The Case for Branchiogenic Cancer (Malignant Branchioma)

Martin, Hayes; Hm, Morfit; Ehrlich, Harry E.

doi:10.1097/00000658-195011000-00002

Cited by 180 publications

(113 citation statements)

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“…The present case matched the criteria proposed by Khafif et al (2), but did not match those proposed by Martin et al (1), as the patient succumbed to distant metastasis within a 5-year period. Since normal squamous epithelium at the cyst wall and transition from dysplasia to carcinoma were observed, the case was judged to be a typical BC.…”

Section: Discussioncontrasting

confidence: 58%

“…Martin et al (1) proposed the following criteria for the diagnosis of BC, stating the fourth criterion as the most important for confirming BC. First, the cervical tumor must occur at a point along an imaginary line that extends between just anterior to the tragus of the ear and downward along the anterior border of the sternocleidomastoid (SCM) muscle to the clavicle.…”

Section: Introductionmentioning

confidence: 99%

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Branchiogenic carcinoma with high-risk-type human papillomavirus infection: A case report

et al. 2016

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Abstract. Branchiogenic carcinoma (BC) usually appears as a mass lesion with a predominant cystic component. Since lymph node metastasis from oropharyngeal carcinoma (OPC) has a cystic appearance, it is occasionally difficult to distinguish between BC and nodal metastases from clinically silent OPC. Factors associated with the malignant transformation process in BC remain obscure. The present study reports the case of a 56-year-old man with a right cystic cervical mass that was diagnosed as squamous cell carcinoma based on examination by fine-needle aspiration biopsy. The primary tumor could not be detected despite several imaging examinations, a pan-endoscopy of the head and neck, esophagus and stomach, biopsies of the head and neck regions, and bilateral tonsillectomies. The pathological findings of the surgical specimens from a radical neck dissection were consistent with the histological characteristics of BC, with evidence of transition from dysplasia through intraepithelial carcinoma to invasive carcinoma. Normal squamous epithelium and dysplastic and cancerous portions in the BC showed strong p16INK4a immunoreactivity. The expression of p16 INK4a was also observed in all 9 nodal metastases in the neck dissection specimens. The cystic formation observed in the BC was not observed in the nodal metastases. As the presence of human papillomavirus-16 in the tumor was confirmed by polymerase chain reaction, quantitative polymerase chain reaction was employed for the measurement of human papillomavirus-16 viral load and integration. The results showed that the viral load of human papillomavirus-16 was 3.01x10 7 /50 ng genomic DNA, and the E2/E6 ratio was 0.13, so the integration state was judged to be the mixed type. To the best of our knowledge, this is the first report of BC associated with high-risk-type human papillomavirus infection. The study indicates that a human papillomavirus-positive neck mass may not necessarily be OPC, but that it could be BC with a poor prognosis. This report lends support to the existence of BC and proposes that the etiology is human papillomavirus infection. IntroductionBranchiogenic carcinoma (BC) is an extremely rare malignant neck tumor that usually appears as a mass lesion with a prominent cystic component. Since oropharyngeal carcinoma (OPC) metastasis in the lymph nodes also has a cystic appearance, it is occasionally difficult to distinguish between BC and metastases in the cervical lymph nodes from clinically silent OPC.Martin et al (1) proposed the following criteria for the diagnosis of BC, stating the fourth criterion as the most important for confirming BC. First, the cervical tumor must occur at a point along an imaginary line that extends between just anterior to the tragus of the ear and downward along the anterior border of the sternocleidomastoid (SCM) muscle to the clavicle. Second, the histological appearance of the mass should be consistent with an origin from tissue known to be present in the branchial vestigia. Third, a survival period of at least 5 years, w...

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Section: Discussioncontrasting

confidence: 58%

Section: Introductionmentioning

confidence: 99%

Branchiogenic carcinoma with high-risk-type human papillomavirus infection: A case report

et al. 2016

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“…4) It must be demonstrated that cancer developed in the wall of an epithelial lined cyst situated in the lateral aspect of the neck. 4 Histologically the cyst is lined by stratified squamous epithelium or respiratory epithelium or sometimes both. Recurrent infection changes the lining epithelium in to a fibrous lining or a granulomatous lining.…”

Section: Discussionmentioning

confidence: 99%

Lymphoepithelial cyst of submandibular gland, a clinical dilemma- case report

Cheereth¹,

Paulose

Ninan³

2017

Int Surg J

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Swellings of the head and neck region present great difficulty in accurate diagnosis as well as proper management. Swelling associated with the maxilla and mandible has a tendency to be provisionally diagnosed as orofacial space infections, which is the most common cause for acute swelling in this region. Fine needle aspiration cytology (FNAC), ultrasonogram and computed tomography can be used in supporting diagnosis. It usually occurs due to the process of lymphocyte-induced cystic ductular dilatation and the confirmatory diagnosis is always made postoperatively by histopathological examination. The mainstay in the treatment of a lymphoepithelial cyst remains the surgical approach, which includes complete enucleation of the cyst along with total excision of the involved salivary gland. Here we present an interesting case of swelling in the right submandibular region which was provisionally diagnosed as submandibular space infection, but later proven histopathologically as a lymphoepithelial cyst of the submandibular gland.

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“…[1,2]. Branchial cyst presents as a smooth, soft ovoid cystic structure of the lateral neck originat ing in the remnant of an incompletely closed branchial cleft at the anterior margin of the sternocleidomastoid muscle.…”

Section: Klíčová Slovamentioning

confidence: 99%

Primary Branchiogenic Carcinoma

Hořáková¹,

Velecký²,

Pažourková³

et al. 2018

Klin Onkol

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SummaryBackground: Primary branchiogenic carcinoma (BC) is an exceptional dia gnostic entity. In most cases, suspicion of BC is confirmed to be a cystic lymph node metastasis of an occult primary tumor. Martin and Khafif therefore established dia gnostic criteria, emphasiz ing above all the importance of a histologically assessed transformation of cystic lin ing epithelium into an invasive squamous cell carcinoma in one pathological lesion after the exclusion of a primary tumor. Case report: We present a case report of an 80-year-old patient who presented for a follow-up for an 8-year history of a benign lateral cervical cyst, which was not surgically treated due to the patient's high risk of complications from general anesthesia. In spite of the risk, the surgery was performed after a sudden clinical progression, and surprisingly, post-operative histology revealed BC. Conslusion: BC is a very rare entity, strictly defined by Martin's and Khafif's criteria. Recently, BCs have been presented in the literature only as unique case reports respond ing as in our patient to the above mentioned criteria, with particular emphasis on the histological aspect, imag ing the cystic lin ing epithelium transform ing into an invasive squamous cell carcinoma in one pathological lesion and a long history without evidence of primary tumor.

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The Case for Branchiogenic Cancer (Malignant Branchioma)

Cited by 180 publications

References 0 publications

Branchiogenic carcinoma with high-risk-type human papillomavirus infection: A case report

Branchiogenic carcinoma with high-risk-type human papillomavirus infection: A case report

Lymphoepithelial cyst of submandibular gland, a clinical dilemma- case report

Primary Branchiogenic Carcinoma

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