The CD44 ligand hyaluronic acid is elevated in the cerebrospinal fluid of suicide attempters and is associated with increased blood–brain barrier permeability

Ventorp, Filip; Barzilay, Ran; Erhardt, Sophie; Samuelsson, Martin; Träskman‐Bendz, Lil; Janelidze, Shorena; Weizman, Abraham; Offen, Daniel; Brundin, Lena

doi:10.1016/j.jad.2015.12.069

Cited by 30 publications

(29 citation statements)

References 57 publications

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“…Schnieder et al (2014) reported similar findings, where they observed increased density of perivascular cells in prefrontal cortex white matter of suicide victims. It is known that peripheral cytokines can be trafficked into the CNS either through regions with limited blood-brain barrier (BBB) permeability, such as the circumventricular organs and the choroid plexus, or through a compromised BBB (Dantzer et al, 2008), which has been reported to be leaky in suicidal individuals (Bayard-Burfield et al, 1996;Falcone et al, 2010;Ventorp et al, 2016). In line with these findings, Wohleb et al demonstrated increased peripheral myeloid cell trafficking into perivascular spaces and specific brain regions using a repeated social defeat stress model.…”

Section: Inflammation and Symptoms Of Suicidalitymentioning

confidence: 92%

“…Inflammatory cytokines can be synthesized in the central nervous system or enter the brain from the periphery via different mechanisms, including compromised BBB. We have previously shown that suicide attempters have an increased BBB permeability, which is associated with increased CSF levels of glycosaminoglycan hyaluronic acid, which is a ligand for CD44 and is indicative of increased neuroinflammation (Ventorp et al, 2016).…”

Section: Neuroimmunological Mechanisms Involved In Suicidal Behaviormentioning

confidence: 99%

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Role of Inflammation in Suicide: From Mechanisms to Treatment

Brundin

Bryleva

Rajamani

2016

Neuropsychopharmacol

189

137

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Suicidal behavior is complex and manifests because of a confluence of diverse factors. One such factor involves dysregulation of the immune system, which has been linked to the pathophysiology of suicidal behavior. This review will provide a brief description of suicidality and discuss the contribution of upstream and downstream factors in the etiology of suicidal behavior, within the contextual framework of inflammation. The contribution of inflammatory conditions such as traumatic brain injury, autoimmune disorders, and infections to neuropsychiatric symptoms and suicidality is only beginning to be explored. We will summarize studies of inflammation in the etiology of suicide, and provide a neurobiological basis for different mechanisms by which inflammation might contribute to the pathophysiology. Finally, we will review treatments that affect upstream and downstream pathways related to inflammation in suicidality.

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Section: Inflammation and Symptoms Of Suicidalitymentioning

confidence: 92%

Section: Neuroimmunological Mechanisms Involved In Suicidal Behaviormentioning

confidence: 99%

Role of Inflammation in Suicide: From Mechanisms to Treatment

Brundin

Bryleva

Rajamani

2016

Neuropsychopharmacol

189

137

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“…Furthermore, LMW-HA induces NF-κB signaling and increases the expression of TNF-α and IL-1β in cultured neurons ( 77 ). Recent studies also suggested that HA concentration in cerebrospinal fluid is corelated to increased blood-brain barrier permeability ( 78 ).…”

Section: Hyaluronan and Neuroinflammationmentioning

confidence: 99%

Extracellular matrixes and neuroinflammation

et al. 2020

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The extracellular matrix is a critical component of every human tissue. ECM not only functions as a structural component but also regulates a variety of cellular processes such as cell migration, differentiation, proliferation, and cell death. In addition, current studies suggest that ECM is critical for the pathophysiology of various human diseases. ECM is composed of diverse components including several proteins and polysaccharide chains such as chondroitin sulfate, heparan sulfate, and hyaluronic acid. Each component of ECM exerts its own functions in cellular and pathophysiological processes. One of the interesting recent findings is that ECM is involved in inflammatory responses in various human tissues. In this review, we summarized the known functions of ECM in neuroinflammation after acute injury and chronic inflammatory diseases of the central nerve systems.

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“…[6] Studies reveal that suicidality and BD are independently associated with raised MMP-9 levels. [7,8] The present study aimed to evaluate the relationship between MMP-9 levels and lifetime history of suicide attempt in remitted BD-I patients.…”

Section: Relationship Between Matrix Metalloproteinase-9 and Lifetimementioning

confidence: 99%