The Catalytic Copolymerization of Ethene with Carbon Monoxide Efficiently Carried out in Water-Dichloromethane-Sodium Dodecylsulfate Emulsion

Vavasori, Andrea; Ronchin, Lucio; Quartarone, Giuseppe; Tortato, Claudio

doi:10.4236/mrc.2013.23014

Cited by 7 publications

(5 citation statements)

References 39 publications

(50 reference statements)

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“…MilliQ water was used for all experiments. The complexes [Pd(OAc)2(dppp)] were prepared as reported in literature [92]. Staphylococcus aureus ATCC 25923 strain was obtained from the American Type Culture Collection.…”

Section: Methodsmentioning

confidence: 99%

“…The average viscosity molecular weight of PK has been evaluated as Limit Viscosity Number (LVN), used m-cresol as solvent and the viscosity was measured by a Cannon-Fenske type capillary viscosimeter, thermostated at 25°C, as reported in literature [93].…”

Section: Methodsmentioning

confidence: 99%

“…After cooling to room temperature, a solid product was collected, filtered, and washed three times with methanol, acetone and diethyl ether. The resulting white powder polyketone (PK) was dried in vacuum for approximately 8 hours [92][93][94][95][96]. M.p.…”

Section: Synthesis Of Aliphatic Polyketones (Pk)mentioning

confidence: 99%

“…PK prepared according to literature method [68] (Mw = 15.272 g mol −1 determined as reported by Vavasori and coworkers [93]), was post-functionalized by Paal-Knorr reaction in the presence of taurinate or sulfanilate (1/1 molar ratio) at 70 °C, for 48 h in methanol as solvent (Scheme 1a, 1b). After work up (see experimental section), the solid polymers, recovered in high yields (2.3g, 80% and 1.96g, 85% respectively for PKSK and PKT), were characterized by FT-IR, DSC, TGA, SEM and elemental analysis.…”

Section: Synthesis Of Post Functionalized Pksmentioning

confidence: 99%

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Enhanced Antibacterial Activity of Vancomycin Loaded on Functionalized Polyketones

Rampazzo,

Vavasori,

Ronchin

et al. 2024

Preprint

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Today, polymeric Drug Delivery Systems (DDS) appear as an interesting solution against bacterial resistance, having great advantages such as low toxicity, biocompatibility, and biodegradability. In this work, two polyketones (PK) have been post-functionalized with taurinate (PKT) or sulfanilate (PKSK) and employed as biocompatible carriers for Vancomycin against bacterial infections. Mod-ified PKs were easily prepared by Paal-Knorr reaction and loaded with Vancomycin at variable pH. All polymers were characterized by FT-IR, DSC, TGA, SEM and elemental analysis. Antimicrobial activity was tested against Gram positive Staphylococcus aureus ATCC 25923 and correlated to the different pH used for its loading (between 2.3 and 8.8). Distinctively, minimum inhibitory con-centrations achieved with PKT and PKSK loaded with Vancomycin are similar, 0.23μg/mL and 0.24μg/mL respectively, i.e. six times lower that Vancomycin alone. The use of post-functionalized aliphatic polyketones has thus been demonstrated to be a promising way to obtain very efficient polymeric DDS.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Synthesis Of Aliphatic Polyketones (Pk)mentioning

confidence: 99%

Section: Synthesis Of Post Functionalized Pksmentioning

confidence: 99%

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Enhanced Antibacterial Activity of Vancomycin Loaded on Functionalized Polyketones

Rampazzo,

Vavasori,

Ronchin

et al. 2024

Preprint

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“…The CO-ethene copolymerization has been carried out in H 2 O/CH 2 Cl 2 mixtures in the presence of SDS. In the presence of an excess of TsOH (TsOH:Pd = 100:1), with 20 molar % CH 2 Cl 2 in H 2 O, 10 mM SDS, at 90 °C, 45 bar, CO:ethene = 1:1, 13 kg PK(g·Pd·h) −1 having LVN = 1.8 dLg −1 have been obtained [132].…”

Section: Carbonylation In Aqueous Solventsmentioning

confidence: 99%

Carbonylation of Ethene Catalysed by Pd(II)-Phosphine Complexes

Cavinato

Toniolo

2014

Molecules

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This review deals with olefin carbonylation catalysed by Pd(II)-phosphine complexes in protic solvents. In particular, the results obtained in the carbonylation with ethene are reviewed. After a short description of the basic concepts relevant to this catalysis, the review treats in greater details the influence of the bite angle, skeletal rigidity, electronic and steric bulk properties of the ligand on the formation of the products, which range from high molecular weight perfectly alternating polyketones to methyl propanoate. It is shown that the steric bulk plays a major role in directing the selectivity. Particular emphasis is given to the factors governing the very active and selective catalysis to methyl propanoate, including the mechanism of the catalytic cycles with diphosphine-and monophosphine-catalysts. A brief note on the synthesis of methyl propanoate using a "Lucite" type catalyst in ionic liquids is also illustrated. A chapter is dedicated to the carbonylation of olefins in aqueous reaction media. The nonalternating CO-ethene copolymerization is also treated.

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Polyketones: Synthesis and Applications

Vavasori

Ronchin

2017

Encyclopedia of Polymer Science and Technology

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Polyketones, also known as aliphatic polyketone, are a relatively new class of polymers obtained by the perfectly alternating copolymerization or terpolymerization of α-olefins with carbon monoxide. The polymerization is well catalyzed by Pd(II) complexes; the activity of which strongly depends by the nature of the ligand, promoting agents, and solvent used. Owing to their excellent mechanical properties, thermoplastic polyketones have found diverse industrial applications ranging from fibers, fire-retardant materials, and film coatings to membranes, packaging materials, and adhesives. Herein, we review the synthesis, properties, and applications of polyketones. In addition, industrial production of polyketone is also discussed

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The Catalytic Copolymerization of Ethene with Carbon Monoxide Efficiently Carried out in Water-Dichloromethane-Sodium Dodecylsulfate Emulsion

Abstract: The CO-ethene copolymerization has been efficiently carried out in the water/CH 2 Cl 2 emulsion by using water insolvable Pd(II) complexes. By using the surfactant SDS very high molecular weight copolymers have been obtained with high productivity (ca. 13,000 g/(gPd.h)).

Cited by 7 publications

References 39 publications

Enhanced Antibacterial Activity of Vancomycin Loaded on Functionalized Polyketones

Enhanced Antibacterial Activity of Vancomycin Loaded on Functionalized Polyketones

Carbonylation of Ethene Catalysed by Pd(II)-Phosphine Complexes

Polyketones: Synthesis and Applications

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