The Cardiovascular Response to Arousal from Sleep Decreases with Age in Healthy Adults

Goff, Elizabeth A.; O'Driscoll, Denise Marie; Simonds, Anita K.; Trinder, John; Morrell, Mary J.

doi:10.5665/sleep/31.7.1009

Cited by 13 publications

(1 citation statement)

References 51 publications

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“…The degree of BP surge was even higher when compared with respiratory-related events. The degree of arousal related BP surge in our study was similar to that described with auditory-stimulation induced arousal [33]. Arousal-induced BP surge may represent one mechanism by which poor sleep quality is associated with hypertension.…”

Section: Discussionsupporting

confidence: 89%

Elucidation of obstructive sleep apnoea related blood pressure surge using a novel continuous beat-to-beat blood pressure monitoring system

Kwon

Baruch²,

Stafford³

et al. 2021

Journal of Hypertension

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Background: Obstructive sleep apnoea (OSA) episode related blood pressure (BP) surge may mediate the association of OSA with cardiovascular disease. However, BP is not measured during a clinical sleep study. Method:We tested the feasibility of incorporating the Caretaker physiological monitor, which utilizes a novel continuous beat-to-beat (b-b) BP monitoring technology, into polysomnography (PSG) and aimed to characterize BP surges related to obstructive respiratory events. B-b BP was concurrently collected and merged with PSG data on a posthoc basis. We compared BP surge between mean respiratory (apnoea, hypopnea and desaturation-alone events) and nonrespiratory events (spontaneous or leg movement-related arousals). We examined the association of the degree of oxygen desaturation with BP surge in a given respiratory event combining all events. A total of 17 consecutive patients (12 men, mean 52 years old, nine diagnostic and eight split-night PSGs) undergoing clinically indicated PSG were included after excluding one patient with poor signal quality due to excessive movement.Results: Caretaker was well tolerated. Mean respiratory BP surge ranged from 5 to 19 mmHg [Median (IQR) ¼ 13.9 (9.5-16.2)]. Mean BP surge between the respiratory and nonrespiratory events was similar [13.8 (4.5) vs. 14.9 (5.3) mmHg, P ¼ 0.13]. Accounting for the count distribution of desaturation/BP surge data pair events, there was a linear correlation between the degree of oxygen desaturation and BP surge (R ¼ 0.57, P < 0.001). In eight patients undergoing split-night sleep studies, the number of BP surge events (10 mmHg/h) decreased during continuous positive airway pressure in all but one patient. Conclusion:We demonstrated highly variable OSA-related BP surge patterns using the Caretaker's b-b BP monitoring technology that has the potential to be integrated into sleep studies.

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Section: Discussionsupporting

confidence: 89%

Elucidation of obstructive sleep apnoea related blood pressure surge using a novel continuous beat-to-beat blood pressure monitoring system

Kwon

Baruch²,

Stafford³

et al. 2021

Journal of Hypertension

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The independent and combined effects of respiratory events and cortical arousals on the autonomic nervous system across sleep stages

Liang

Zhang²,

et al. 2018

Sleep Breath

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Chronic intermittent hypoxia induces hormonal and male sexual behavioral changes: Hypoxia as an advancer of aging

Wilson

Anderson

Snyder

et al. 2018

Physiology & Behavior

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Sleep apnea is a common sleep disorder characterized by intermittent periods of low blood oxygen levels. The risk for sleep apnea increases with age and is more prevalent in men than women. A common comorbidity of sleep apnea includes male sexual dysfunction, but it is not clear if a causal relationship exists between sleep apnea and sexual dysfunction. Possible mechanisms that link these two disorders include oxidative stress and testosterone. Oxidative stress is elevated in clinical patients with sleep apnea and in rodents exposed to chronic intermittent hypoxia (CIH), an animal model for apnea-induced hypopnea. Further, oxidative stress levels increase with age. Therefore, age may play a role in sleep apnea-induced sexual dysfunction and oxidative stress generation. To investigate this relationship, we exposed gonadally intact 3 (young) and 12 (middle-aged) month old male F344/BN F1 hybrid male rats to 8 days of CIH, and then examined male sexual function. Plasma was used to assess circulating oxidative stress and hormone levels. Middle-aged male rats had lower testosterone levels with increased sexual dysfunction and oxidative stress, independent of CIH. However, CIH decreased testosterone levels and increased sexual dysfunction and oxidative stress only in young gonadally intact male rats, but not in gonadectomized young rats with physiological testosterone replacement. In sum, CIH had a greater impact on younger gonadally intact animals, with respect to sexual behaviors, testosterone, and oxidative stress. Our data indicate CIH mimics the effects of aging on male sexual behavior in young gonadally intact male rats.

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The Cardiovascular Response to Arousal from Sleep Decreases with Age in Healthy Adults

Cited by 13 publications

References 51 publications

Elucidation of obstructive sleep apnoea related blood pressure surge using a novel continuous beat-to-beat blood pressure monitoring system

Elucidation of obstructive sleep apnoea related blood pressure surge using a novel continuous beat-to-beat blood pressure monitoring system

The independent and combined effects of respiratory events and cortical arousals on the autonomic nervous system across sleep stages

Chronic intermittent hypoxia induces hormonal and male sexual behavioral changes: Hypoxia as an advancer of aging

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