The CCHamide 1 receptor modulates sensory perception and olfactory behavior in starved Drosophila

Abstract

The olfactory response of the vinegar fly Drosophila melanogaster to food odor is modulated by starvation. Here we show that this modulation is not restricted to food odors and their detecting sensory neurons but rather increases the behavioral response to odors as different as food odors, repellents and pheromones. The increased behavioral responsiveness is paralleled by an increased physiological sensitivity of sensory neurons regardless whether they express olfactory or ionotropic receptors and regardless whether they are housed in basiconic, coeloconic, or trichoid sensilla. Silencing several genes that become up-regulated under starvation confirmed the involvement of the short neuropeptide f receptor in the starvation effect. In addition it revealed that the CCHamide-1 receptor is another important factor governing starvation-induced olfactory modifications.

Chemical identity, function and regulation of enteroendocrine peptides in insects

“…Down-regulation of the CCHamide-1 receptor by RNAi in olfactory neurons in the antenna of adult D. melanogaster similarly affects food seeking behavior after starvation [45]. Possibly, CCHamide-1 released by the enteroendocrine cells during starvation might act on the olfactory neurons involved, but CCHamide-1 might also originate from brain interneurons [24].…”

bHLH proneural genes as cell fate determinants of entero-endocrine cells, an evolutionarily conserved lineage sharing a common root with sensory neurons

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The good, the bad, and the hungry: how the central brain codes odor valence to facilitate food approach in Drosophila

“…Starvation increases on one hand the sensitivity of ORNs to food odors through neuromodulatory mechanisms [4,6]. Short neuropeptide F (sNPF), which is expressed in ORNs, facilitates synaptic transmission in specific ORNs, while the expression level of the sNPF receptor is increased by a reduction of insulin signaling [4].…”

“…Odors are among the primary cues guiding such foraging behavior. Significant advances are being made in understanding how metabolic state alters the sensitivity of primary neurons along the olfactory axis, promoting foraging behavior [4,5*,6]. Yet comparatively little is known about how downstream elements of olfactory circuits shape this received sensory information and their effects on the locomotor behaviors that support eventual food acquisition.…”