habits is increasing, mainly due to the large number of diseases that seem to be related to both. The term “nutraceutical” has recently emerged as a hybrid term between “nutrition” and “pharmacological” and it refers to a wide range of bioactive compounds contained in food with relevant effects on human health. The relationship between these compounds and diseases based on inflammatory processes has been widely exposed and the compounds stand out as an alternative to the pathological consequences that inflammatory processes may have, beyond their defense and repair action. Against this backdrop, here we review the results of studies using several nutraceutical compounds in common diseases associated with the inflammation and activation of the NLRP3 inflammasomes complex. In general, it was found that there is a wide range of nutraceuticals with effects through different molecular pathways that affect the activation of the inflammasome complex, with positive effects mainly in cardiovascular, neurological diseases, cancer and type 2 diabetes.

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Section: Nutraceutical Compounds the Nlrp3 Inflammasome And Cardimentioning

confidence: 99%

Nutraceutical Compounds Targeting Inflammasomes in Human Diseases

Castejón-Vega

Giampieri

Álvarez-Suarez

2020

IJMS

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“…Some flavonoids are the most effective biologically active compounds in plants. These compounds might be useful as chemopreventive and therapeutic agents for cardiovascular disease 22 . The cardioprotective effect of flavonoids is attributed to their anti-oxidant, anti-inflammatory and anti-apoptotic properties 23 .…”

Section: Introductionmentioning

confidence: 99%

Pretreatment with Total Flavonoid Extract from Dracocephalum Moldavica L. Attenuates Ischemia Reperfusion-induced Apoptosis

Zeng

Wen

Yang

et al. 2018

Sci Rep

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We previously demonstrated the cardio-protection mediated by the total flavonoid extracted from Dracocephalum moldavica L. (TFDM) following myocardial ischemia reperfusion injury (MIRI). The present study assessed the presence and mechanism of TFDM-related cardio-protection on MIRI-induced apoptosis in vivo. Male Sprague-Dawley rats experienced 45-min ischemia with 12 h of reperfusion. Rats pretreated with TFDM (3, 10 or 30 mg/kg/day) were compared with Sham (no MIRI and no TFDM), MIRI (no TFDM), and Positive (trapidil tablets, 13.5 mg/kg/day) groups. In MIRI-treated rats, high dose-TFDM (H-TFDM) pre-treatment with apparently reduced release of LDH, CK-MB and MDA, enhanced the concentration of SOD in plasma, and greatly reduced the infarct size, apoptotic index and mitochondrial injury. H-TFDM pretreatment markedly promoted the phosphorylation of PI3K, Akt, GSK-3β and ERK1/2 in comparison with the MIRI model group. Western blot analysis after reperfusion also showed that H-TFDM decreased release of Bax, cleaved caspase-3, caspase-7 and caspase-9, and increased expression of Bcl-2 as evident by the higher Bcl-2/Bax ratio. TFDM cardio-protection was influenced by LY294002 (PI3K inhibitor) and PD98059 (ERK1/2 inhibitor). Taken together, these results provide convincing evidence of the benefit of TFDM pretreatment due to inhibited myocardial apoptosis as mediated by the PI3K/Akt/GSK-3β and ERK1/2 signaling pathways.

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“…exhibited notable cardioprotective activity by decreasing the levels of creatinine kinase, LDH, IL-6, IL-1β, and TNF-α in serum, increasing the activity of SOD, and reducing the MDA content in a rat model of myocardial ischemia–reperfusion. In addition, TFAM alleviated myocardial injury induced by ischemia–reperfusion in rats by suppressing the NLRP3 inflammasome ( Lv et al., 2017 ). Taken together, these results suggest that TFAM might be a candidate drug for treating cardiovascular diseases.…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

“…Modern pharmacological findings have shown that the extracts and active constituents of A. manihot possess various biological properties, including anti-DN ( Tu et al., 2013 ), anticonvulsant ( Guo et al., 2011 ), antioxidant ( Zhang et al., 2013 ), antiadipogenic, anti-inflammatory ( Jain and Bari, 2010 ), analgesic ( Fan et al., 2003 ), antidepressant ( Guo et al., 2011 ), antiviral ( Wu et al., 2007 ), antitumor ( Zheng et al., 2016 ), antiplatelet ( Guo et al., 2005 ), anti-Crohn’s disease ( Yang B. L. et al., 2018 ), anti-poststroke depression ( Liu et al., 2009 ), proangiogenic ( Zhu et al., 2018 ), cardioprotective ( Lv et al., 2017 ), neuroprotective ( Cheng et al., 2006 ), immunomodulatory ( Pan et al., 2018 ), and hepatoprotective ( Ai et al., 2013 ) properties, and are effective against cerebral infarction, bone loss ( Guo and Chen, 2002 ; Puel et al., 2005 ), etc. Many of these activities are consistent with those of A. manihot in traditional medicine and support traditional usage.…”

Section: Introductionmentioning

confidence: 99%

Traditional Uses, Chemical Constituents, Biological Properties, Clinical Settings, and Toxicities of Abelmoschus manihot L.: A Comprehensive Review

Luan

Wu²,

Yang

et al. 2020

Front. Pharmacol.

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Abelmoschus manihot , an annual herbal flowering plant, is widely distributed throughout eastern Europe and in temperate and subtropical regions of Asia. Its flowers have been traditionally used for the treatment of chronic kidney disease in China. Currently, more than 128 phytochemical ingredients have been obtained and identified from the flowers, seeds, stems, and leaves of A. manihot . The primary components are flavonoids, amino acids, nucleosides, polysaccharides, organic acids, steroids, and volatile oils. A. manihot and its bioactive constituents possess a plethora of biological properties, including antidiabetic nephropathy, antioxidant, antiadipogenic, anti-inflammatory, analgesic, anticonvulsant, antidepressant, antiviral, antitumor, cardioprotective, antiplatelet, neuroprotective, immunomodulatory, and hepatoprotective activities, and have effects on cerebral infarction, bone loss, etc. However, insufficient utilization and excessive waste have already led to a rapid reduction of resources, meaning that a study on the sustainable use of A. manihot is urgent and necessary. Moreover, the major biologically active constituents and the mechanisms of action of the flowers have yet to be elucidated. The present paper provides an early and comprehensive review of the traditional uses, chemical constituents, pharmacological activities, and pharmaceutical, quality control, toxicological, and clinical settings to emphasize the benefits of this plant and lays a solid foundation for further development of A. manihot .

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The cardioprotective effect of total flavonoids on myocardial ischemia/reperfusion in rats

Cited by 49 publications

References 20 publications

Nutraceutical Compounds Targeting Inflammasomes in Human Diseases

Nutraceutical Compounds Targeting Inflammasomes in Human Diseases

Pretreatment with Total Flavonoid Extract from Dracocephalum Moldavica L. Attenuates Ischemia Reperfusion-induced Apoptosis

Traditional Uses, Chemical Constituents, Biological Properties, Clinical Settings, and Toxicities of Abelmoschus manihot L.: A Comprehensive Review

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