The cause and correction of low blood vitamin C concentrations in the elderly

Newton, H. M. V.; Schorah, C. J.; Habibzadeh, Nasim; Morgan, Diane; Hullin, R. P.

doi:10.1093/ajcn/42.4.656

Cited by 38 publications

(17 citation statements)

References 11 publications

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“…2). In two studies, a decrease in the slope of plasma AA concentration (close to a plateau) was attained when vitamin Dietary Vitamin, mg/d intake was 100 and 500 mg/day respectively [58,59]. The favorable effect of AA intake on blood pressure and serum cholesterol observed in this study, has been reported [60).…”

Section: Evaluation Of Vitamin Needssupporting

confidence: 68%

Estimation of vitamin needs—riboflavin, vitamin B6 and ascorbic acid-according to blood parameters and functional-cognitive and emotional indices in a selected well-established group of elderly in a home for the aged in Israel.

Dror

Stern

Nemesh

et al. 1996

Journal of the American College of Nutrition

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On the basis of limited available data, calculation of vitamin needs based on regression lines resulted in estimates (mg/day) of: > 150 for ascorbic acid, > 3 for riboflavin, > 3 for vitamin B6. Expanding the current practice of supplementing micronutrients at a level of 100% RDA (in tablet form) that already exists in some elderly societies should be considered after a comprehensive study in a large group of elderly people.

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Section: Evaluation Of Vitamin Needssupporting

confidence: 68%

Estimation of vitamin needs—riboflavin, vitamin B6 and ascorbic acid-according to blood parameters and functional-cognitive and emotional indices in a selected well-established group of elderly in a home for the aged in Israel.

Dror

Stern

Nemesh

et al. 1996

Journal of the American College of Nutrition

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show abstract

“…a dietary intake resulting in a plasma concentration of approximately 70 mmol/l (3,27 -30) . Defining vitamin C deficiency is also complex since considerable individual variation apparently exists in the relationship between the plasma concentration of vitamin C and the development of scurvy, the classic hallmark of severe vitamin C deficiency (31,32) . Moreover, the clinical significance of vitamin C deficiency -beyond that of scurvy -has not been clearly defined.…”

Section: Clinical Significance and Prevalence Of Vitamin C Deficiencymentioning

confidence: 99%

“…those diagnosed with severe vitamin C deficiency. However, far from all individuals with plasma levels , 11 mmol/l develop clinical scurvy (31,32) . Thus, other factors seem to be of importance and the relationship between plasma vitamin C status and scurvy is not entirely clear, when the diet is not totally depleted from the vitamin.…”

Section: Severe Vitamin C Deficiencymentioning

confidence: 99%

Is vitamin C supplementation beneficial? Lessons learned from randomised controlled trials

2009

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In contrast to the promised 'antioxidant miracle' of the 1980s, several randomised controlled trials have shown no effect of antioxidant supplements on hard endpoints such as morbidity and mortality. The former over-optimistic attitude has clearly called for a more realistic assessment of the benefit:harm ratio of antioxidant supplements. We have examined the literature on vitamin C intervention with the intention of drawing a conclusion on its possible beneficial or deleterious effect on health and the result is discouraging. One of several important issues is that vitamin C uptake is tightly controlled, resulting in a wide-ranging bioavailability depending on the current vitamin C status. Lack of proper selection criteria dominates the currently available literature. Thus, while supplementation with vitamin C is likely to be without effect for the majority of the Western population due to saturation through their normal diet, there could be a large subpopulation with a potential health problem that remains uninvestigated. The present review discusses the relevance of the available literature on vitamin C supplementation and proposes guidelines for future randomised intervention trials.

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“…Reference values given are derived from extensive studies of vitamin levels in normal individuals, including those in institutions and elderly at home (Newton et al, 1985; Schorah 'personal communication'). The mean plasma vitamin C level of weight-losing cancer patients (0.5 ± 0.09 mg dl-') was lower (P <0.05) compared with weight-stable counterparts (0.8 ± 0.11 mg dl-').…”

Section: Resultsmentioning

confidence: 99%

“…The reference values quoted in Table II are derived from these studies (Newton et al, 1985; C.J. Schorah 'personal communication').…”

mentioning

confidence: 99%

Micronutrients in gastrointestinal cancer

Georgiannos

Weston²,

Goode³

1993

Br J Cancer

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Summary The monitoring of micronutrients and the relationship between dietary intake and micronutrient status prior to and after surgery in patients with histologically proven gastrointestinal adenocarcinoma, both weight-stable and weight-losing (> 7.5% of their pre-illness weight) has been studied and the results compared to controls.Plasma vitamin C and red blood cell thiamine levels were significantly lower in weight-losing cancer patients when compared to their weight-stable counterparts (P<0.05 and P<0.02 respectively). Weight-losing patients had a lower vitamin C (P<0.05) and thiamine (P <0.002) intake, and a higher elevation in plasma C-reactive protein and a lower prealbumin level (P<0.02), when compared to both weight-stable cancer patients and controls.Plasma vitamin C, prealbumin and C-reactive protein levels remained unchanged after curative resections of the tumours compared to a preoperative value, and there was a highly significant correlation between plasma vitamin C and dietary intake of vitamin C. This study suggests that the lower vitamin C and thiamine status in weight-losing gastrointestinal cancer patients prior to surgery is due to a lower micronutrient intake and an acute phase response to their illness. Dietary intake of vitamin C appears to be the major factor in determining plasma vitamin C concentration following curative surgical resection.

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The cause and correction of low blood vitamin C concentrations in the elderly

Cited by 38 publications

References 11 publications

Estimation of vitamin needs—riboflavin, vitamin B6 and ascorbic acid-according to blood parameters and functional-cognitive and emotional indices in a selected well-established group of elderly in a home for the aged in Israel.

Estimation of vitamin needs—riboflavin, vitamin B6 and ascorbic acid-according to blood parameters and functional-cognitive and emotional indices in a selected well-established group of elderly in a home for the aged in Israel.

Is vitamin C supplementation beneficial? Lessons learned from randomised controlled trials

Micronutrients in gastrointestinal cancer

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