The cellular structure of bronchial carcinoids

Marks, Charles; Lamberty, Julia

doi:10.1136/pgmj.53.621.360

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…Case 14, which metastasised, was also a large tumour but the mitotic rate was low. Perineural invasion (cases 7 and 9) was not related to the development of metastases, as noted previously (Markel et al, 1964;Marks and Lamberty, 1977).…”

Section: Discussionsupporting

confidence: 77%

Pulmonary carcinoid tumours: a comparative regional study.

Cooney¹,

Sweeney²,

Luke³

1979

J Clin Pathol

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SUMMARY Twenty-two pulmonary carcinoid tumours (18 central, 4 peripheral) were seen in this department over an 11-year period. The majority of the tumours displayed a mixed pattern on microscopic examination, and cell-nest formation was a prominent feature in sixteen. The findings are at variance with the results of a similar series reported from Japan and suggest that there is regional variation in the tumour pattern of pulmonary carcinoids. Various aspects of the histopathology are discussed, and a causal relationship between ossification of bronchial cartilage in these tumours and locally produced calcitonin is postulated.There have been numerous reports of series of pulmonary carcinoid tumours over the past 17 years.

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Section: Discussionsupporting

confidence: 77%

Pulmonary carcinoid tumours: a comparative regional study.

Cooney¹,

Sweeney²,

Luke³

1979

J Clin Pathol

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“…Rectal NETs, even those with a small size and shallow depth of tumor invasion, can metastasize to the LLNs. Colorectal cancer develops from the mucosal epithelium; on the other hand, colorectal NETs develop from Kultschitzky cells that are located in the deep mucosa ( 23 ). The difference in origin may contribute to the slow metastasis to LLNs in the early stage.…”

Section: Discussionmentioning

confidence: 99%

Indications for lateral lymph node dissection in patients with rectal neuroendocrine tumors: A case report and review of the literature

et al. 2021

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The optimal surgical indications for small rectal neuroendocrine tumors (NETs) are controversial. Generally, treatment guidelines for rectal NETs >2 cm or with potential lymph node (LN) metastasis recommend formal oncologic low anterior resection (LAR) with total mesorectal excision (TME). However, rectal NETs have the potential to metastasize to the lateral lymph nodes (LLNs). To the best of our knowledge, there are no detailed reports in English on LLN metastasis from rectal NETs. A 47-year-old man diagnosed with a rectal NET underwent endoscopic submucosal dissection (ESD). The pathological diagnosis was NET G1. The tumor was 10 mm in diameter, and the tumor depth reached the submucosal layer. A period of 3 years after ESD, the patient was diagnosed with LN metastasis in the mesorectum and LLN metastasis on the left side from the NET. Robotic TME and bilateral LN dissection were performed. The pathological findings indicated that two of the 18 LNs in the mesorectum were metastatic, and all the LLNs on the left side were negative. In contrast, 1 of the 6 LLNs on the right side was metastatic. Early-stage rectal NETs can metastasize to the LLNs, and it is very difficult to detect LLN metastasis based on size alone. TME alone may be insufficient to treat rectal NETs, and additional LLN dissection may be an important treatment strategy. However, it is increasingly difficult to determine the surgical indications for optimally timed LLN dissection.

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Respiratory System

Cox¹

1981

Paediatric Pathology

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The cellular structure of bronchial carcinoids

Cited by 3 publications

References 6 publications

Pulmonary carcinoid tumours: a comparative regional study.

Pulmonary carcinoid tumours: a comparative regional study.

Indications for lateral lymph node dissection in patients with rectal neuroendocrine tumors: A case report and review of the literature

Respiratory System

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