This article explores researchers’ perceptions of discrepancies between the creative goals of research projects in which artists are recruited and requirements established by ethical review boards in higher education. It describes issues that researchers typically face when applying for the ethical clearance of research projects that engage various communities in participatory activities involving creative professionals. While the observation of ethical codes of practice is very important in all academic research, it is equally important to understand how the goals of research and artistic outcomes may be affected by regulatory procedures as well as variable institutional practices related to ethical reviews of research. Ethical requirements may impact research in any discipline and are certainly not unique to the arts, but it is important to understand the specific effects of ethics review boards on research projects that venture into new creative areas that might involve vulnerable participants or include unforeseeable artistic outcomes. The article analyses studies undertaken by a research team made of academics, artists and other entities at the University of Malta and shows how the ethics review process affects timeframes, levels of participants’ involvement and the organic development of creative processes. Finally, it makes some recommendations for ethical review boards in the evaluation of socially engaged arts research projects.