2013
DOI: 10.1242/dev.092759
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The centriolar satellite protein Cep131 is important for genome stability

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Cited by 25 publications
(49 citation statements)
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“…1B). Furthermore, in a similar manner to that previously reported for Cep131 (Staples et al, 2012), increased cH2AX was only observed in Ccdc13-depleted cells in G1 following mitotic transit (Fig. 1B).…”
Section: Identification and Validation Of Ccdc13 As A Novel Regulatorsupporting
confidence: 89%
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“…1B). Furthermore, in a similar manner to that previously reported for Cep131 (Staples et al, 2012), increased cH2AX was only observed in Ccdc13-depleted cells in G1 following mitotic transit (Fig. 1B).…”
Section: Identification and Validation Of Ccdc13 As A Novel Regulatorsupporting
confidence: 89%
“…We have recently carried out a genome-wide siRNA screen to identify novel regulators of genome stability (Staples et al, 2012) by using phosphorylation of the histone variant H2AX on Ser139 (termed cH2AX) as a marker of increased DNA damage (Bonner et al, 2008). As part of this screen, we identified Ccdc13, which yielded a high Z-score of 2.2.…”
Section: Identification and Validation Of Ccdc13 As A Novel Regulatormentioning
confidence: 99%
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“…The second variant introduced a change at the conserved position p.(A876V) in AZI1 (Azacytidine-induced 1), which is a protein involved in the regulation of genome stability. 18 This variant is potentially deleterious to protein function (Mutation taster prediction: disease causing); however, currently there are no published data that would directly implicate AZI1 gene in tumorigenesis.…”
Section: Nf1 Cutaneous Neurofibroma Somatic Mutations D Emmerich Et Almentioning
confidence: 99%