The Catalytic Preparation of Ether From Alcohol by Means of Aluminum Oxide

Clark, Robert H.; Graham, W. E.; Winter, A. G.

doi:10.1021/ja01688a016

Cited by 18 publications

(4 citation statements)

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“…The most reliable determinations appear to have been those of Semerano (&), Newitt and Semerano (52), Clark, Graham, and Winter (11) (all at about 250"C.), and a hitherto unpublished one of Atherton ( 5 ) a t 135°C. A recent study by Valentin (53) over a fairly considerable range of temperature appears to be far out of line with other results and would indicate that reaction (2) is strongly endothermic, which is highly improbable according to the thermal data of Table 2.…”

Section: B ( 4 3 )mentioning

confidence: 94%

Equilibria in the hydration of ethylene at elevated pressures and temperatures

Cope

Dodge

1959

AIChE Journal

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Values of equilibrium composition for the hydration of ethylene to form ethanol have been calculated for a series of elevated pressures and temperatures by using equilibrium data available from previous low-pressure studies. To obtain satisfactory agreement between these values and those measured experimentally, it is essential (I! to take into account the formation of ethyl ether and (2) to use available vapor-liquid equilibrium data for the binary ethanol-water system at elevated temperatures, instead of the standard "mixture rules" often employed.Thermochemical data and low-pressure equilibrium data for both the ethylene hydratiod and ether formation reactions are critically reviewed. Experimentally measured values for the equilibrium concentrations of ethanol and ether in the liquid phase at 221°C. and 273 atm., with dilute sulfuric acid used as catalyst in a lined rocking-bomb reactor, are presented.

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Section: B ( 4 3 )mentioning

confidence: 94%

Equilibria in the hydration of ethylene at elevated pressures and temperatures

Cope

Dodge

1959

AIChE Journal

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“…Brønsted acids can catalyze the formation of ethers when starting from two alcohol molecules, and this synthetic strategy is particularly useful for the preparation of symmetrical lower alkyl ethers. For instance, diethyl ether can be prepared by vapor‐phase dehydration of ethanol in a fixed‐bed reactor using alumina catalyst 3. 4 Many studies in homogeneous phases have been carried out with sulfuric acid 5.…”

Section: Etherification Of 1‐butanol (2) With Para‐methoxybenzyl Alcomentioning

confidence: 99%

A General Method for the Preparation of Ethers Using Water‐Resistant Solid Lewis Acids

Corma¹,

Renz²

2006

Angewandte Chemie

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Eine umweltfreundliche Kaskade: Wasserbeständige isolierte Lewis‐Säure‐Zentren im Gerüst von Molekularsieben sind ausgezeichnete allgemeine Katalysatoren für die Ethersynthese (siehe Schema). Auf dieser Grundlage wurde ein umweltfreundlicher Prozess für die Synthese von Feinchemikalien entwickelt, der eine Eintopfkaskade aus Meerwein‐Ponndorf‐Verley‐Reduktion und Veretherung umfasst.

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“…4). It is important to mention that several ether derivatives have been synthesized using some reagents such as aluminum oxide [27], zinc chloride [28], 2,2′dibromo-4,4′ dini trobenzophenone [29], and dimethyl sulfoxide [30]. In this study, the compound 7 was prepared via displacement of nitro group from 3,5-dinitrobenzoic acid with 6 in presence of dimethyl sulfoxide at mild conditions.…”

Section: Results and Discussion Evaluation Chemistrymentioning

confidence: 99%

Design and synthesis of a new steroid-macrocyclic derivative with biological activity

et al. 2017

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The aims of this study were to evaluate the positive inotropic effect of a new macrocyclic derivative (compound 11) and characterize the molecular mechanism involved in its biological activity. The first step was achieved by synthesis of a macrocyclic derivative involving a series of reactions for the preparation of several steroid derivatives such as (a) steroidpyrimidinone (3 and 4), (b) steroid-amino (5), (c) steroidimino (6), (d) ester-steroid (7 and 8), and (e) amido-steroid (9 and 10). Finally, 11 was prepared by removing the tertbutyldimethylsilane fragment of 10. The biological activity of compounds on perfusion pressure and vascular resistance was evaluated on isolated rat heart using the Langendorff model. The inotropic activity of 11 was evaluated in presence of prazosin, metoprolol, indomethacin, nifedipine, and flutamide to characterize its molecular mechanism. Theoretical experiments were carried out with a Docking model, to assess potential interactions of androgen receptor with 11. The results showed that only this macrocyclic derivative exerts changes on perfusion pressure and vascular resistance translated as the positive inotropic effect, and this effect was blocked with flutamide; these data indicate that the positive inotropic activity induced by this macrocyclic derivative was via androgen receptor activation. The theoretical results indicated that the interaction of the macrocyclic derivative with the androgen receptor involves several amino acid residues such as Leu 704 , Asn 705 , Met 780 , Cys 784 , Met 749 , Leu 762 , Phe 764 , Ser 778 , and Met 787 . In conclusion, all these data suggest that the positive inotropic activity of the macrocyclic derivative may depend on its chemical structure.

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The Catalytic Preparation of Ether From Alcohol by Means of Aluminum Oxide

Cited by 18 publications

References 0 publications

Equilibria in the hydration of ethylene at elevated pressures and temperatures

Equilibria in the hydration of ethylene at elevated pressures and temperatures

A General Method for the Preparation of Ethers Using Water‐Resistant Solid Lewis Acids

Design and synthesis of a new steroid-macrocyclic derivative with biological activity

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