The cell and developmental biology of alkaloid biosynthesis

Luca, Vincenzo De; St-Pierre, Benoit

doi:10.1016/s1360-1385(00)01575-2

Cited by 323 publications

(174 citation statements)

References 27 publications

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“…Our results suggest that leaf mechanical traits (toughness and trichome density) were better predictors of plant species strength and herbivore selectiveness than the percentage of oxidized phenolics. However, because chemical defenses are more specifi c and diverse than mechanical defenses ( Coley and Barone, 1996 ;de Luca and St Pierre, 2000 ), future studies should consider other compounds related to resistance traits, such as saponins, alkaloids, and/or cyanogenic compounds.…”

Section: Discussionmentioning

confidence: 99%

Influence of plant resistance traits in selectiveness and species strength in a tropical plant‐herbivore network

López-Carretero

Boege

Díaz‐Castelazo

et al. 2016

American J of Botany

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PREMISE OF THE STUDY:Plant-herbivore networks are highly specialized in their interactions, yet they are highly variable with regard to the relative importance of specifi c host species for herbivores. How host species traits determine specialization and species strength in this antagonistic network is still an unanswered question that we addressed in this study. METHODS:We assessed plant cover and antiherbivore resistance traits to assess the extent to which they accounted for the variation in specialization and strength of interactions among species in a plant-herbivore network. We studied a tropical antagonistic network including a diverse herbivore-host plant assemblages in diff erent habitat types and climatic seasons, including host plants with diff erent life histories.KEY RESULTS: Particular combinations of leaf toughness, trichome density, and phenolic compounds infl uenced herbivore specialization and host species strength, but with a signifi cant spatiotemporal variation among plant life histories. Conversely, plant-herbivore network parameters were not infl uenced by plant cover. CONCLUSIONS:Our study highlights the importance of species-specifi c resistance traits of plants to understand the ecological and evolutionary consequences of plant-herbivore interaction networks. The novelty of our research lies in the use of a trait-based approach to understand the variation observed in diverse plant-herbivore networks.

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Section: Discussionmentioning

confidence: 99%

Influence of plant resistance traits in selectiveness and species strength in a tropical plant‐herbivore network

López-Carretero

Boege

Díaz‐Castelazo

et al. 2016

American J of Botany

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“…This presents an enormous challenge for the researcher trying to assay these compounds in a massively parallel fashion. Thus far, only 50,000 compounds have been identified from a large number of species [20], highlighting the difficult nature of the task and the existence of thousands of undiscovered compound with different physical and chemical properties. Approximately 5,000-25,000 compounds may be produced in a single plant at a given developmental age and environmental state [61,95,99].…”

Section: Introductionmentioning

confidence: 99%

Metabolite Measurements

Roessner¹,

Beckles²

2008

Plant Metabolic Networks

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“…Vindoline and catharanthine are the major monomer alkaloids as well as biosynthetic precursors for the "dimeric" alkaloids, vinblastine and vincristine, two well known anticancer drugs used in the treatment of acute leukemia and Hodgkin's disease [1]. Low "dimeric" alkaloid contents in the plant have encouraged intense research for alternative production methods involving cell cultures [2,3], metabolic engineering [4], semi-synthesis [5,6] or even total chemical synthesis [7]. Total synthesis has proved difficult due to structural complexity of the molecules and complicated reaction steps involving stereochemical constraints.…”

Section: Introductionmentioning

confidence: 99%

A Simplified Procedure for Indole Alkaloid Extraction from Catharanthus roseus Combined with a Semi-synthetic Production Process for Vinblastine

et al. 2007

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Dried leaves of Catharanthus roseus were extracted with aqueous acidic 0.1 M solution of HCl. Alkaloid-embonate complexes were obtained as precipitates by treating the extract with an alkaline (NaOH) solution of embonic acid (4,4'-methylene-bis-3-hydroxynaphtalenecarboxylic acid). The precipitate mainly consisted of catharanthine and vindoline embonates and it was directly used as the starting material for a semisynthesis of the anti-cancer bisindole alkaloid vinblastine. The coupling reaction involved oxidation of catharanthine in aqueous acidic medium by singlet oxygen ( 1 O 2 ), continuously produced in situ by the reaction between H 2 O 2 with NaClO. An excess of NaBH 4 was used for the reduction step. Analysis of the reaction mixture indicated a maximum yield of 20% for vinblastine at pH 8.3, based on the initial amount of catharanthine concentration. Direct-injection electrospray ionization mass spectrometry in positive ion mode was used for the identification of vinblastine. The mass spectra of

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The cell and developmental biology of alkaloid biosynthesis

Cited by 323 publications

References 27 publications

Influence of plant resistance traits in selectiveness and species strength in a tropical plant‐herbivore network

Influence of plant resistance traits in selectiveness and species strength in a tropical plant‐herbivore network

Metabolite Measurements

A Simplified Procedure for Indole Alkaloid Extraction from Catharanthus roseus Combined with a Semi-synthetic Production Process for Vinblastine

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