The cells of origin of cat trigeminothalamic projections: Especially in the caudal medulla

Shigenaga, Yoshio; Nakatani, Ziro; Nishimori, Toshikazu; Suemune, Setsuko; Kuroda, R.; Matano, Shozo

doi:10.1016/0006-8993(83)90928-9

Cited by 117 publications

(39 citation statements)

References 79 publications

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“…The nucleus reticularis dorsalis, which is, in a sense, the caudal continuation of the parvocellularis [Newman, 1985a], relays trigeminal impulses to higher levels of the neuraxis [Shigenaga et al, 1983]. It is, therefore, reasonable that it receives inputs from face motor and face somatosensory cortices, as the present study has shown.…”

Section: Nuclear Variations In Corticoreticular Labeling Patternsmentioning

confidence: 49%

Nuclear Terminations of Corticoreticular Fiber Systems in Rats; pp. 253–264

Newman

Hilleary

Ginsberg³

1989

Brain Behav Evol

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Corticoreticular fiber systems were examined in adult albino and hooded rats using anterograde transport of wheat germ agglutinin-horseradish peroxidase (WGA-HRP) and anterograde degeneration. WGA-HRP injections were made stereotactically into the medial prefrontal cortex, the medial agranular cortex, the anterior cingulate cortex, the face motor cortex, the forelimb motor cortex, the trunk-hindlimb motor cortex, the face somatosensory cortex, the primary auditory cortex, the secondary visual cortex and the primary visual cortex. With the exception of the cingulate cortex (which is relatively inaccessible to lesioning methods) and the primary visual cortex, electrocautery lesions were made into these same cortical areas. The precise locations of cortical injection/lesion sites were corroborated on the basis of cortical cytoarchitectonic criteria, patterns of retrograde and anterograde thalamic labeling, and patterns of anterograde labeling in nonreticular brainstem nuclei such as the red nucleus, trigeminal nuclei and dorsal column nuclei.The heaviest corticoreticular projections arise from the medial agranular cortex. The medial prefrontal cortex also gives rise to consistently strong corticoreticular projections. The anterior cingulate cortex sends robust corticoreticular projections to the upper brainstem but relatively weak projections to the lower brainstem. With respect to the primary motor cortex, the face area gives rise to the densest corticoreticular projections, rivaling those emanating from the medial agranular cortex. The trunk-hindlimb area gives rise to substantial corticoreticular projections, but those originating from the forelimb area are modest and directed chiefly to midbrain and medullary levels. The face area of the somatosensory cortex gives rise to rather weak corticoreticular projections, while those arising from the primary auditory cortex are fewer still. Descending projections from the secondary visual cortex are sparse, with labeled terminals occurring in a few pontine and medullary reticular nuclei. Only one brainstem reticular nucleus (nucleus cuneiformis) was found to receive projections from the primary visual cortex, and this input was extremely sparse.Corticoreticular projections to the upper brainstem terminate predominately ipsilateral to the cortical injection site, whereas medullary corticoreticular projections distribute bilaterally. Corticoreticular fibers from the medial agranular, face motor and trunk-hindlimb motor cortex terminate heavily in somatomotor brainstem reticular nuclei such as the pontis oralis, the pontis caudalis and the gigantocellularis. Corticoreticular fibers from the prefrontal and cingulate cortices also target these nuclei but in addition send dense projections to autonomic brainstem reticular nuclei such as the A1-lateral reticular complex and the paragigantocellularis lateralis. The face area of the motor cortex projects to medullary reticular nuclei closely associated with the trigeminal system, such as the reticularis parvocellularis and the do...

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Section: Nuclear Variations In Corticoreticular Labeling Patternsmentioning

confidence: 49%

Nuclear Terminations of Corticoreticular Fiber Systems in Rats; pp. 253–264

Newman

Hilleary

Ginsberg³

1989

Brain Behav Evol

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“…These areas included the thalamic ventrobasal, intralaminar, and subthalamic ZI regions (Herkenham, 1979;Jones and Yang, 1985;Carstens et al, 1990;Newman and Ginsberg, 1994). Retrograde tracer injections in the Pf, Po, and VM in cats also labeled numerous cells in an area equivalent to the rat SRD (Shigenaga et al, 1983).…”

Section: Projections From the Srd To The Diencephalon: Anatomical Conmentioning

confidence: 93%

Organization of diencephalic projections from the medullary subnucleus reticularis dorsalis and the adjacent cuneate nucleus: A retrograde and anterograde tracer study in the rat

et al. 1998

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The distribution and organization of diencephalic projections from the subnucleus reticularis dorsalis (SRD) and the neighbouring cuneate nucleus (Cu) were studied in the rat by using microinjections of Phaseolus vulgaris leucoagglutinin in SRD and Cu and wheat germ agglutinin-apo horseradish peroxidase-gold in some selected thalamic areas. As previously reported, the efferent projections from the Cu were essentially contralateral and terminated mainly in the ventroposterolateral thalamic nucleus. Less dense terminals from the Cu were also observed in the posterior thalamic group, the ventral aspect of the zona incerta and the caudal and dorsal portion of the reuniens area. Retrograde tracer injections in the medial ventroposterolateral thalamic nucleus labeled numerous cells in the contralateral Cu, with a smaller number in the gracile nucleus. From the SRD, terminals were observed in the lateral aspect of the ventromedial thalamic nucleus, the lateral parafascicular area and, to a lesser extent, in the ventral aspect of the zona incerta and the core of the reuniens area. Retrograde tracer injections in the lateral part of the ventromedial thalamic nucleus labeled cells in the caudal medulla, many of which were located in the dorsal-most aspect of the SRD throughout its caudo-rostral extent. The existence of SRD-thalamic connections reinforces the idea that the caudal reticular formation is an important nociceptive relay to the thalamus. Our data shed new light on old hypotheses suggesting that, in addition to spino-thalamic pathways, spino-reticulo-thalamic pathways may play an important role in distributing pain signals to the forebrain.

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“…In the former species, the PrV but not the Vo contains many projection neurons with ascending axons projecting to the contralateral nucleus ventralis posteromedialis (VPM) of the thalamus (Shigenaga et al, 1983(Shigenaga et al, , 1986b. Therefore, it may be that the principal relay nucleus involved in the intraoral nociception is the PrV in the cat.…”

Section: Cgrp-ir Primary Afferent Projection To the Rostral Subdivisimentioning

confidence: 97%

Central projection of calcitonin gene-related peptide (CGRP)- and substance P (SP)-immunoreactive trigeminal primary neurons in the rat

et al. 1997

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Substance P (SP) is implicated in transmission of primary afferent nociceptive signals. In primary neurons, SP is colocalized with calcitonin gene-related peptide (CGRP), which is another neuropeptide marker for small to medium primary neurons. CGRP coreleased with SP augments the postsynaptic effect of SP and thereby modulates the nociceptive transmission. This study demonstrates the distribution of CGRP-like immunoreactivity (-ir) and SP-ir in the lower brainstem of normal rats and after trigeminal rhizotomy or tractotomy at the level of subnucleus interpolaris (Vi). By comparing the results obtained from normal and deafferented rats, we analyzed the central projection of trigeminal primary nociceptors. The CGRP-immunoreactive (-ir) trigeminal primaries projected to the entire rostrocaudal extent of the spinal trigeminal nucleus, the principal nucleus (PrV), the paratrigeminal nucleus (paraV), and the lateral subnucleus of solitary tract nucleus (STN) on the ipsilateral side. The trigeminal primaries projecting to the spinal trigeminal nucleus, paraV and STN also contained SP-ir. The ipsilateral trigeminal primaries were the exclusive source of CGRP-ir terminals in the PrV, the Vi and the dorsomedial nucleus within the subnucleus oralis (Vo). The medullary dorsal horn (MDH) and the lateral edge of Vo received convergent CGRP-ir projection from the ipsilateral trigeminal primaries and other neurons. The glossopharyngeal and vagal primaries are candidates for the source of CGRP-ir projection to the Vo and the MDH, while the dorsal root axons supply the MDH with CGRP-ir terminals. In addition, contralateral primary neurons crossing the midline appear to contain CGRP and to terminate in the MDH.

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The cells of origin of cat trigeminothalamic projections: Especially in the caudal medulla

Cited by 117 publications

References 79 publications

Nuclear Terminations of Corticoreticular Fiber Systems in Rats; pp. 253–264

Nuclear Terminations of Corticoreticular Fiber Systems in Rats; pp. 253–264

Organization of diencephalic projections from the medullary subnucleus reticularis dorsalis and the adjacent cuneate nucleus: A retrograde and anterograde tracer study in the rat

Central projection of calcitonin gene-related peptide (CGRP)- and substance P (SP)-immunoreactive trigeminal primary neurons in the rat

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